O75376: Nuclear receptor corepressor 1

General Information

Protein names	- Nuclear receptor corepressor 1 - N-CoR - N-CoR1
Gene names	NCOR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75376

14 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nuclear receptor corepressor 1 - Isoform 3 of Nuclear receptor corepressor 1

Sequence View

        10         20         30         40         50         60
MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV SQASQLLQQQ
        70         80         90        100        110        120
QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD HDSLESKRPR LEQVSDSHFQ
       130        140        150        160        170        180
RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE
       190        200        210        220        230        240
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY
       250        260        270        280        290        300
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR
       310        320        330        340        350        360
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ
       370        380        390        400        410        420
RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM
       430        440        450        460        470        480
NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL
       490        500        510        520        530        540
TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE
       550        560        570        580        590        600
KEDSKENTKE KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT NEAAAASAAA
       610        620        630        640        650        660
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA
       670        680        690        700        710        720
QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE SVASTVSAQE DEDIEASNEE
       730        740        750        760        770        780
ENPEDSEVEA VKPSEDSPEN ATSRGNTEPA VELEPTTETA PSTSPSLAVP STKPAEDESV
       790        800        810        820        830        840
ETQVNDSISA ETAEQMDVDQ QEHSAEEGSV CDPPPATKAD SVDVEVRVPE NHASKVEGDN
       850        860        870        880        890        900
TKERDLDRAS EKVEPRDEDL VVAQQINAQR PEPQSDNDSS ATCSADEDVD GEPERQRMFP
       910        920        930        940        950        960
MDSKPSLLNP TGSILVSSPL KPNPLDLPQL QHRAAVIPPM VSCTPCNIPI GTPVSGYALY
       970        980        990       1000       1010       1020
QRHIKAMHES ALLEEQRQRQ EQIDLECRSS TSPCGTSKSP NREWEVLQPA PHQVITNLPE
      1030       1040       1050       1060       1070       1080
GVRLPTTRPT RPPPPLIPSS KTTVASEKPS FIMGGSISQG TPGTYLTSHN QASYTQETPK
      1090       1100       1110       1120       1130       1140
PSVGSISLGL PRQQESAKSA TLPYIKQEEF SPRSQNSQPE GLLVRAQHEG VVRGTAGAIQ
      1150       1160       1170       1180       1190       1200
EGSITRGTPT SKISVESIPS LRGSITQGTP ALPQTGIPTE ALVKGSISRM PIEDSSPEKG
      1210       1220       1230       1240       1250       1260
REEAASKGHV IYEGKSGHIL SYDNIKNARE GTRSPRTAHE ISLKRSYESV EGNIKQGMSM
      1270       1280       1290       1300       1310       1320
RESPVSAPLE GLICRALPRG SPHSDLKERT VLSGSIMQGT PRATTESFED GLKYPKQIKR
      1330       1340       1350       1360       1370       1380
ESPPIRAFEG AITKGKPYDG ITTIKEMGRS IHEIPRQDIL TQESRKTPEV VQSTRPIIEG
      1390       1400       1410       1420       1430       1440
SISQGTPIKF DNNSGQSAIK HNVKSLITGP SKLSRGMPPL EIVPENIKVV ERGKYEDVKA
      1450       1460       1470       1480       1490       1500
GETVRSRHTS VVSSGPSVLR STLHEAPKAQ LSPGIYDDTS ARRTPVSYQN TMSRGSPMMN
      1510       1520       1530       1540       1550       1560
RTSDVTISSN KSTNHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH HRGSTAGEVY
      1570       1580       1590       1600       1610       1620
RSHLPTHLDP AMPFHRALDP AAAAYLFQRQ LSPTPGYPSQ YQLYAMENTR QTILNDYITS
      1630       1640       1650       1660       1670       1680
QQMQVNLRPD VARGLSPREQ PLGLPYPATR GIIDLTNMPP TILVPHPGGT STPPMDRITY
      1690       1700       1710       1720       1730       1740
IPGTQITFPP RPYNSASMSP GHPTHLAAAA SAERERERER EKERERERIA AASSDLYLRP
      1750       1760       1770       1780       1790       1800
GSEQPGRPGS HGYVRSPSPS VRTQETMLQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPA
      1810       1820       1830       1840       1850       1860
GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE ENLRSRSAAV
      1870       1880       1890       1900       1910       1920
SEQQQLEQKT LEVEKRSVQC LYTSSAFPSG KPQPHSSVVY SEAGKDKGPP PKSRYEEELR
      1930       1940       1950       1960       1970       1980
TRGKTTITAA NFIDVIITRQ IASDKDARER GSQSSDSSSS LSSHRYETPS DAIEVISPAS
      1990       2000       2010       2020       2030       2040
SPAPPQEKLQ TYQPEVVKAN QAENDPTRQY EGPLHHYRPQ QESPSPQQQL PPSSQAEGMG
      2050       2060       2070       2080       2090       2100
QVPRTHRLIT LADHICQIIT QDFARNQVSS QTPQQPPTST FQNSPSALVS TPVRTKTSNR
      2110       2120       2130       2140       2150       2160
YSPESQAQSV HHQRPGSRVS PENLVDKSRG SRPGKSPERS HVSSEPYEPI SPPQVPVVHE
      2170       2180       2190       2200       2210       2220
KQDSLLLLSQ RGAEPAEQRN DARSPGSISY LPSFFTKLEN TSPMVKSKKQ EIFRKLNSSG
      2230       2240       2250       2260       2270       2280
GGDSDMAAAQ PGTEIFNLPA VTTSGSVSSR GHSFADPASN LGLEDIIRKA LMGSFDDKVE
      2290       2300       2310       2320       2330       2340
DHGVVMSQPM GVVPGTANTS VVTSGETRRE EGDPSPHSGG VCKPKLISKS NSRKSKSPIP
      2350       2360       2370       2380       2390       2400
GQGYLGTERP SSVSSVHSEG DYHRQTPGWA WEDRPSSTGS TQFPYNPLTM RMLSSTPPTP
      2410       2420       2430       2440
IACAPSAVNQ AAPHQQNRIW EREPAPLLSA QYETLSDSDD         10         20         30         40         50         60
MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV SQASQLLQQQ
        70         80         90        100        110        120
QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD HDSLESKRPR LEQVSDSHFQ
       130        140        150        160        170        180
RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE
       190        200        210        220        230        240
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY
       250        260        270        280        290        300
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR
       310        320        330        340        350        360
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ
       370        380        390        400        410        420
RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM
       430        440        450        460        470        480
NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL
       490        500        510        520        530        540
TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE
       550        560        570        580        590        600
KEDSKENTKE KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT NEAAAASAAA
       610        620        630        640        650        660
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA
       670        680        690        700        710        720
QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE SVASTVSAQE DEDIEASNEE
       730        740        750        760        770        780
ENPEDSEVEA VKPSEDSPEN ATSRGNTEPA VELEPTTETA PSTSPSLAVP STKPAEDESV
       790        800        810        820        830        840
ETQVNDSISA ETAEQMDVDQ QEHSAEEGSV CDPPPATKAD SVDVEVRVPE NHASKVEGDN
       850        860        870        880        890        900
TKERDLDRAS EKVEPRDEDL VVAQQINAQR PEPQSDNDSS ATCSADEDVD GEPERQRMFP
       910        920        930        940        950        960
MDSKPSLLNP TGSILVSSPL KPNPLDLPQL QHRAAVIPPM VSCTPCNIPI GTPVSGYALY
       970        980        990       1000       1010       1020
QRHIKAMHES ALLEEQRQRQ EQIDLECRSS TSPCGTSKSP NREWEVLQPA PHQVITNLPE
      1030       1040       1050       1060       1070       1080
GVRLPTTRPT RPPPPLIPSS KTTVASEKPS FIMGGSISQG TPGTYLTSHN QASYTQETPK
      1090       1100       1110       1120       1130       1140
PSVGSISLGL PRQQESAKSA TLPYIKQEEF SPRSQNSQPE GLLVRAQHEG VVRGTAGAIQ
      1150       1160       1170       1180       1190       1200
EGSITRGTPT SKISVESIPS LRGSITQGTP ALPQTGIPTE ALVKGSISRM PIEDSSPEKG
      1210       1220       1230       1240       1250       1260
REEAASKGHV IYEGKSGHIL SYDNIKNARE GTRSPRTAHE ISLKRSYESV EGNIKQGMSM
      1270       1280       1290       1300       1310       1320
RESPVSAPLE GLICRALPRG SPHSDLKERT VLSGSIMQGT PRATTESFED GLKYPKQIKR
      1330       1340       1350       1360       1370       1380
ESPPIRAFEG AITKGKPYDG ITTIKEMGRS IHEIPRQDIL TQESRKTPEV VQSTRPIIEG
      1390       1400       1410       1420       1430       1440
SISQGTPIKF DNNSGQSAIK HNVKSLITGP SKLSRGMPPL EIVPENIKVV ERGKYEDVKA
      1450       1460       1470       1480       1490       1500
GETVRSRHTS VVSSGPSVLR STLHEAPKAQ LSPGIYDDTS ARRTPVSYQN TMSRGSPMMN
      1510       1520       1530       1540       1550       1560
RTSDVTISSN KSTNHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH HRGSTAGEVY
      1570       1580       1590       1600       1610       1620
RSHLPTHLDP AMPFHRALDP AAAAYLFQRQ LSPTPGYPSQ YQLYAMENTR QTILNDYITS
      1630       1640       1650       1660       1670       1680
QQMQVNLRPD VARGLSPREQ PLGLPYPATR GIIDLTNMPP TILVPHPGGT STPPMDRITY
      1690       1700       1710       1720       1730       1740
IPGTQITFPP RPYNSASMSP GHPTHLAAAA SAERERERER EKERERERIA AASSDLYLRP
      1750       1760       1770       1780       1790       1800
GSEQPGRPGS HGYVRSPSPS VRTQETMLQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPA
      1810       1820       1830       1840       1850       1860
GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE ENLRSRSAAV
      1870       1880       1890       1900       1910       1920
SEQQQLEQKT LEVEKRSVQC LYTSSAFPSG KPQPHSSVVY SEAGKDKGPP PKSRYEEELR
      1930       1940       1950       1960       1970       1980
TRGKTTITAA NFIDVIITRQ IASDKDARER GSQSSDSSSS LSSHRYETPS DAIEVISPAS
      1990       2000       2010       2020       2030       2040
SPAPPQEKLQ TYQPEVVKAN QAENDPTRQY EGPLHHYRPQ QESPSPQQQL PPSSQAEGMG
      2050       2060       2070       2080       2090       2100
QVPRTHRLIT LADHICQIIT QDFARNQVSS QTPQQPPTST FQNSPSALVS TPVRTKTSNR
      2110       2120       2130       2140       2150       2160
YSPESQAQSV HHQRPGSRVS PENLVDKSRG SRPGKSPERS HVSSEPYEPI SPPQVPVVHE
      2170       2180       2190       2200       2210       2220
KQDSLLLLSQ RGAEPAEQRN DARSPGSISY LPSFFTKLEN TSPMVKSKKQ EIFRKLNSSG
      2230       2240       2250       2260       2270       2280
GGDSDMAAAQ PGTEIFNLPA VTTSGSVSSR GHSFADPASN LGLEDIIRKA LMGSFDDKVE
      2290       2300       2310       2320       2330       2340
DHGVVMSQPM GVVPGTANTS VVTSGETRRE EGDPSPHSGG VCKPKLISKS NSRKSKSPIP
      2350       2360       2370       2380       2390       2400
GQGYLGTERP SSVSSVHSEG DYHRQTPGWA WEDRPSSTGS TQFPYNPLTM RMLSSTPPTP
      2410       2420       2430       2440
IACAPSAVNQ AAPHQQNRIW EREPAPLLSA QYETLSDSDD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

14 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75376-1-unknown	MSSSGY...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75376-1-unknown	MSSSGY...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82432
O75376-1-unknown	MSSSGY...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82433
O75376-124-	AAVLPL...	124		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75376-124-	AAVLPL...	124		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O75376-124-	AAVLPL...	124		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75376-124-	AAVLPL...	124		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75376-124-unknown	AAVLPL...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167232
O75376-386-unknown	GLSEQE...	386		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75376-386-unknown	GLSEQE...	386	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161855
O75376-386-unknown	GLSEQE...	386	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161856
O75376-386-	GLSEQE...	386		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75376-386-	GLSEQE...	386		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75376-386-	GLSEQE...	386		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75376-386-	GLSEQE...	386		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75376-386-	GLSEQE...	386		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75376-556-	GTAEET...	556		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75376-556-	GTAEET...	556		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75376-556-	GTAEET...	556		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75376-556-unknown	GTAEET...	556		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75376-556-unknown	GTAEET...	556	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161858
O75376-556-unknown	GTAEET...	556	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161859
O75376-1134-	GTAGAI...	1134		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75376-1134-	GTAGAI...	1134		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75376-1134-unknown	GTAGAI...	1134	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167234
O75376-1168-	GTPALP...	1168		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75376-1168-unknown	GTPALP...	1168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167236
O75376-1827-	AAASAP...	1827		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75376-1827-	AAASAP...	1827		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75376-1827-	AAASAP...	1827		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75376-1827-	AAASAP...	1827		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75376-1827-	AAASAP...	1827		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75376-1827-unknown	AAASAP...	1827		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75376-2123-unknown	NLVDKS...	2123	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10944
O75376-2123-unknown	NLVDKS...	2123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158798

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RVSPEN	2122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10944
...RVSPEN	2122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt142302
...SDSDD	2440	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SDSDD	2440	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78050

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	2122	SPEN.\|.NLVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)