O75116: Rho-associated protein kinase 2

General Information

Protein names	- Rho-associated protein kinase 2 - 2.7.11.1 - Rho kinase 2 - Rho-associated, coiled-coil-containing protein kinase 2 - Rho-associated, coiled-coil-containing protein kinase II - ROCK-II - p164 ROCK-2
Gene names	ROCK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75116

7 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRPPPTGKM PGAPETAPGD GAGASRQRKL EALIRDPRSP INVESLLDGL NSLVLDLDFP
        70         80         90        100        110        120
ALRKNKNIDN FLNRYEKIVK KIRGLQMKAE DYDVVKVIGR GAFGEVQLVR HKASQKVYAM
       130        140        150        160        170        180
KLLSKFEMIK RSDSAFFWEE RDIMAFANSP WVVQLFYAFQ DDRYLYMVME YMPGGDLVNL
       190        200        210        220        230        240
MSNYDVPEKW AKFYTAEVVL ALDAIHSMGL IHRDVKPDNM LLDKHGHLKL ADFGTCMKMD
       250        260        270        280        290        300
ETGMVHCDTA VGTPDYISPE VLKSQGGDGF YGRECDWWSV GVFLYEMLVG DTPFYADSLV
       310        320        330        340        350        360
GTYSKIMDHK NSLCFPEDAE ISKHAKNLIC AFLTDREVRL GRNGVEEIRQ HPFFKNDQWH
       370        380        390        400        410        420
WDNIRETAAP VVPELSSDID SSNFDDIEDD KGDVETFPIP KAFVGNQLPF IGFTYYRENL
       430        440        450        460        470        480
LLSDSPSCRE TDSIQSRKNE ESQEIQKKLY TLEEHLSNEM QAKEELEQKC KSVNTRLEKT
       490        500        510        520        530        540
AKELEEEITL RKSVESALRQ LEREKALLQH KNAEYQRKAD HEADKKRNLE NDVNSLKDQL
       550        560        570        580        590        600
EDLKKRNQNS QISTEKVNQL QRQLDETNAL LRTESDTAAR LRKTQAESSK QIQQLESNNR
       610        620        630        640        650        660
DLQDKNCLLE TAKLKLEKEF INLQSALESE RRDRTHGSEI INDLQGRICG LEEDLKNGKI
       670        680        690        700        710        720
LLAKVELEKR QLQERFTDLE KEKSNMEIDM TYQLKVIQQS LEQEEAEHKA TKARLADKNK
       730        740        750        760        770        780
IYESIEEAKS EAMKEMEKKL LEERTLKQKV ENLLLEAEKR CSLLDCDLKQ SQQKINELLK
       790        800        810        820        830        840
QKDVLNEDVR NLTLKIEQET QKRCLTQNDL KMQTQQVNTL KMSEKQLKQE NNHLMEMKMN
       850        860        870        880        890        900
LEKQNAELRK ERQDADGQMK ELQDQLEAEQ YFSTLYKTQV RELKEECEEK TKLGKELQQK
       910        920        930        940        950        960
KQELQDERDS LAAQLEITLT KADSEQLARS IAEEQYSDLE KEKIMKELEI KEMMARHKQE
       970        980        990       1000       1010       1020
LTEKDATIAS LEETNRTLTS DVANLANEKE ELNNKLKDVQ EQLSRLKDEE ISAAAIKAQF
      1030       1040       1050       1060       1070       1080
EKQLLTERTL KTQAVNKLAE IMNRKEPVKR GNDTDVRRKE KENRKLHMEL KSEREKLTQQ
      1090       1100       1110       1120       1130       1140
MIKYQKELNE MQAQIAEESQ IRIELQMTLD SKDSDIEQLR SQLQALHIGL DSSSIGSGPG
      1150       1160       1170       1180       1190       1200
DAEADDGFPE SRLEGWLSLP VRNNTKKFGW VKKYVIVSSK KILFYDSEQD KEQSNPYMVL
      1210       1220       1230       1240       1250       1260
DIDKLFHVRP VTQTDVYRAD AKEIPRIFQI LYANEGESKK EQEFPVEPVG EKSNYICHKG
      1270       1280       1290       1300       1310       1320
HEFIPTLYHF PTNCEACMKP LWHMFKPPPA LECRRCHIKC HKDHMDKKEE IIAPCKVYYD
      1330       1340       1350       1360       1370       1380
ISTAKNLLLL ANSTEEQQKW VSRLVKKIPK KPPAPDPFAR SSPRTSMKIQ QNQSIRRPSR

QLAPNKPS

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75116-1-unknown	MSRPPP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75116-2-acetylation	SRPPPT...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O75116-87-unknown	MKAEDY...	87		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000395957
O75116-244-unknown	MVHCDT...	244		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000385509
O75116-381-	SSNFDD...	381			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75116-1132-unknown	SSSIGS...	1132		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10901
O75116-1132-unknown	SSSIGS...	1132		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75116-1132-	SSSIGS...	1132			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VPELSS	376	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395957
...HIGLDS	1131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10901
...PNKPS	1388	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	1131	GLDS.\|.SSSI	inferred from experiment	unknown	MEROPS	Breard J	Sebbagh M et al.:Direct cleavage of ROCK II by g... (S01.010)	15699075,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)