P15170: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

General Information

Protein names	- Eukaryotic peptide chain release factor GTP-binding subunit ERF3A - Eukaryotic peptide chain release factor subunit 3a - eRF3a - G1 to S phase transition protein 1 homolog
Gene names	GSPT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P15170

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Eukaryotic peptide chain release factor GTP-binding subunit ERF3A - Isoform 3 of Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Sequence View

        10         20         30         40         50         60
MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP
        70         80         90        100        110        120
KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET
       130        140        150        160        170        180
WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV
       190        200        210        220        230        240
LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK
       250        260        270        280        290        300
LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG
       310        320        330        340        350        360
PIRLPIVDKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE
       370        380        390        400        410        420
NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI
       430        440        450        460        470        480
EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR
       490
DEGKTIAIGK VLKLVPEKD         10         20         30         40         50         60
MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP
        70         80         90        100        110        120
KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET
       130        140        150        160        170        180
WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV
       190        200        210        220        230        240
LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK
       250        260        270        280        290        300
LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG
       310        320        330        340        350        360
PIRLPIVDKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE
       370        380        390        400        410        420
NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI
       430        440        450        460        470        480
EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR
       490
DEGKTIAIGK VLKLVPEKD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P15170-1-unknown	MELSEP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P15170-1-unknown	MELSEP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106202
P15170-40-unknown	GRPPEE...	40		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P15170-40-unknown	GRPPEE...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161614
P15170-40-unknown	GRPPEE...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161613
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P15170-40-	GRPPEE...	40		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P15170-62-	SVVAPP...	62		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P15170-62-	SVVAPP...	62		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P15170-62-	SVVAPP...	62		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P15170-62-	SVVAPP...	62		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P15170-62-	SVVAPP...	62		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P15170-62-	SVVAPP...	62		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P15170-62-unknown	SVVAPP...	62	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168557
P15170-62-unknown	SVVAPP...	62	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168556
P15170-126-unknown	ALDTNQ...	126	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P15170-126-unknown	ALDTNQ...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197344
P15170-126-unknown	ALDTNQ...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197343
P15170-355-unknown	TVAPGE...	355	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11227
P15170-355-unknown	TVAPGE...	355	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153331
P15170-355-unknown	TVAPGE...	355	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153338
P15170-355-	TVAPGE...	355		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DVETDT	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11227
...DVETDT	354	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136755
...DVETDT	354	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136762
...VPEKD	499	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VPEKD	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69738
...VPEKD	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69739

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	354	ETDT.\|.TVAP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)