O95747: Serine/threonine-protein kinase OSR1

General Information

Protein names	- Serine/threonine-protein kinase OSR1 - 2.7.11.1 - Oxidative stress-responsive 1 protein
Gene names	OXSR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95747

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL EKCQTSMDEL
        70         80         90        100        110        120
LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV LDIIKHIVAK GEHKSGVLDE
       130        140        150        160        170        180
STIATILREV LEGLEYLHKN GQIHRDVKAG NILLGEDGSV QIADFGVSAF LATGGDITRN
       190        200        210        220        230        240
KVRKTFVGTP CWMAPEVMEQ VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL
       250        260        270        280        290        300
QNDPPSLETG VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL
       310        320        330        340        350        360
QEKTLQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG KAAISQLRSP
       370        380        390        400        410        420
RVKESISNSE LFPTTDPVGT LLQVPEQISA HLPQPAGQIA TQPTQVSLPP TAEPAKTAQA
       430        440        450        460        470        480
LSSGSGSQET KIPISLVLRL RNSKKELNDI RFEFTPGRDT AEGVSQELIS AGLVDGRDLV
       490        500        510        520
IVAANLQKIV EEPQSNRSVT FKLASGVEGS DIPDDGKLIG FAQLSIS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95747-2-unknown	MSEDSS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95747-2-Acetylation	SEDSSA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95747-2-Acetylation	SEDSSA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O95747-2-Acetylation	SEDSSA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O95747-2-Acetylation	SEDSSA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O95747-43-unknown	VAIKRI...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11031
O95747-193-	MAPEVM...	193			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O95747-371-acetylation	LFPTTD...	371	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O95747-422-	SSGSGS...	422			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PKKEKV	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11031
	...QLSIS	527	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	42	KEKV.\|.VAIK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)