P18669: Phosphoglycerate mutase 1

General Information

Protein names	- Phosphoglycerate mutase 1 - 5.4.2.11 {ECO:0000269\|PubMed:23653202} - 5.4.2.4 {ECO:0000269\|PubMed:23653202} - BPG-dependent PGAM 1 - Phosphoglycerate mutase isozyme B - PGAM-B
Gene names	PGAM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P18669

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ
        70         80         90        100        110        120
KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD
       130        140        150        160        170        180
VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR
       190        200        210        220        230        240
VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR
       250
KAMEAVAAQG KAKK

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P18669-2-unknown	AAYKLV...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18669-2-acetylation	AAYKLV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P18669-2-acetylation	AAYKLV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P18669-2-acetylation	AAYKLV...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P18669-118-	SYDVPP...	118			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P18669-118-	SYDVPP...	118			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P18669-118-	SYDVPP...	118			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P18669-118-	SYDVPP...	118			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P18669-120-	DVPPPP...	120			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P18669-120-	DVPPPP...	120			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P18669-120-unknown	DVPPPP...	120		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17415

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...WRRSYD	119	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17415
...GKAKK	254	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GKAKK	254		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GKAKK	254		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	119	RSYD.\|.DVPP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)