P19623: Spermidine synthase

General Information

Protein names	- Spermidine synthase - SPDSY - 2.5.1.16 - Putrescine aminopropyltransferase
Gene names	SRM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P19623

4 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEPGPDGPAA SGPAAIREGW FRETCSLWPG QALSLQVEQL LHHRRSRYQD ILVFRSKTYG
        70         80         90        100        110        120
NVLVLDGVIQ CTERDEFSYQ EMIANLPLCS HPNPRKVLII GGGDGGVLRE VVKHPSVESV
       130        140        150        160        170        180
VQCEIDEDVI QVSKKFLPGM AIGYSSSKLT LHVGDGFEFM KQNQDAFDVI ITDSSDPMGP
       190        200        210        220        230        240
AESLFKESYY QLMKTALKED GVLCCQGECQ WLHLDLIKEM RQFCQSLFPV VAYAYCTIPT
       250        260        270        280        290        300
YPSGQIGFML CSKNPSTNFQ EPVQPLTQQQ VAQMQLKYYN SDVHRAAFVL PEFARKALND

VS

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P19623-1-Acetylation	MEPGPD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P19623-1-Acetylation	MEPGPD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P19623-1-Acetylation	MEPGPD...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P19623-1-Acetylation	MEPGPD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P19623-1-Acetylation	MEPGPD...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P19623-7-	GPAASG...	7			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P19623-7-	GPAASG...	7			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P19623-9-	AASGPA...	9			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P19623-9-	AASGPA...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P19623-9-	AASGPA...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P19623-9-	AASGPA...	9			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P19623-9-	AASGPA...	9			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P19623-99-unknown	IIGGGD...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3678

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRKVLI	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3678
...AIGYSS	145	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468760
...VLCCQG	206	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467669
...LNDVS	302	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	98	KVLI.\|.IIGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)