P22090: 40S ribosomal protein S4, Y isoform 1

General Information

Protein names	- 40S ribosomal protein S4, Y isoform 1 - Small ribosomal subunit protein eS4 {ECO:0000303\|PubMed:24524803}
Gene names	RPS4Y1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22090

5 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE
        70         80         90        100        110        120
VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITVEEAK
       130        140        150        160        170        180
YKLCKVRKIT VGVKGIPHLV THDARTIRYP DPVIKVNDTV QIDLGTGKII NFIKFDTGNL
       190        200        210        220        230        240
CMVIGGANLG RVGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR
       250        260
GKGIRLTVAE ERDKRLATKQ SSG

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P22090-2-unknown	ARGPKK...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22090-2-unknown	ARGPKK...	2	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P22090-22-unknown	KLTGVF...	22	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11339
P22090-57-unknown	TGDEVK...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14031
P22090-118-unknown	EAKYKL...	118	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11340
P22090-135-	GIPHLV...	135		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P22090-135-	GIPHLV...	135		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P22090-135-	GIPHLV...	135		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HWMLDK	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11339
...LKYALT	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14031
...RITVEE	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11340
...AEERDK	253	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415317
...KQSSG	263	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	21	MLDK.\|.KLTG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	56	YALT.\|.TGDE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	117	TVEE.\|.EAKY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)