P16402: Histone H1.3

General Information

Protein names	- Histone H1.3 - Histone H1c - Histone H1s-2
Gene names	HIST1H1D
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P16402

15 N-termini

12 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSETAPLAPT IPAPAEKTPV KKKAKKAGAT AGKRKASGPP VSELITKAVA ASKERSGVSL
        70         80         90        100        110        120
AALKKALAAA GYDVEKNNSR IKLGLKSLVS KGTLVQTKGT GASGSFKLNK KAASGEGKPK
       130        140        150        160        170        180
AKKAGAAKPR KPAGAAKKPK KVAGAATPKK SIKKTPKKVK KPATAAGTKK VAKSAKKVKT
       190        200        210        220
PQPKKAAKSP AKAKAPKPKA AKPKSGKPKV TKAKKAAPKK K

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

15 N-termini - 12 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P16402-2-unknown	MSETAP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16402-2-	SETAPL...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16402-2-	SETAPL...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16402-2-Acetylation	SETAPL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16402-2-Acetylation	SETAPL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P16402-2-Acetylation	SETAPL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P16402-21-unknown	KKKAKK...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13989
P16402-35-unknown	KASGPP...	35		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13990
P16402-45-unknown	ITKAVA...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13991
P16402-46-unknown	TKAVAA...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13992
P16402-49-unknown	VAASKE...	49		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P16402-66-unknown	ALAAAG...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13993
P16402-68-unknown	AAAGYD...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13994
P16402-69-unknown	AAGYDV...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10000
P16402-69-unknown	AAGYDV...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13995
P16402-70-unknown	AGYDVE...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13996
P16402-72-unknown	YDVEKN...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13997
P16402-112-unknown	AASGEG...	112		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10001
P16402-114-unknown	SGEGKP...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13998

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKTPVK	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13989
...TAGKRK	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13990
...PVSELI	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13991
...VSELIT	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13992
...AALKKA	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13993
...LKKALA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13994
...KKALAA	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10000
...KKALAA	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13995
...KALAAA	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13996
...LAAAGY	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13997
...KLNKKA	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10001
...NKKAAS	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13998
...APKKK	221	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	20	TPVK.\|.KKKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	34	GKRK.\|.KASG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	44	SELI.\|.ITKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	45	ELIT.\|.TKAV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	65	LKKA.\|.ALAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	67	KALA.\|.AAAG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	68	ALAA.\|.AAGY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	68	ALAA.\|.AAGY	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	69	LAAA.\|.AGYD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	71	AAGY.\|.YDVE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	111	NKKA.\|.AASG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	113	KAAS.\|.SGEG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)