O43684: Mitotic checkpoint protein BUB3

General Information

Protein names	- Mitotic checkpoint protein BUB3
Gene names	BUB3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43684

12 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTGSNEFKLN QPPEDGISSV KFSPNTSQFL LVSSWDTSVR LYDVPANSMR LKYQHTGAVL
        70         80         90        100        110        120
DCAFYDPTHA WSGGLDHQLK MHDLNTDQEN LVGTHDAPIR CVEYCPEVNV MVTGSWDQTV
       130        140        150        160        170        180
KLWDPRTPCN AGTFSQPEKV YTLSVSGDRL IVGTAGRRVL VWDLRNMGYV QQRRESSLKY
       190        200        210        220        230        240
QTRCIRAFPN KQGYVLSSIE GRVAVEYLDP SPEVQKKKYA FKCHRLKENN IEQIYPVNAI
       250        260        270        280        290        300
SFHNIHNTFA TGGSDGFVNI WDPFNKKRLC QFHRYPTSIA SLAFSNDGTT LAIASSYMYE
       310        320
MDDTEHPEDG IFIRQVTDAE TKPKSPCT

Isoforms

- Isoform 2 of Mitotic checkpoint protein BUB3

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43684-1-unknown	MTGSNE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43684-1-unknown	MTGSNE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68765
O43684-4-	SNEFKL...	4		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43684-4-unknown	SNEFKL...	4	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173083
O43684-71-unknown	WSGGLD...	71	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3277
O43684-71-unknown	WSGGLD...	71	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140748
O43684-81-unknown	MHDLNT...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166727
O43684-81-	MHDLNT...	81		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43684-81-	MHDLNT...	81		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43684-81-	MHDLNT...	81		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43684-81-	MHDLNT...	81		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43684-85-	NTDQEN...	85		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43684-85-unknown	NTDQEN...	85	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173081
O43684-296-	SYMYEM...	296		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43684-296-	SYMYEM...	296		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43684-296-	SYMYEM...	296		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43684-296-	SYMYEM...	296		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O43684-296-	SYMYEM...	296		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43684-296-	SYMYEM...	296		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43684-296-unknown	SYMYEM...	296	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166725
O43684-298-	MYEMDD...	298		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43684-298-	MYEMDD...	298		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43684-298-	MYEMDD...	298		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O43684-298-	MYEMDD...	298		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43684-298-unknown	MYEMDD...	298	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166723

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DPTHAW	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3277
...DPTHAW	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123883
...KSPCT	328	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	70	THAW.\|.WSGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)