O60885: Bromodomain-containing protein 4
Protein names | - Bromodomain-containing protein 4 - Protein HUNK1 |
---|---|
Gene names | BRD4 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O60885 |
7
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT
70 80 90 100 110 120
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW
130 140 150 160 170 180
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG
190 200 210 220 230 240
RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT
250 260 270 280 290 300
VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI
310 320 330 340 350 360
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI
370 380 390 400 410 420
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA
430 440 450 460 470 480
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV
490 500 510 520 530 540
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE
550 560 570 580 590 600
KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE
610 620 630 640 650 660
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK
670 680 690 700 710 720
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESSSESS SSDSEDSETE
730 740 750 760 770 780
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPP QQQQQPPPPP
790 800 810 820 830 840
PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP
850 860 870 880 890 900
QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL
910 920 930 940 950 960
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP
970 980 990 1000 1010 1020
PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP
1030 1040 1050 1060 1070 1080
HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT
1090 1100 1110 1120 1130 1140
HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI
1150 1160 1170 1180 1190 1200
KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG
1210 1220 1230 1240 1250 1260
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM
1270 1280 1290 1300 1310 1320
RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ AAAVAAAATP QAQSSQPQSM
1330 1340 1350 1360
LDQQRELARK REQERRRREA MAATIDMNFQ SDLLSIFEEN LF
Isoforms
- Isoform C of Bromodomain-containing protein 4 - Isoform B of Bromodomain-containing protein 4Sequence View
10 20 30 40 50 60
MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT
70 80 90 100 110 120
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW
130 140 150 160 170 180
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG
190 200 210 220 230 240
RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT
250 260 270 280 290 300
VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI
310 320 330 340 350 360
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI
370 380 390 400 410 420
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA
430 440 450 460 470 480
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV
490 500 510 520 530 540
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE
550 560 570 580 590 600
KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE
610 620 630 640 650 660
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK
670 680 690 700 710 720
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESSSESS SSDSEDSETE
730 740 750 760 770 780
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPP QQQQQPPPPP
790 800 810 820 830 840
PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP
850 860 870 880 890 900
QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL
910 920 930 940 950 960
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP
970 980 990 1000 1010 1020
PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP
1030 1040 1050 1060 1070 1080
HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT
1090 1100 1110 1120 1130 1140
HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI
1150 1160 1170 1180 1190 1200
KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG
1210 1220 1230 1240 1250 1260
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM
1270 1280 1290 1300 1310 1320
RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ AAAVAAAATP QAQSSQPQSM
1330 1340 1350 1360
LDQQRELARK REQERRRREA MAATIDMNFQ SDLLSIFEEN LF
10 20 30 40 50 60
MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT
70 80 90 100 110 120
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW
130 140 150 160 170 180
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG
190 200 210 220 230 240
RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT
250 260 270 280 290 300
VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI
310 320 330 340 350 360
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI
370 380 390 400 410 420
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA
430 440 450 460 470 480
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV
490 500 510 520 530 540
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE
550 560 570 580 590 600
KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE
610 620 630 640 650 660
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK
670 680 690 700 710 720
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESSSESS SSDSEDSETE
730 740 750 760 770 780
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPP QQQQQPPPPP
790 800 810 820 830 840
PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP
850 860 870 880 890 900
QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL
910 920 930 940 950 960
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP
970 980 990 1000 1010 1020
PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP
1030 1040 1050 1060 1070 1080
HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT
1090 1100 1110 1120 1130 1140
HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI
1150 1160 1170 1180 1190 1200
KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG
1210 1220 1230 1240 1250 1260
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM
1270 1280 1290 1300 1310 1320
RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ AAAVAAAATP QAQSSQPQSM
1330 1340 1350 1360
LDQQRELARK REQERRRREA MAATIDMNFQ SDLLSIFEEN LF
Protein Neighborhood
Domains & Features
7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O60885-1-unknown | MSAESG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O60885-1-unknown | MSAESG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt68608 | |||
O60885-1-unknown | MSAESG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt68607 | |||
O60885-26-unknown | MSTTQA... | 26 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
O60885-26-unknown | MSTTQA... | 26 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt195407 | |||
O60885-26-unknown | MSTTQA... | 26 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt195408 | |||
O60885-338-unknown | SQQHPA... | 338 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O60885-338-unknown | SQQHPA... | 338 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161321 | |||
O60885-338-unknown | SQQHPA... | 338 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161322 | |||
O60885-338- | SQQHPA... | 338 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
O60885-656-unknown | FETLKP... | 656 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10894 | |||
O60885-656-unknown | FETLKP... | 656 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155393 | |||
O60885-656-unknown | FETLKP... | 656 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155394 | |||
O60885-865- | ALPQQP... | 865 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O60885-1100- | SVVQPQ... | 1100 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
O60885-1100- | SVVQPQ... | 1100 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O60885-1100- | SVVQPQ... | 1100 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O60885-1100- | SVVQPQ... | 1100 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...EIEIDF | 655 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10894 | |||
...EIEIDF | 655 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138828 | |||
...EIEIDF | 655 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138829 | |||
...EENLF | 1362 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 655 | EIDF.|.FETL | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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