P20042: Eukaryotic translation initiation factor 2 subunit 2

General Information

Protein names	- Eukaryotic translation initiation factor 2 subunit 2 - Eukaryotic translation initiation factor 2 subunit beta - eIF-2-beta
Gene names	EIF2S2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20042

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGDEMIFDP TMSKKKKKKK KPFMLDEEGD TQTEETQPSE TKEVEPEPTE DKDLEADEED
        70         80         90        100        110        120
TRKKDASDDL DDLNFFNQKK KKKKTKKIFD IDEAEEGVKD LKIESDVQEP TEPEDDLDIM
       130        140        150        160        170        180
LGNKKKKKKN VKFPDEDEIL EKDEALEDED NKKDDGISFS NQTGPAWAGS ERDYTYEELL
       190        200        210        220        230        240
NRVFNIMREK NPDMVAGEKR KFVMKPPQVV RVGTKKTSFV NFTDICKLLH RQPKHLLAFL
       250        260        270        280        290        300
LAELGTSGSI DGNNQLVIKG RFQQKQIENV LRRYIKEYVT CHTCRSPDTI LQKDTRLYFL
       310        320        330
QCETCHSRCS VASIKTGFQA VTGKRAQLRA KAN

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P20042-2-unknown	MSGDEM...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P20042-2-Acetylation	SGDEMI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P20042-2-Acetylation	SGDEMI...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P20042-6-	MIFDPT...	6			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P20042-24-	MLDEEG...	24			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P20042-24-	MLDEEG...	24			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P20042-88-	IFDIDE...	88			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P20042-88-	IFDIDE...	88			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P20042-88-	IFDIDE...	88			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P20042-88-	IFDIDE...	88			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P20042-246-unknown	TSGSID...	246		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7357

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LAELGT	245	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7357
	...RAKAN	333	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	245	ELGT.\|.TSGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)