P14868: Aspartate--tRNA ligase, cytoplasmic

General Information

Protein names	- Aspartate--tRNA ligase, cytoplasmic - 6.1.1.12 {ECO:0000250\|UniProtKB:P15178} - Aspartyl-tRNA synthetase - AspRS - Cell proliferation-inducing gene 40 protein
Gene names	DARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P14868

7 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPSASASRKS QEKPREIMDA AEDYAKERYG ISSMIQSQEK PDRVLVRVRD LTIQKADEVV
        70         80         90        100        110        120
WVRARVHTSR AKGKQCFLVL RQQQFNVQAL VAVGDHASKQ MVKFAANINK ESIVDVEGVV
       130        140        150        160        170        180
RKVNQKIGSC TQQDVELHVQ KIYVISLAEP RLPLQLDDAV RPEAEGEEEG RATVNQDTRL
       190        200        210        220        230        240
DNRVIDLRTS TSQAVFRLQS GICHLFRETL INKGFVEIQT PKIISAASEG GANVFTVSYF
       250        260        270        280        290        300
KNNAYLAQSP QLYKQMCICA DFEKVFSIGP VFRAEDSNTH RHLTEFVGLD IEMAFNYHYH
       310        320        330        340        350        360
EVMEEIADTM VQIFKGLQER FQTEIQTVNK QFPCEPFKFL EPTLRLEYCE ALAMLREAGV
       370        380        390        400        410        420
EMGDEDDLST PNEKLLGHLV KEKYDTDFYI LDKYPLAVRP FYTMPDPRNP KQSNSYDMFM
       430        440        450        460        470        480
RGEEILSGAQ RIHDPQLLTE RALHHGIDLE KIKAYIDSFR FGAPPHAGGG IGLERVTMLF
       490        500
LGLHNVRQTS MFPRDPKRLT P

Isoforms

- Isoform 2 of Aspartate--tRNA ligase, cytoplasmic

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P14868-1-unknown	MPSASA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14868-18-acetylation	MDAAED...	18	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P14868-18-acetylation	MDAAED...	18	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P14868-34-unknown	MIQSQE...	34		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000389867
P14868-34-unknown	MIQSQE...	34		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000397616
P14868-34-unknown	MIQSQE...	34		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000388801
P14868-101-unknown	MVKFAA...	101		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444192
P14868-132-unknown	QQDVEL...	132		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7341
P14868-159-	AVRPEA...	159			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14868-159-	AVRPEA...	159			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14868-287-unknown	VGLDIE...	287		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000387508

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IGSCTQ	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7341
...AEGEEE	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388801
...HLFRET	208	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397616
...INKGFV	215	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389867
...KRLTP	501	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	131	SCTQ.\|.QQDV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)