P05423: DNA-directed RNA polymerase III subunit RPC4

General Information

Protein names	- DNA-directed RNA polymerase III subunit RPC4 - RNA polymerase III subunit C4 - DNA-directed RNA polymerase III subunit D - Protein BN51 - RNA polymerase III 47 kDa subunit - RPC53 homolog
Gene names	POLR3D
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05423

5 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEGNAAGEP STPGGPRPLL TGARGLIGRR PAPPLTPGRL PSIRSRDLTL GGVKKKTFTP
        70         80         90        100        110        120
NIISRKIKEE PKEEVTVKKE KRERDRDRQR EGHGRGRGRP EVIQSHSIFE QGPAEMMKKK
       130        140        150        160        170        180
GNWDKTVDVS DMGPSHIINI KKEKRETDEE TKQILRMLEK DDFLDDPGLR NDTRNMPVQL
       190        200        210        220        230        240
PLAHSGWLFK EENDEPDVKP WLAGPKEEDM EVDIPAVKVK EEPRDEEEEA KMKAPPKAAR
       250        260        270        280        290        300
KTPGLPKDVS VAELLRELSL TKEEELLFLQ LPDTLPGQPP TQDIKPIKTE VQGEDGQVVL
       310        320        330        340        350        360
IKQEKDREAK LAENACTLAD LTEGQVGKLL IRKSGRVQLL LGKVTLDVTM GTACSFLQEL
       370        380        390
VSVGLGDSRT GEMTVLGHVK HKLVCSPDFE SLLDHKHR

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P05423-2-unknown	MSEGNA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P05423-2-Acetylation	SEGNAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P05423-2-Acetylation	SEGNAA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P05423-162-unknown	DFLDDP...	162		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11047
P05423-216-	AVKVKE...	216			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P05423-216-	AVKVKE...	216			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P05423-301-unknown	IKQEKD...	301		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13915

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MLEKDD	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11047
...AGPKEE	207	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429677
...GQVVLI	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13915
...DHKHR	398	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	161	EKDD.\|.DFLD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	300	VVLI.\|.IKQE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)