P18754: Regulator of chromosome condensation

General Information

Protein names	- Regulator of chromosome condensation - Cell cycle regulatory protein - Chromosome condensation protein 1
Gene names	RCC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P18754

9 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSPKRIAKRR SPPADAIPKS KKVKVSHRSH STEPGLVLTL GQGDVGQLGL GENVMERKKP
        70         80         90        100        110        120
ALVSIPEDVV QAEAGGMHTV CLSKSGQVYS FGCNDEGALG RDTSVEGSEM VPGKVELQEK
       130        140        150        160        170        180
VVQVSAGDSH TAALTDDGRV FLWGSFRDNN GVIGLLEPMK KSMVPVQVQL DVPVVKVASG
       190        200        210        220        230        240
NDHLVMLTAD GDLYTLGCGE QGQLGRVPEL FANRGGRQGL ERLLVPKCVM LKSRGSRGHV
       250        260        270        280        290        300
RFQDAFCGAY FTFAISHEGH VYGFGLSNYH QLGTPGTESC FIPQNLTSFK NSTKSWVGFS
       310        320        330        340        350        360
GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPAVSSV ACGASVGYAV
       370        380        390        400        410        420
TKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MMGKQLENRV VLSVSSGGQH TVLLVKDKEQ

S

Isoforms

- Isoform 2 of Regulator of chromosome condensation

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P18754-1-unknown	MSPKRI...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87209
P18754-2-unknown	MSPKRI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18754-2-N,N,N-trimethylserine	SPKRIA...	2	methylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18754-2-N,N,N-trimethylserine	SPKRIA...	2	methylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111345
P18754-45-unknown	VGQLGL...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11306
P18754-45-unknown	VGQLGL...	45		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141023
P18754-74-unknown	AGGMHT...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11308
P18754-74-unknown	AGGMHT...	74		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142638
P18754-162-unknown	SMVPVQ...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168160
P18754-162-	SMVPVQ...	162			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P18754-162-	SMVPVQ...	162			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P18754-162-	SMVPVQ...	162			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P18754-162-	SMVPVQ...	162			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P18754-231-unknown	LKSRGS...	231		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14027
P18754-231-unknown	LKSRGS...	231		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148901
P18754-311-unknown	SEGKAY...	311		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11310
P18754-311-unknown	SEGKAY...	311		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150773

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGQGDV	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11306
...VVQAEA	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11308
...VVQAEA	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125834
...PKCVML	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14027
...PKCVML	230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132280
...TVCMDS	310	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11310
...TVCMDS	310	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134175
...DKEQS	421	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DKEQS	421	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82827

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	44	QGDV.\|.VGQL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	73	QAEA.\|.AGGM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	230	CVML.\|.LKSR	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	310	CMDS.\|.SEGK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)