O75683: Surfeit locus protein 6

General Information

Protein names	- Surfeit locus protein 6
Gene names	SURF6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75683

8 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK TQKKFRKREE
        70         80         90        100        110        120
KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP ADGLATEPES VFALDVLRQR
       130        140        150        160        170        180
LHEKIQEARG QGSAKELSPA ALEKRRRRKQ ERDRKKRKRK ELRAKEKARK AEEATEAQEV
       190        200        210        220        230        240
VEATPEGACT EPREPPGLIF NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL
       250        260        270        280        290        300
ERLQARQSRL DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR
       310        320        330        340        350        360
AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI LPQDLERAGL

V

Isoforms

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75683-1-unknown	MASLLA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75683-2-acetylation	ASLLAK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O75683-2-acetylation	ASLLAK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O75683-69-unknown	SLGEKS...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9917
O75683-105-unknown	ATEPES...	105		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13847
O75683-109-unknown	ESVFAL...	109			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75683-110-unknown	SVFALD...	110		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10961
O75683-189-unknown	CTEPRE...	189		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13848
O75683-201-unknown	NKVEVS...	201		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13849

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EHKAKS	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9917
...PADGLA	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13847
...ATEPES	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10961
...TPEGAC	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13848
...PGLIFN	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13849
...RAGLV	361	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	68	KAKS.\|.SLGE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	104	DGLA.\|.ATEP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	109	EPES.\|.SVFA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	188	EGAC.\|.CTEP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	200	LIFN.\|.NKVE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)