P12270: Nucleoprotein TPR

General Information

Protein names	- Nucleoprotein TPR - Megator - NPC-associated intranuclear protein - Translocated promoter region protein
Gene names	TPR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12270

9 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAVLQQVLE RTELNKLPKS VQNKLEKFLA DQQSEIDGLK GRHEKFKVES EQQYFEIEKR
        70         80         90        100        110        120
LSHSQERLVN ETRECQSLRL ELEKLNNQLK ALTEKNKELE IAQDRNIAIQ SQFTRTKEEL
       130        140        150        160        170        180
EAEKRDLIRT NERLSQELEY LTEDVKRLNE KLKESNTTKG ELQLKLDELQ ASDVSVKYRE
       190        200        210        220        230        240
KRLEQEKELL HSQNTWLNTE LKTKTDELLA LGREKGNEIL ELKCNLENKK EEVSRLEEQM
       250        260        270        280        290        300
NGLKTSNEHL QKHVEDLLTK LKEAKEQQAS MEEKFHNELN AHIKLSNLYK SAADDSEAKS
       310        320        330        340        350        360
NELTRAVEEL HKLLKEAGEA NKAIQDHLLE VEQSKDQMEK EMLEKIGRLE KELENANDLL
       370        380        390        400        410        420
SATKRKGAIL SEEELAAMSP TAAAVAKIVK PGMKLTELYN AYVETQDQLL LEKLENKRIN
       430        440        450        460        470        480
KYLDEIVKEV EAKAPILKRQ REEYERAQKA VASLSVKLEQ AMKEIQRLQE DTDKANKQSS
       490        500        510        520        530        540
VLERDNRRME IQVKDLSQQI RVLLMELEEA RGNHVIRDEE VSSADISSSS EVISQHLVSY
       550        560        570        580        590        600
RNIEELQQQN QRLLVALREL GETREREEQE TTSSKITELQ LKLESALTEL EQLRKSRQHQ
       610        620        630        640        650        660
MQLVDSIVRQ RDMYRILLSQ TTGVAIPLHA SSLDDVSLAS TPKRPSTSQT VSTPAPVPVI
       670        680        690        700        710        720
ESTEAIEAKA ALKQLQEIFE NYKKEKAENE KIQNEQLEKL QEQVTDLRSQ NTKISTQLDF
       730        740        750        760        770        780
ASKRYEMLQD NVEGYRREIT SLHERNQKLT ATTQKQEQII NTMTQDLRGA NEKLAVAEVR
       790        800        810        820        830        840
AENLKKEKEM LKLSEVRLSQ QRESLLAEQR GQNLLLTNLQ TIQGILERSE TETKQRLSSQ
       850        860        870        880        890        900
IEKLEHEISH LKKKLENEVE QRHTLTRNLD VQLLDTKRQL DTETNLHLNT KELLKNAQKE
       910        920        930        940        950        960
IATLKQHLSN MEVQVASQSS QRTGKGQPSN KEDVDDLVSQ LRQTEEQVND LKERLKTSTS
       970        980        990       1000       1010       1020
NVEQYQAMVT SLEESLNKEK QVTEEVRKNI EVRLKESAEF QTQLEKKLME VEKEKQELQD
      1030       1040       1050       1060       1070       1080
DKRRAIESME QQLSELKKTL SSVQNEVQEA LQRASTALSN EQQARRDCQE QAKIAVEAQN
      1090       1100       1110       1120       1130       1140
KYERELMLHA ADVEALQAAK EQVSKMASVR QHLEETTQKA ESQLLECKAS WEERERMLKD
      1150       1160       1170       1180       1190       1200
EVSKCVCRCE DLEKQNRLLH DQIEKLSDKV VASVKEGVQG PLNVSLSEEG KSQEQILEIL
      1210       1220       1230       1240       1250       1260
RFIRREKEIA ETRFEVAQVE SLRYRQRVEL LERELQELQD SLNAEREKVQ VTAKTMAQHE
      1270       1280       1290       1300       1310       1320
ELMKKTETMN VVMETNKMLR EEKERLEQDL QQMQAKVRKL ELDILPLQEA NAELSEKSGM
      1330       1340       1350       1360       1370       1380
LQAEKKLLEE DVKRWKARNQ HLVSQQKDPD TEEYRKLLSE KEVHTKRIQQ LTEEIGRLKA
      1390       1400       1410       1420       1430       1440
EIARSNASLT NNQNLIQSLK EDLNKVRTEK ETIQKDLDAK IIDIQEKVKT ITQVKKIGRR
      1450       1460       1470       1480       1490       1500
YKTQYEELKA QQDKVMETSA QSSGDHQEQH VSVQEMQELK ETLNQAETKS KSLESQVENL
      1510       1520       1530       1540       1550       1560
QKTLSEKETE ARNLQEQTVQ LQSELSRLRQ DLQDRTTQEE QLRQQITEKE EKTRKAIVAA
      1570       1580       1590       1600       1610       1620
KSKIAHLAGV KDQLTKENEE LKQRNGALDQ QKDELDVRIT ALKSQYEGRI SRLERELREH
      1630       1640       1650       1660       1670       1680
QERHLEQRDE PQEPSNKVPE QQRQITLKTT PASGERGIAS TSDPPTANIK PTPVVSTPSK
      1690       1700       1710       1720       1730       1740
VTAAAMAGNK STPRASIRPM VTPATVTNPT TTPTATVMPT TQVESQEAMQ SEGPVEHVPV
      1750       1760       1770       1780       1790       1800
FGSTSGSVRS TSPNVQPSIS QPILTVQQQT QATAFVQPTQ QSHPQIEPAN QELSSNIVEV
      1810       1820       1830       1840       1850       1860
VQSSPVERPS TSTAVFGTVS ATPSSSLPKR TREEEEDSTI EASDQVSDDT VEMPLPKKLK
      1870       1880       1890       1900       1910       1920
SVTPVGTEEE VMAEESTDGE VETQVYNQDS QDSIGEGVTQ GDYTPMEDSE ETSQSLQIDL
      1930       1940       1950       1960       1970       1980
GPLQSDQQTT TSSQDGQGKG DDVIVIDSDD EEEDDDENDG EHEDYEEDEE DDDDDEDDTG
      1990       2000       2010       2020       2030       2040
MGDEGEDSNE GTGSADGNDG YEADDAEGGD GTDPGTETEE SMGGGEGNHR AADSQNSGEG
      2050       2060       2070       2080       2090       2100
NTGAAESSFS QEVSREQQPS SASERQAPRA PQSPRRPPHP LPPRLTIHAP PQELGPPVQR
      2110       2120       2130       2140       2150       2160
IQMTRRQSVG RGLQLTPGIG GMQQHFFDDE DRTVPSTPTL VVPHRTDGFA EAIHSPQVAG
      2170       2180       2190       2200       2210       2220
VPRFRFGPPE DMPQTSSSHS DLGQLASQGG LGMYETPLFL AHEEESGGRS VPTTPLQVAA
      2230       2240       2250       2260       2270       2280
PVTVFTESTT SDASEHASQS VPMVTTSTGT LSTTNETATG DDGDEVFVEA ESEGISSEAG
      2290       2300       2310       2320       2330       2340
LEIDSQQEEE PVQASDESDL PSTSQDPPSS SSVDTSSSQP KPFRRVRLQT TLRQGVRGRQ
      2350       2360
FNRQRGVSHA MGGRGGINRG NIN

Isoforms

- Isoform 2 of Nucleoprotein TPR

Sequence View

        10         20         30         40         50         60
MAAVLQQVLE RTELNKLPKS VQNKLEKFLA DQQSEIDGLK GRHEKFKVES EQQYFEIEKR
        70         80         90        100        110        120
LSHSQERLVN ETRECQSLRL ELEKLNNQLK ALTEKNKELE IAQDRNIAIQ SQFTRTKEEL
       130        140        150        160        170        180
EAEKRDLIRT NERLSQELEY LTEDVKRLNE KLKESNTTKG ELQLKLDELQ ASDVSVKYRE
       190        200        210        220        230        240
KRLEQEKELL HSQNTWLNTE LKTKTDELLA LGREKGNEIL ELKCNLENKK EEVSRLEEQM
       250        260        270        280        290        300
NGLKTSNEHL QKHVEDLLTK LKEAKEQQAS MEEKFHNELN AHIKLSNLYK SAADDSEAKS
       310        320        330        340        350        360
NELTRAVEEL HKLLKEAGEA NKAIQDHLLE VEQSKDQMEK EMLEKIGRLE KELENANDLL
       370        380        390        400        410        420
SATKRKGAIL SEEELAAMSP TAAAVAKIVK PGMKLTELYN AYVETQDQLL LEKLENKRIN
       430        440        450        460        470        480
KYLDEIVKEV EAKAPILKRQ REEYERAQKA VASLSVKLEQ AMKEIQRLQE DTDKANKQSS
       490        500        510        520        530        540
VLERDNRRME IQVKDLSQQI RVLLMELEEA RGNHVIRDEE VSSADISSSS EVISQHLVSY
       550        560        570        580        590        600
RNIEELQQQN QRLLVALREL GETREREEQE TTSSKITELQ LKLESALTEL EQLRKSRQHQ
       610        620        630        640        650        660
MQLVDSIVRQ RDMYRILLSQ TTGVAIPLHA SSLDDVSLAS TPKRPSTSQT VSTPAPVPVI
       670        680        690        700        710        720
ESTEAIEAKA ALKQLQEIFE NYKKEKAENE KIQNEQLEKL QEQVTDLRSQ NTKISTQLDF
       730        740        750        760        770        780
ASKRYEMLQD NVEGYRREIT SLHERNQKLT ATTQKQEQII NTMTQDLRGA NEKLAVAEVR
       790        800        810        820        830        840
AENLKKEKEM LKLSEVRLSQ QRESLLAEQR GQNLLLTNLQ TIQGILERSE TETKQRLSSQ
       850        860        870        880        890        900
IEKLEHEISH LKKKLENEVE QRHTLTRNLD VQLLDTKRQL DTETNLHLNT KELLKNAQKE
       910        920        930        940        950        960
IATLKQHLSN MEVQVASQSS QRTGKGQPSN KEDVDDLVSQ LRQTEEQVND LKERLKTSTS
       970        980        990       1000       1010       1020
NVEQYQAMVT SLEESLNKEK QVTEEVRKNI EVRLKESAEF QTQLEKKLME VEKEKQELQD
      1030       1040       1050       1060       1070       1080
DKRRAIESME QQLSELKKTL SSVQNEVQEA LQRASTALSN EQQARRDCQE QAKIAVEAQN
      1090       1100       1110       1120       1130       1140
KYERELMLHA ADVEALQAAK EQVSKMASVR QHLEETTQKA ESQLLECKAS WEERERMLKD
      1150       1160       1170       1180       1190       1200
EVSKCVCRCE DLEKQNRLLH DQIEKLSDKV VASVKEGVQG PLNVSLSEEG KSQEQILEIL
      1210       1220       1230       1240       1250       1260
RFIRREKEIA ETRFEVAQVE SLRYRQRVEL LERELQELQD SLNAEREKVQ VTAKTMAQHE
      1270       1280       1290       1300       1310       1320
ELMKKTETMN VVMETNKMLR EEKERLEQDL QQMQAKVRKL ELDILPLQEA NAELSEKSGM
      1330       1340       1350       1360       1370       1380
LQAEKKLLEE DVKRWKARNQ HLVSQQKDPD TEEYRKLLSE KEVHTKRIQQ LTEEIGRLKA
      1390       1400       1410       1420       1430       1440
EIARSNASLT NNQNLIQSLK EDLNKVRTEK ETIQKDLDAK IIDIQEKVKT ITQVKKIGRR
      1450       1460       1470       1480       1490       1500
YKTQYEELKA QQDKVMETSA QSSGDHQEQH VSVQEMQELK ETLNQAETKS KSLESQVENL
      1510       1520       1530       1540       1550       1560
QKTLSEKETE ARNLQEQTVQ LQSELSRLRQ DLQDRTTQEE QLRQQITEKE EKTRKAIVAA
      1570       1580       1590       1600       1610       1620
KSKIAHLAGV KDQLTKENEE LKQRNGALDQ QKDELDVRIT ALKSQYEGRI SRLERELREH
      1630       1640       1650       1660       1670       1680
QERHLEQRDE PQEPSNKVPE QQRQITLKTT PASGERGIAS TSDPPTANIK PTPVVSTPSK
      1690       1700       1710       1720       1730       1740
VTAAAMAGNK STPRASIRPM VTPATVTNPT TTPTATVMPT TQVESQEAMQ SEGPVEHVPV
      1750       1760       1770       1780       1790       1800
FGSTSGSVRS TSPNVQPSIS QPILTVQQQT QATAFVQPTQ QSHPQIEPAN QELSSNIVEV
      1810       1820       1830       1840       1850       1860
VQSSPVERPS TSTAVFGTVS ATPSSSLPKR TREEEEDSTI EASDQVSDDT VEMPLPKKLK
      1870       1880       1890       1900       1910       1920
SVTPVGTEEE VMAEESTDGE VETQVYNQDS QDSIGEGVTQ GDYTPMEDSE ETSQSLQIDL
      1930       1940       1950       1960       1970       1980
GPLQSDQQTT TSSQDGQGKG DDVIVIDSDD EEEDDDENDG EHEDYEEDEE DDDDDEDDTG
      1990       2000       2010       2020       2030       2040
MGDEGEDSNE GTGSADGNDG YEADDAEGGD GTDPGTETEE SMGGGEGNHR AADSQNSGEG
      2050       2060       2070       2080       2090       2100
NTGAAESSFS QEVSREQQPS SASERQAPRA PQSPRRPPHP LPPRLTIHAP PQELGPPVQR
      2110       2120       2130       2140       2150       2160
IQMTRRQSVG RGLQLTPGIG GMQQHFFDDE DRTVPSTPTL VVPHRTDGFA EAIHSPQVAG
      2170       2180       2190       2200       2210       2220
VPRFRFGPPE DMPQTSSSHS DLGQLASQGG LGMYETPLFL AHEEESGGRS VPTTPLQVAA
      2230       2240       2250       2260       2270       2280
PVTVFTESTT SDASEHASQS VPMVTTSTGT LSTTNETATG DDGDEVFVEA ESEGISSEAG
      2290       2300       2310       2320       2330       2340
LEIDSQQEEE PVQASDESDL PSTSQDPPSS SSVDTSSSQP KPFRRVRLQT TLRQGVRGRQ
      2350       2360
FNRQRGVSHA MGGRGGINRG NIN

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P12270-2-unknown	MAAVLQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12270-2-Acetylation	AAVLQQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12270-2-Acetylation	AAVLQQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P12270-2-Acetylation	AAVLQQ...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P12270-2-Acetylation	AAVLQQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P12270-929-	SNKEDV...	929			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P12270-1730-unknown	QSEGPV...	1730		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13969
P12270-1821-	ATPSSS...	1821			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P12270-2000-	GYEADD...	2000			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P12270-2134-unknown	VPSTPT...	2134			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P12270-2148-	GFAEAI...	2148			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P12270-2148-unknown	GFAEAI...	2148		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1147

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NETREC	74	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408103
...SQEAMQ	1729	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13969
...PHRTDG	2147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1147
...RGNIN	2363	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	1729	EAMQ.\|.QSEG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP1_HUMAN	2147	RTDG.\|.GFAE	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

TopFIND

P12270: Nucleoprotein TPR

General Information

9

N-termini

4

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates