O95155: Ubiquitin conjugation factor E4 B {ECO:0000305}

General Information

Protein names	- Ubiquitin conjugation factor E4 B {ECO:0000305} - 2.3.2.27 {ECO:0000250\|UniProtKB:Q9ES00} - Homozygously deleted in neuroblastoma 1 {ECO:0000312\|EMBL:BAB40446.1} - RING-type E3 ubiquitin transferase E4 B - Ubiquitin fusion degradation protein 2 {ECO:0000312\|EMBL:AAD02233.1}
Gene names	UBE4B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95155

10 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ubiquitin conjugation factor E4 B - Isoform 3 of Ubiquitin conjugation factor E4 B - Isoform 4 of Ubiquitin conjugation factor E4 B

Sequence View

        10         20         30         40         50         60
MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM
        70         80         90        100        110        120
TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV
       130        140        150        160        170        180
DVDSGIENME VDENDRREKR SLSDKEPSSG PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL
       190        200        210        220        230        240
SSLSAQFKQN PKEVFSDFKD LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIAAAARSPD
       250        260        270        280        290        300
RNLLLNTGSN PGTSPMFCSV ASFGASSLSS LYESSPAPTP SFWSSVPVMG PSLASPSRAA
       310        320        330        340        350        360
SQLAVPSTPL SPHSAASGTA AGSQPSSPRY RPYTVTHPWA SSGVSILSSS PSPPALASSP
       370        380        390        400        410        420
QAVPASSSRQ RPSSTGPPLP PASPSATSRR PSSLRISPSL GASGGASNWD SYSDHFTIET
       430        440        450        460        470        480
CKETDMLNYL IECFDRVGIE EKKAPKMCSQ PAVSQLLSNI RSQCISHTAL VLQGSLTQPR
       490        500        510        520        530        540
SLQQPSFLVP YMLCRNLPYG FIQELVRTTH QDEEVFKQIF IPILQGLALA AKECSLDSDY
       550        560        570        580        590        600
FKYPLMALGE LCETKFGKTH PVCNLVASLR LWLPKSLSPG CGRELQRLSY LGAFFSFSVF
       610        620        630        640        650        660
AEDDVKVVEK YFSGPAITLE NTRVVSQSLQ HYLELGRQEL FKILHSILLN GETREAALSY
       670        680        690        700        710        720
MAAVVNANMK KAQMQTDDRL VSTDGFMLNF LWVLQQLSTK IKLETVDPTY IFHPRCRITL
       730        740        750        760        770        780
PNDETRVNAT MEDVNDWLTE LYGDQPPFSE PKFPTECFFL TLHAHHLSIL PSCRRYIRRL
       790        800        810        820        830        840
RAIRELNRTV EDLKNNESQW KDSPLATRHR EMLKRCKTQL KKLVRCKACA DAGLLDESFL
       850        860        870        880        890        900
RRCLNFYGLL IQLLLRILDP AYPDITLPLN SDVPKVFAAL PEFYVEDVAE FLFFIVQYSP
       910        920        930        940        950        960
QALYEPCTQD IVMFLVVMLC NQNYIRNPYL VAKLVEVMFM TNPAVQPRTQ KFFEMIENHP
       970        980        990       1000       1010       1020
LSTKLLVPSL MKFYTDVEHT GATSEFYDKF TIRYHISTIF KSLWQNIAHH GTFMEEFNSG
      1030       1040       1050       1060       1070       1080
KQFVRYINML INDTTFLLDE SLESLKRIHE VQEEMKNKEQ WDQLPRDQQQ ARQSQLAQDE
      1090       1100       1110       1120       1130       1140
RVSRSYLALA TETVDMFHIL TKQVQKPFLR PELGPRLAAM LNFNLQQLCG PKCRDLKVEN
      1150       1160       1170       1180       1190       1200
PEKYGFEPKK LLDQLTDIYL QLDCARFAKA IADDQRSYSK ELFEEVISKM RKAGIKSTIA
      1210       1220       1230       1240       1250       1260
IEKFKLLAEK VEEIVAKNAR AEIDYSDAPD EFRDPLMDTL MTDPVRLPSG TIMDRSIILR
      1270       1280       1290       1300
HLLNSPTDPF NRQTLTESML EPVPELKEQI QAWMREKQNS DH         10         20         30         40         50         60
MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM
        70         80         90        100        110        120
TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV
       130        140        150        160        170        180
DVDSGIENME VDENDRREKR SLSDKEPSSG PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL
       190        200        210        220        230        240
SSLSAQFKQN PKEVFSDFKD LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIAAAARSPD
       250        260        270        280        290        300
RNLLLNTGSN PGTSPMFCSV ASFGASSLSS LYESSPAPTP SFWSSVPVMG PSLASPSRAA
       310        320        330        340        350        360
SQLAVPSTPL SPHSAASGTA AGSQPSSPRY RPYTVTHPWA SSGVSILSSS PSPPALASSP
       370        380        390        400        410        420
QAVPASSSRQ RPSSTGPPLP PASPSATSRR PSSLRISPSL GASGGASNWD SYSDHFTIET
       430        440        450        460        470        480
CKETDMLNYL IECFDRVGIE EKKAPKMCSQ PAVSQLLSNI RSQCISHTAL VLQGSLTQPR
       490        500        510        520        530        540
SLQQPSFLVP YMLCRNLPYG FIQELVRTTH QDEEVFKQIF IPILQGLALA AKECSLDSDY
       550        560        570        580        590        600
FKYPLMALGE LCETKFGKTH PVCNLVASLR LWLPKSLSPG CGRELQRLSY LGAFFSFSVF
       610        620        630        640        650        660
AEDDVKVVEK YFSGPAITLE NTRVVSQSLQ HYLELGRQEL FKILHSILLN GETREAALSY
       670        680        690        700        710        720
MAAVVNANMK KAQMQTDDRL VSTDGFMLNF LWVLQQLSTK IKLETVDPTY IFHPRCRITL
       730        740        750        760        770        780
PNDETRVNAT MEDVNDWLTE LYGDQPPFSE PKFPTECFFL TLHAHHLSIL PSCRRYIRRL
       790        800        810        820        830        840
RAIRELNRTV EDLKNNESQW KDSPLATRHR EMLKRCKTQL KKLVRCKACA DAGLLDESFL
       850        860        870        880        890        900
RRCLNFYGLL IQLLLRILDP AYPDITLPLN SDVPKVFAAL PEFYVEDVAE FLFFIVQYSP
       910        920        930        940        950        960
QALYEPCTQD IVMFLVVMLC NQNYIRNPYL VAKLVEVMFM TNPAVQPRTQ KFFEMIENHP
       970        980        990       1000       1010       1020
LSTKLLVPSL MKFYTDVEHT GATSEFYDKF TIRYHISTIF KSLWQNIAHH GTFMEEFNSG
      1030       1040       1050       1060       1070       1080
KQFVRYINML INDTTFLLDE SLESLKRIHE VQEEMKNKEQ WDQLPRDQQQ ARQSQLAQDE
      1090       1100       1110       1120       1130       1140
RVSRSYLALA TETVDMFHIL TKQVQKPFLR PELGPRLAAM LNFNLQQLCG PKCRDLKVEN
      1150       1160       1170       1180       1190       1200
PEKYGFEPKK LLDQLTDIYL QLDCARFAKA IADDQRSYSK ELFEEVISKM RKAGIKSTIA
      1210       1220       1230       1240       1250       1260
IEKFKLLAEK VEEIVAKNAR AEIDYSDAPD EFRDPLMDTL MTDPVRLPSG TIMDRSIILR
      1270       1280       1290       1300
HLLNSPTDPF NRQTLTESML EPVPELKEQI QAWMREKQNS DH         10         20         30         40         50         60
MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM
        70         80         90        100        110        120
TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV
       130        140        150        160        170        180
DVDSGIENME VDENDRREKR SLSDKEPSSG PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL
       190        200        210        220        230        240
SSLSAQFKQN PKEVFSDFKD LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIAAAARSPD
       250        260        270        280        290        300
RNLLLNTGSN PGTSPMFCSV ASFGASSLSS LYESSPAPTP SFWSSVPVMG PSLASPSRAA
       310        320        330        340        350        360
SQLAVPSTPL SPHSAASGTA AGSQPSSPRY RPYTVTHPWA SSGVSILSSS PSPPALASSP
       370        380        390        400        410        420
QAVPASSSRQ RPSSTGPPLP PASPSATSRR PSSLRISPSL GASGGASNWD SYSDHFTIET
       430        440        450        460        470        480
CKETDMLNYL IECFDRVGIE EKKAPKMCSQ PAVSQLLSNI RSQCISHTAL VLQGSLTQPR
       490        500        510        520        530        540
SLQQPSFLVP YMLCRNLPYG FIQELVRTTH QDEEVFKQIF IPILQGLALA AKECSLDSDY
       550        560        570        580        590        600
FKYPLMALGE LCETKFGKTH PVCNLVASLR LWLPKSLSPG CGRELQRLSY LGAFFSFSVF
       610        620        630        640        650        660
AEDDVKVVEK YFSGPAITLE NTRVVSQSLQ HYLELGRQEL FKILHSILLN GETREAALSY
       670        680        690        700        710        720
MAAVVNANMK KAQMQTDDRL VSTDGFMLNF LWVLQQLSTK IKLETVDPTY IFHPRCRITL
       730        740        750        760        770        780
PNDETRVNAT MEDVNDWLTE LYGDQPPFSE PKFPTECFFL TLHAHHLSIL PSCRRYIRRL
       790        800        810        820        830        840
RAIRELNRTV EDLKNNESQW KDSPLATRHR EMLKRCKTQL KKLVRCKACA DAGLLDESFL
       850        860        870        880        890        900
RRCLNFYGLL IQLLLRILDP AYPDITLPLN SDVPKVFAAL PEFYVEDVAE FLFFIVQYSP
       910        920        930        940        950        960
QALYEPCTQD IVMFLVVMLC NQNYIRNPYL VAKLVEVMFM TNPAVQPRTQ KFFEMIENHP
       970        980        990       1000       1010       1020
LSTKLLVPSL MKFYTDVEHT GATSEFYDKF TIRYHISTIF KSLWQNIAHH GTFMEEFNSG
      1030       1040       1050       1060       1070       1080
KQFVRYINML INDTTFLLDE SLESLKRIHE VQEEMKNKEQ WDQLPRDQQQ ARQSQLAQDE
      1090       1100       1110       1120       1130       1140
RVSRSYLALA TETVDMFHIL TKQVQKPFLR PELGPRLAAM LNFNLQQLCG PKCRDLKVEN
      1150       1160       1170       1180       1190       1200
PEKYGFEPKK LLDQLTDIYL QLDCARFAKA IADDQRSYSK ELFEEVISKM RKAGIKSTIA
      1210       1220       1230       1240       1250       1260
IEKFKLLAEK VEEIVAKNAR AEIDYSDAPD EFRDPLMDTL MTDPVRLPSG TIMDRSIILR
      1270       1280       1290       1300
HLLNSPTDPF NRQTLTESML EPVPELKEQI QAWMREKQNS DH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95155-1-Acetylation	MEELSA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95155-1-Acetylation	MEELSA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O95155-1-Acetylation	MEELSA...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O95155-1-Acetylation	MEELSA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O95155-1-Acetylation	MEELSA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103633
O95155-1-Acetylation	MEELSA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103634
O95155-1-unknown	MEELSA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93615
O95155-1-unknown	MEELSA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93617
O95155-54-unknown	GLNVHN...	54		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173669
O95155-54-unknown	GLNVHN...	54		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173670
O95155-54-	GLNVHN...	54			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O95155-65-unknown	SPIGAS...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173672
O95155-65-unknown	SPIGAS...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173673
O95155-65-	SPIGAS...	65			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O95155-110-unknown	GVSCEK...	110		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2785
O95155-110-unknown	GVSCEK...	110		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1508
O95155-110-unknown	GVSCEK...	110		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142969
O95155-110-unknown	GVSCEK...	110		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142970
O95155-117-unknown	MSQVDV...	117		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93616
O95155-117-unknown	MSQVDV...	117		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105741
O95155-117-unknown	MSQVDV...	117		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105742
O95155-124-unknown	SGIENM...	124		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2422
O95155-124-unknown	SGIENM...	124		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11003
O95155-124-unknown	SGIENM...	124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173675
O95155-124-unknown	SGIENM...	124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143659
O95155-124-unknown	SGIENM...	124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143660
O95155-124-	SGIENM...	124			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SMDIDG	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2785
...SMDIDG	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1508
...SMDIDG	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126177
...SMDIDG	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126178
...QVDVDS	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2422
...QVDVDS	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11003
...QVDVDS	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126901
...QVDVDS	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126902
...QNSDH	1302	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QNSDH	1302	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89234
...QNSDH	1302	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89233
...QNSDH	1302	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89235

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	109	DIDG.\|.GVSC	inferred from experiment	unknown	MEROPS	Rosen A	Mahoney JA et al.:The human homologue of the yeas... (C14.003)	11802788,
CASP3_HUMAN	109	DIDG.\|.GVSC	inferred from experiment	unknown	MEROPS	Rosen A	Mahoney JA et al.:The human homologue of the yeas... (C14.003)	11802788,
CASP6_HUMAN	123	DVDS.\|.SGIE	inferred from experiment	unknown	MEROPS	Rosen A	Mahoney JA et al.:The human homologue of the yeas... (C14.003)	11802788,
GRAB_HUMAN	123	DVDS.\|.SGIE	inferred from experiment	unknown	MEROPS	Rosen A	Mahoney JA et al.:The human homologue of the yeas... (C14.003)	11802788,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)