P09486: SPARC

General Information

Protein names	- SPARC - Basement-membrane protein 40 - BM-40 - Osteonectin - ON - Secreted protein acidic and rich in cysteine
Gene names	SPARC
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P09486

12 N-termini

15 C-termini

22 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV EVGEFDDGAE
        70         80         90        100        110        120
ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS CPAPIGEFEK VCSNDNKTFD
       130        140        150        160        170        180
SSCHFFATKC TLEGTKKGHK LHLDYIGPCK YIPPCLDSEL TEFPLRMRDW LKNVLVTLYE
       190        200        210        220        230        240
RDEDNNLLTE KQKLRVKKIH ENEKRLEAGD HPVELLARDF EKNYNMYIFP VHWQFGQLDQ
       250        260        270        280        290        300
HPIDGYLSHT ELAPLRAPLI PMEHCTTRFF ETCDLDNDKY IALDEWAGCF GIKQKDIDKD

LVI

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 15 C-termini - 22 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P09486-18-unknown	APQQEA...	18	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P09486-21-unknown	QEALPD...	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5007
P09486-38-unknown	VTEVSV...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23830
P09486-38-unknown	VTEVSV...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22623
P09486-38-unknown	VTEVSV...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24014
P09486-48-unknown	VQVEVG...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25667
P09486-48-unknown	VQVEVG...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22624
P09486-48-unknown	VQVEVG...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21376
P09486-50-unknown	VEVGEF...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25668
P09486-50-unknown	VEVGEF...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21377
P09486-55-unknown	FDDGAE...	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24015
P09486-92-unknown	MCVCQD...	92	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440127
P09486-92-unknown	MCVCQD...	92	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428119
P09486-105-unknown	IGEFEK...	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23831
P09486-167-unknown	MRDWLK...	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23832
P09486-196-unknown	VKKIHE...	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5008
P09486-215-unknown	LLARDF...	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23833
P09486-215-unknown	LLARDF...	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25669
P09486-215-unknown	LLARDF...	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22625
P09486-215-unknown	LLARDF...	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21378
P09486-215-unknown	LLARDF...	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24016
P09486-255-unknown	LRAPLI...	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23834
P09486-255-unknown	LRAPLI...	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22626
P09486-255-unknown	LRAPLI...	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21379
P09486-255-unknown	LRAPLI...	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24017

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LAAPQQ	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5007
...ETVAEV	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23830
...ETVAEV	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22623
...ETVAEV	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24014
...VGANPV	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25667
...VGANPV	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22624
...VGANPV	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21376
...ANPVQV	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25668
...ANPVQV	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21377
...QVEVGE	53	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429152
...VEVGEF	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24015
...SCPAPI	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23831
...EFEKVC	111	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444998
...EFPLRM	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23832
...KQKLRV	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5008
...NEKRLE	206	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428119
...DHPVEL	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23833
...DHPVEL	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25669
...DHPVEL	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22625
...DHPVEL	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21378
...DHPVEL	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24016
...GQLDQH	240	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440127
...TELAPL	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23834
...TELAPL	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22626
...TELAPL	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21379
...TELAPL	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24017
...KDLVI	303	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATK_HUMAN	20	APQQ.\|.QEAL	inferred from experiment	unknown	MEROPS	Levy MA	Bossard MJ et al.:Proteolytic activity of human o... (C01.036)	8647860,
MMP3_HUMAN	37	VAEV.\|.VTEV	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP2_HUMAN	37	VAEV.\|.VTEV	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP7_HUMAN	37	VAEV.\|.VTEV	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP9_HUMAN	47	ANPV.\|.VQVE	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP2_HUMAN	47	ANPV.\|.VQVE	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP13_HUMAN	47	ANPV.\|.VQVE	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP9_HUMAN	49	PVQV.\|.VEVG	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP13_HUMAN	49	PVQV.\|.VEVG	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP7_HUMAN	54	VGEF.\|.FDDG	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP3_HUMAN	104	PAPI.\|.IGEF	inferred from experiment	unknown	MEROPS	Bassuk JA	Sage EH et al.:Cleavage of the matricellular p... (M10.005)	12867428,
MMP3_HUMAN	166	PLRM.\|.MRDW	inferred from experiment	unknown	MEROPS	Bassuk JA	Sage EH et al.:Cleavage of the matricellular p... (M10.005)	12867428,
CATK_HUMAN	195	KLRV.\|.VKKI	inferred from experiment	unknown	MEROPS	Levy MA	Bossard MJ et al.:Proteolytic activity of human o... (C01.036)	8647860,
MMP3_HUMAN	214	PVEL.\|.LLAR	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP9_HUMAN	214	PVEL.\|.LLAR	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP2_HUMAN	214	PVEL.\|.LLAR	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP13_HUMAN	214	PVEL.\|.LLAR	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP7_HUMAN	214	PVEL.\|.LLAR	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP3_HUMAN	254	LAPL.\|.LRAP	inferred from experiment	unknown	MEROPS	Bassuk JA	Sage EH et al.:Cleavage of the matricellular p... (M10.005)	12867428,
MMP2_HUMAN	254	LAPL.\|.LRAP	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP13_HUMAN	254	LAPL.\|.LRAP	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,
MMP7_HUMAN	254	LAPL.\|.LRAP	inferred from experiment	unknown	MEROPS	Timpl R	Sasaki T et al.:Limited cleavage of extracellul... (M10.013)	9083057,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)