O60885: Bromodomain-containing protein 4

General Information

Protein names	- Bromodomain-containing protein 4 - Protein HUNK1
Gene names	BRD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60885

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT
        70         80         90        100        110        120
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW
       130        140        150        160        170        180
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG
       190        200        210        220        230        240
RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT
       250        260        270        280        290        300
VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI
       310        320        330        340        350        360
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI
       370        380        390        400        410        420
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA
       430        440        450        460        470        480
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV
       490        500        510        520        530        540
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE
       550        560        570        580        590        600
KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE
       610        620        630        640        650        660
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK
       670        680        690        700        710        720
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESSSESS SSDSEDSETE
       730        740        750        760        770        780
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPP QQQQQPPPPP
       790        800        810        820        830        840
PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP
       850        860        870        880        890        900
QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL
       910        920        930        940        950        960
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP
       970        980        990       1000       1010       1020
PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP
      1030       1040       1050       1060       1070       1080
HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT
      1090       1100       1110       1120       1130       1140
HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI
      1150       1160       1170       1180       1190       1200
KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG
      1210       1220       1230       1240       1250       1260
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM
      1270       1280       1290       1300       1310       1320
RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ AAAVAAAATP QAQSSQPQSM
      1330       1340       1350       1360
LDQQRELARK REQERRRREA MAATIDMNFQ SDLLSIFEEN LF

Isoforms

- Isoform C of Bromodomain-containing protein 4 - Isoform B of Bromodomain-containing protein 4

Sequence View

        10         20         30         40         50         60
MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT
        70         80         90        100        110        120
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW
       130        140        150        160        170        180
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG
       190        200        210        220        230        240
RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT
       250        260        270        280        290        300
VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI
       310        320        330        340        350        360
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI
       370        380        390        400        410        420
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA
       430        440        450        460        470        480
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV
       490        500        510        520        530        540
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE
       550        560        570        580        590        600
KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE
       610        620        630        640        650        660
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK
       670        680        690        700        710        720
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESSSESS SSDSEDSETE
       730        740        750        760        770        780
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPP QQQQQPPPPP
       790        800        810        820        830        840
PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP
       850        860        870        880        890        900
QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL
       910        920        930        940        950        960
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP
       970        980        990       1000       1010       1020
PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP
      1030       1040       1050       1060       1070       1080
HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT
      1090       1100       1110       1120       1130       1140
HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI
      1150       1160       1170       1180       1190       1200
KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG
      1210       1220       1230       1240       1250       1260
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM
      1270       1280       1290       1300       1310       1320
RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ AAAVAAAATP QAQSSQPQSM
      1330       1340       1350       1360
LDQQRELARK REQERRRREA MAATIDMNFQ SDLLSIFEEN LF         10         20         30         40         50         60
MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT
        70         80         90        100        110        120
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW
       130        140        150        160        170        180
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG
       190        200        210        220        230        240
RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT
       250        260        270        280        290        300
VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI
       310        320        330        340        350        360
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI
       370        380        390        400        410        420
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA
       430        440        450        460        470        480
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV
       490        500        510        520        530        540
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE
       550        560        570        580        590        600
KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE
       610        620        630        640        650        660
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK
       670        680        690        700        710        720
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESSSESS SSDSEDSETE
       730        740        750        760        770        780
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPP QQQQQPPPPP
       790        800        810        820        830        840
PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP
       850        860        870        880        890        900
QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL
       910        920        930        940        950        960
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP
       970        980        990       1000       1010       1020
PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP
      1030       1040       1050       1060       1070       1080
HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT
      1090       1100       1110       1120       1130       1140
HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI
      1150       1160       1170       1180       1190       1200
KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG
      1210       1220       1230       1240       1250       1260
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM
      1270       1280       1290       1300       1310       1320
RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ AAAVAAAATP QAQSSQPQSM
      1330       1340       1350       1360
LDQQRELARK REQERRRREA MAATIDMNFQ SDLLSIFEEN LF

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60885-1-unknown	MSAESG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60885-1-unknown	MSAESG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68608
O60885-1-unknown	MSAESG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68607
O60885-26-unknown	MSTTQA...	26	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
O60885-26-unknown	MSTTQA...	26	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195407
O60885-26-unknown	MSTTQA...	26	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195408
O60885-338-unknown	SQQHPA...	338		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O60885-338-unknown	SQQHPA...	338	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161321
O60885-338-unknown	SQQHPA...	338	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161322
O60885-338-	SQQHPA...	338		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O60885-656-unknown	FETLKP...	656	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10894
O60885-656-unknown	FETLKP...	656	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155393
O60885-656-unknown	FETLKP...	656	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155394
O60885-865-	ALPQQP...	865		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60885-1100-	SVVQPQ...	1100		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O60885-1100-	SVVQPQ...	1100		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60885-1100-	SVVQPQ...	1100		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60885-1100-	SVVQPQ...	1100		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EIEIDF	655	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10894
...EIEIDF	655	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138828
...EIEIDF	655	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138829
...EENLF	1362	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

TopFIND

O60885: Bromodomain-containing protein 4

General Information

7

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates