P14317: Hematopoietic lineage cell-specific protein
Protein names | - Hematopoietic lineage cell-specific protein - Hematopoietic cell-specific LYN substrate 1 - LckBP1 - p75 |
---|---|
Gene names | HCLS1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P14317 |
34
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK
70 80 90 100 110 120
VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF
130 140 150 160 170 180
GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKWDK AALGYDYKGE
190 200 210 220 230 240
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGTRGLKA
250 260 270 280 290 300
KFESMAEEKR KREEEEKAQQ VARRQQERKA VTKRSPEAPQ PVIAMEEPAV PAPLPKKISS
310 320 330 340 350 360
EAWPPVGTPP SSESEPVRTS REHPVPLLPI RQTLPEDNEE PPALPPRTLE GLQVEEEPVY
370 380 390 400 410 420
EAEPEPEPEP EPEPENDYED VEEMDRHEQE DEPEGDYEEV LEPEDSSFSS ALAGSSGCPA
430 440 450 460 470 480
GAGAGAVALG ISAVAVYDYQ GEGSDELSFD PDDVITDIEM VDEGWWRGRC HGHFGLFPAN
YVKLLE
Isoforms
- Isoform 2 of Hematopoietic lineage cell-specific proteinSequence View
10 20 30 40 50 60
MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK
70 80 90 100 110 120
VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF
130 140 150 160 170 180
GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ KDYSRGFGGR YGVEKDKWDK AALGYDYKGE
190 200 210 220 230 240
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGTRGLKA
250 260 270 280 290 300
KFESMAEEKR KREEEEKAQQ VARRQQERKA VTKRSPEAPQ PVIAMEEPAV PAPLPKKISS
310 320 330 340 350 360
EAWPPVGTPP SSESEPVRTS REHPVPLLPI RQTLPEDNEE PPALPPRTLE GLQVEEEPVY
370 380 390 400 410 420
EAEPEPEPEP EPEPENDYED VEEMDRHEQE DEPEGDYEEV LEPEDSSFSS ALAGSSGCPA
430 440 450 460 470 480
GAGAGAVALG ISAVAVYDYQ GEGSDELSFD PDDVITDIEM VDEGWWRGRC HGHFGLFPAN
YVKLLE
Protein Neighborhood
Domains & Features
34 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P14317-1-unknown | MWKSVV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P14317-12- | VSVETQ... | 12 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P14317-13- | SVETQG... | 13 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P14317-27-unknown | FVNDIS... | 27 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11214 | |||
P14317-27- | FVNDIS... | 27 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P14317-27- | FVNDIS... | 27 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P14317-27- | FVNDIS... | 27 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P14317-27- | FVNDIS... | 27 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P14317-38-unknown | WGAKTI... | 38 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P14317-38- | WGAKTI... | 38 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-59- | NKVSEE... | 59 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-94-unknown | MDKSAV... | 94 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P14317-94- | MDKSAV... | 94 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-94- | MDKSAV... | 94 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P14317-94- | MDKSAV... | 94 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
P14317-97- | SAVGHE... | 97 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P14317-97- | SAVGHE... | 97 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P14317-116-unknown | AAKGFG... | 116 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1657 | |||
P14317-119- | GFGGKY... | 119 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-119- | GFGGKY... | 119 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P14317-119- | GFGGKY... | 119 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P14317-166- | DKWDKA... | 166 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-189- | DYAKGF... | 189 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-190-unknown | YAKGFG... | 190 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1658 | |||
P14317-193-unknown | GFGGQY... | 193 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P14317-193- | GFGGQY... | 193 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-193- | GFGGQY... | 193 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P14317-193- | GFGGQY... | 193 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P14317-193- | GFGGQY... | 193 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P14317-193- | GFGGQY... | 193 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-193- | GFGGQY... | 193 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
P14317-203- | DRVDKS... | 203 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-205- | VDKSAV... | 205 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-205- | VDKSAV... | 205 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P14317-208- | SAVGFN... | 208 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-208- | SAVGFN... | 208 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P14317-209-unknown | AVGFNE... | 209 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
P14317-209- | AVGFNE... | 209 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P14317-210- | VGFNEM... | 210 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-211-unknown | GFNEME... | 211 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P14317-211- | GFNEME... | 211 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P14317-211- | GFNEME... | 211 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P14317-211- | GFNEME... | 211 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-211- | GFNEME... | 211 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
P14317-211- | GFNEME... | 211 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P14317-212- | FNEMEA... | 212 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-212- | FNEMEA... | 212 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P14317-215- | MEAPTT... | 215 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P14317-215- | MEAPTT... | 215 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-215- | MEAPTT... | 215 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P14317-240- | AKFESM... | 240 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-240- | AKFESM... | 240 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P14317-275- | SPEAPQ... | 275 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-282- | VIAMEE... | 282 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P14317-284- | AMEEPA... | 284 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P14317-297- | KISSEA... | 297 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P14317-297- | KISSEA... | 297 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P14317-302- | AWPPVG... | 302 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...DTDPDF | 26 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11214 | |||
...SSQTDA | 115 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1657 | |||
...ESQRDY | 189 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1658 | |||
...VKLLE | 486 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 26 | DPDF.|.FVND | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
CASP3_HUMAN | 115 | QTDA.|.AAKG | inferred from experiment | unknown | MEROPS | Merops CASP3_HUMAN -> HCLS1_HUMAN @115 | ||
CASP3_HUMAN | 189 | QRDY.|.YAKG | inferred from experiment | unknown | MEROPS | Merops CASP3_HUMAN -> HCLS1_HUMAN @189 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|