P11717: Cation-independent mannose-6-phosphate receptor

General Information

Protein names	- Cation-independent mannose-6-phosphate receptor - CI Man-6-P receptor - CI-MPR - M6PR - 300 kDa mannose 6-phosphate receptor - MPR 300 - Insulin-like growth factor 2 receptor - Insulin-like growth factor II receptor - IGF-II receptor - M6P/IGF2 receptor - M6P/IGF2R - CD222
Gene names	IGF2R
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P11717

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGAAAGRSPH LGPAPARRPQ RSLLLLQLLL LVAAPGSTQA QAAPFPELCS YTWEAVDTKN
        70         80         90        100        110        120
NVLYKINICG SVDIVQCGPS SAVCMHDLKT RTYHSVGDSV LRSATRSLLE FNTTVSCDQQ
       130        140        150        160        170        180
GTNHRVQSSI AFLCGKTLGT PEFVTATECV HYFEWRTTAA CKKDIFKANK EVPCYVFDEE
       190        200        210        220        230        240
LRKHDLNPLI KLSGAYLVDD SDPDTSLFIN VCRDIDTLRD PGSQLRACPP GTAACLVRGH
       250        260        270        280        290        300
QAFDVGQPRD GLKLVRKDRL VLSYVREEAG KLDFCDGHSP AVTITFVCPS ERREGTIPKL
       310        320        330        340        350        360
TAKSNCRYEI EWITEYACHR DYLESKTCSL SGEQQDVSID LTPLAQSGGS SYISDGKEYL
       370        380        390        400        410        420
FYLNVCGETE IQFCNKKQAA VCQVKKSDTS QVKAAGRYHN QTLRYSDGDL TLIYFGGDEC
       430        440        450        460        470        480
SSGFQRMSVI NFECNKTAGN DGKGTPVFTG EVDCTYFFTW DTEYACVKEK EDLLCGATDG
       490        500        510        520        530        540
KKRYDLSALV RHAEPEQNWE AVDGSQTETE KKHFFINICH RVLQEGKARG CPEDAAVCAV
       550        560        570        580        590        600
DKNGSKNLGK FISSPMKEKG NIQLSYSDGD DCGHGKKIKT NITLVCKPGD LESAPVLRTS
       610        620        630        640        650        660
GEGGCFYEFE WHTAAACVLS KTEGENCTVF DSQAGFSFDL SPLTKKNGAY KVETKKYDFY
       670        680        690        700        710        720
INVCGPVSVS PCQPDSGACQ VAKSDEKTWN LGLSNAKLSY YDGMIQLNYR GGTPYNNERH
       730        740        750        760        770        780
TPRATLITFL CDRDAGVGFP EYQEEDNSTY NFRWYTSYAC PEEPLECVVT DPSTLEQYDL
       790        800        810        820        830        840
SSLAKSEGGL GGNWYAMDNS GEHVTWRKYY INVCRPLNPV PGCNRYASAC QMKYEKDQGS
       850        860        870        880        890        900
FTEVVSISNL GMAKTGPVVE DSGSLLLEYV NGSACTTSDG RQTTYTTRIH LVCSRGRLNS
       910        920        930        940        950        960
HPIFSLNWEC VVSFLWNTEA ACPIQTTTDT DQACSIRDPN SGFVFNLNPL NSSQGYNVSG
       970        980        990       1000       1010       1020
IGKIFMFNVC GTMPVCGTIL GKPASGCEAE TQTEELKNWK PARPVGIEKS LQLSTEGFIT
      1030       1040       1050       1060       1070       1080
LTYKGPLSAK GTADAFIVRF VCNDDVYSGP LKFLHQDIDS GQGIRNTYFE FETALACVPS
      1090       1100       1110       1120       1130       1140
PVDCQVTDLA GNEYDLTGLS TVRKPWTAVD TSVDGRKRTF YLSVCNPLPY IPGCQGSAVG
      1150       1160       1170       1180       1190       1200
SCLVSEGNSW NLGVVQMSPQ AAANGSLSIM YVNGDKCGNQ RFSTRITFEC AQISGSPAFQ
      1210       1220       1230       1240       1250       1260
LQDGCEYVFI WRTVEACPVV RVEGDNCEVK DPRHGNLYDL KPLGLNDTIV SAGEYTYYFR
      1270       1280       1290       1300       1310       1320
VCGKLSSDVC PTSDKSKVVS SCQEKREPQG FHKVAGLLTQ KLTYENGLLK MNFTGGDTCH
      1330       1340       1350       1360       1370       1380
KVYQRSTAIF FYCDRGTQRP VFLKETSDCS YLFEWRTQYA CPPFDLTECS FKDGAGNSFD
      1390       1400       1410       1420       1430       1440
LSSLSRYSDN WEAITGTGDP EHYLINVCKS LAPQAGTEPC PPEAAACLLG GSKPVNLGRV
      1450       1460       1470       1480       1490       1500
RDGPQWRDGI IVLKYVDGDL CPDGIRKKST TIRFTCSESQ VNSRPMFISA VEDCEYTFAW
      1510       1520       1530       1540       1550       1560
PTATACPMKS NEHDDCQVTN PSTGHLFDLS SLSGRAGFTA AYSEKGLVYM SICGENENCP
      1570       1580       1590       1600       1610       1620
PGVGACFGQT RISVGKANKR LRYVDQVLQL VYKDGSPCPS KSGLSYKSVI SFVCRPEARP
      1630       1640       1650       1660       1670       1680
TNRPMLISLD KQTCTLFFSW HTPLACEQAT ECSVRNGSSI VDLSPLIHRT GGYEAYDESE
      1690       1700       1710       1720       1730       1740
DDASDTNPDF YINICQPLNP MHGVPCPAGA AVCKVPIDGP PIDIGRVAGP PILNPIANEI
      1750       1760       1770       1780       1790       1800
YLNFESSTPC LADKHFNYTS LIAFHCKRGV SMGTPKLLRT SECDFVFEWE TPVVCPDEVR
      1810       1820       1830       1840       1850       1860
MDGCTLTDEQ LLYSFNLSSL STSTFKVTRD SRTYSVGVCT FAVGPEQGGC KDGGVCLLSG
      1870       1880       1890       1900       1910       1920
TKGASFGRLQ SMKLDYRHQD EAVVLSYVNG DRCPPETDDG VPCVFPFIFN GKSYEECIIE
      1930       1940       1950       1960       1970       1980
SRAKLWCSTT ADYDRDHEWG FCRHSNSYRT SSIIFKCDED EDIGRPQVFS EVRGCDVTFE
      1990       2000       2010       2020       2030       2040
WKTKVVCPPK KLECKFVQKH KTYDLRLLSS LTGSWSLVHN GVSYYINLCQ KIYKGPLGCS
      2050       2060       2070       2080       2090       2100
ERASICRRTT TGDVQVLGLV HTQKLGVIGD KVVVTYSKGY PCGGNKTASS VIELTCTKTV
      2110       2120       2130       2140       2150       2160
GRPAFKRFDI DSCTYYFSWD SRAACAVKPQ EVQMVNGTIT NPINGKSFSL GDIYFKLFRA
      2170       2180       2190       2200       2210       2220
SGDMRTNGDN YLYEIQLSSI TSSRNPACSG ANICQVKPND QHFSRKVGTS DKTKYYLQDG
      2230       2240       2250       2260       2270       2280
DLDVVFASSS KCGKDKTKSV SSTIFFHCDP LVEDGIPEFS HETADCQYLF SWYTSAVCPL
      2290       2300       2310       2320       2330       2340
GVGFDSENPG DDGQMHKGLS ERSQAVGAVL SLLLVALTCC LLALLLYKKE RRETVISKLT
      2350       2360       2370       2380       2390       2400
TCCRRSSNVS YKYSKVNKEE ETDENETEWL MEEIQLPPPR QGKEGQENGH ITTKSVKALS
      2410       2420       2430       2440       2450       2460
SLHGDDQDSE DEVLTIPEVK VHSGRGAGAE SSHPVRNAQS NALQEREDDR VGLVRGEKAR
      2470       2480       2490
KGKSSSAQQK TVSSTKLVSF HDDSDEDLLH I

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P11717-41-unknown	QAAPFP...	41	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11717-501-unknown	AVDGSQ...	501	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7292
P11717-2401-	SLHGDD...	2401		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P11717-2401-	SLHGDD...	2401		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P11717-2401-	SLHGDD...	2401		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P11717-2401-	SLHGDD...	2401		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EQNWEA	500	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7292
	...DLLHI	2491	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	500	NWEA.\|.AVDG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)