P11274: Breakpoint cluster region protein {ECO:0000305}
Protein names | - Breakpoint cluster region protein {ECO:0000305} - 2.7.11.1 {ECO:0000269|PubMed:1657398} - Renal carcinoma antigen NY-REN-26 |
---|---|
Gene names | BCR |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P11274 |
9
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ
70 80 90 100 110 120
TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE
130 140 150 160 170 180
GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV
190 200 210 220 230 240
EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC
250 260 270 280 290 300
GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
310 320 330 340 350 360
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS SRVSPSPTTY
370 380 390 400 410 420
RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS EATIVGVRKT GQIWPNDGEG
430 440 450 460 470 480
AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ DGLPYIDDSP SSSPHLSSKG RGSRDALVSG
490 500 510 520 530 540
ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS
550 560 570 580 590 600
QQIETIFFKV PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV
610 620 630 640 650 660
AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV TRSTLVLHDL
670 680 690 700 710 720
LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT VKKGEHRQLL KDSFMVELVE
730 740 750 760 770 780
GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP
790 800 810 820 830 840
DEELDALKIK ISQIKNDIQR EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN
850 860 870 880 890 900
GKSYTFLISS DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN
910 920 930 940 950 960
KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY RDTAEPNWNE
970 980 990 1000 1010 1020
EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK GQVQLDPQAL QDRDWQRTVI
1030 1040 1050 1060 1070 1080
AMNGIEVKLS VKFNSREFSL KRMPSRKQTG VFGVKIAVVT KRERSKVPYI VRQCVEEIER
1090 1100 1110 1120 1130 1140
RGMEEVGIYR VSGVATDIQA LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF
1150 1160 1170 1180 1190 1200
TDEFYPNFAE GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL
1210 1220 1230 1240 1250 1260
HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL QLEAIPAPDS
1270
KRQSILFSTE V
Isoforms
- Isoform 2 of Breakpoint cluster region proteinSequence View
10 20 30 40 50 60
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ
70 80 90 100 110 120
TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE
130 140 150 160 170 180
GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV
190 200 210 220 230 240
EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC
250 260 270 280 290 300
GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
310 320 330 340 350 360
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS SRVSPSPTTY
370 380 390 400 410 420
RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS EATIVGVRKT GQIWPNDGEG
430 440 450 460 470 480
AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ DGLPYIDDSP SSSPHLSSKG RGSRDALVSG
490 500 510 520 530 540
ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS
550 560 570 580 590 600
QQIETIFFKV PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV
610 620 630 640 650 660
AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV TRSTLVLHDL
670 680 690 700 710 720
LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT VKKGEHRQLL KDSFMVELVE
730 740 750 760 770 780
GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP
790 800 810 820 830 840
DEELDALKIK ISQIKNDIQR EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN
850 860 870 880 890 900
GKSYTFLISS DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN
910 920 930 940 950 960
KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY RDTAEPNWNE
970 980 990 1000 1010 1020
EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK GQVQLDPQAL QDRDWQRTVI
1030 1040 1050 1060 1070 1080
AMNGIEVKLS VKFNSREFSL KRMPSRKQTG VFGVKIAVVT KRERSKVPYI VRQCVEEIER
1090 1100 1110 1120 1130 1140
RGMEEVGIYR VSGVATDIQA LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF
1150 1160 1170 1180 1190 1200
TDEFYPNFAE GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL
1210 1220 1230 1240 1250 1260
HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL QLEAIPAPDS
1270
KRQSILFSTE V
Protein Neighborhood
Domains & Features
9 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P11274-1- | MVDPVG... | 1 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P11274-1- | MVDPVG... | 1 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P11274-1-unknown | MVDPVG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt68349 | |||
P11274-1-Acetylation | MVDPVG... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P11274-1-Acetylation | MVDPVG... | 1 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
P11274-1-Acetylation | MVDPVG... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt109798 | ||
P11274-27- | SVGDIE... | 27 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P11274-27-unknown | SVGDIE... | 27 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174139 | |||
P11274-244-unknown | GDYEDA... | 244 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11171 | |||
P11274-244-unknown | GDYEDA... | 244 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148250 | |||
P11274-244- | GDYEDA... | 244 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P11274-244- | GDYEDA... | 244 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P11274-244- | GDYEDA... | 244 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P11274-246-unknown | YEDAEL... | 246 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11173 | |||
P11274-246-unknown | YEDAEL... | 246 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148300 | |||
P11274-265-unknown | GGSRPP... | 265 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11175 | |||
P11274-265-unknown | GGSRPP... | 265 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148997 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SCGVDG | 243 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11171 | |||
...SCGVDG | 243 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131616 | |||
...GVDGDY | 245 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11173 | |||
...GVDGDY | 245 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131670 | |||
...LIDANG | 264 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11175 | |||
...LIDANG | 264 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132379 | |||
...FSTEV | 1271 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...FSTEV | 1271 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt63967 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 243 | GVDG.|.GDYE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
GRAB_HUMAN | 245 | DGDY.|.YEDA | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 264 | DANG.|.GGSR | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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