P04350: Tubulin beta-4A chain

General Information

Protein names	- Tubulin beta-4A chain - Tubulin 5 beta - Tubulin beta-4 chain
Gene names	TUBB4A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04350

17 N-termini

19 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGNYV
        70         80         90        100        110        120
PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDAVLDVV
       130        140        150        160        170        180
RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEFP DRIMNTFSVV PSPKVSDTVV
       190        200        210        220        230        240
EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL
       250        260        270        280        290        300
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM
       310        320        330        340        350        360
AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LSVQSKNSSY FVEWIPNNVK TAVCDIPPRG
       370        380        390        400        410        420
LKMAATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
       430        440
EYQQYQDATA EEGEFEEEAE EEVA

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04350-1-unknown	MREIVH...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04350-67-unknown	DLEPGT...	67	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15285
P04350-73-unknown	MDSVRS...	73	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471880
P04350-136-unknown	THSLGG...	136	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15286
P04350-137-unknown	HSLGGG...	137	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15287
P04350-140-unknown	GGGTGS...	140	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15288
P04350-166-	TFSVVP...	166		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P04350-168-	SVVPSP...	168		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P04350-206-unknown	ALYDIC...	206	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11043
P04350-218-unknown	TTPTYG...	218	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15289
P04350-222-unknown	YGDLNH...	222	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15290
P04350-230-unknown	SATMSG...	230	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15291
P04350-241-unknown	RFPGQL...	241	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15292
P04350-252-unknown	KLAVNM...	252	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9930
P04350-254-unknown	AVNMVP...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15293
P04350-264-unknown	HFFMPG...	264	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15294
P04350-265-	FFMPGF...	265		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RAVLVD	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15285
...AKGHYT	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470627
...KGHYTE	107	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469660
...DVVRKE	122	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472375
...QGFQLT	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15286
...GFQLTH	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15287
...LTHSLG	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15288
...GTGSGM	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471880
...CIDNEA	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11043
...RTLKLT	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15289
...LTTPTY	221	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15290
...LNHLVS	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15291
...NHLVSA	230	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469936
...NHLVSA	230	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470983
...VTTCLR	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15292
...NADLRK	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9930
...DLRKLA	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15293
...VNMVPF	259	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472481
...PFPRLH	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15294
...EEEVA	444	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HTRA2_HUMAN	66	VLVD.\|.DLEP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	135	FQLT.\|.THSL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	136	QLTH.\|.HSLG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	139	HSLG.\|.GGGT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	205	DNEA.\|.ALYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	217	LKLT.\|.TTPT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	221	TPTY.\|.YGDL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	229	HLVS.\|.SATM	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	240	TCLR.\|.RFPG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	251	DLRK.\|.KLAV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	253	RKLA.\|.AVNM	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	263	PRLH.\|.HFFM	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,

TopFIND

P04350: Tubulin beta-4A chain

General Information

17

N-termini

19

C-termini

12

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

17 N-termini - 19 C-termini - 12 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates