P25205: DNA replication licensing factor MCM3

General Information

Protein names	- DNA replication licensing factor MCM3 - 3.6.4.12 - DNA polymerase alpha holoenzyme-associated protein P1 - P1-MCM3 - RLF subunit beta - p102
Gene names	MCM3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P25205

10 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGTVVLDDV ELREAQRDYL DFLDDEEDQG IYQSKVRELI SDNQYRLIVN VNDLRRKNEK
        70         80         90        100        110        120
RANRLLNNAF EELVAFQRAL KDFVASIDAT YAKQYEEFYV GLEGSFGSKH VSPRTLTSCF
       130        140        150        160        170        180
LSCVVCVEGI VTKCSLVRPK VVRSVHYCPA TKKTIERRYS DLTTLVAFPS SSVYPTKDEE
       190        200        210        220        230        240
NNPLETEYGL SVYKDHQTIT IQEMPEKAPA GQLPRSVDVI LDDDLVDKAK PGDRVQVVGT
       250        260        270        280        290        300
YRCLPGKKGG YTSGTFRTVL IACNVKQMSK DAQPSFSAED IAKIKKFSKT RSKDIFDQLA
       310        320        330        340        350        360
KSLAPSIHGH DYVKKAILCL LLGGVERDLE NGSHIRGDIN ILLIGDPSVA KSQLLRYVLC
       370        380        390        400        410        420
TAPRAIPTTG RGSSGVGLTA AVTTDQETGE RRLEAGAMVL ADRGVVCIDE FDKMSDMDRT
       430        440        450        460        470        480
AIHEVMEQGR VTIAKAGIHA RLNARCSVLA AANPVYGRYD QYKTPMENIG LQDSLLSRFD
       490        500        510        520        530        540
LLFIMLDQMD PEQDREISDH VLRMHRYRAP GEQDGDAMPL GSAVDILATD DPNFSQEDQQ
       550        560        570        580        590        600
DTQIYEKHDN LLHGTKKKKE KMVSAAFMKK YIHVAKIIKP VLTQESATYI AEEYSRLRSQ
       610        620        630        640        650        660
DSMSSDTART SPVTARTLET LIRLATAHAK ARMSKTVDLQ DAEEAVELVQ YAYFKKVLEK
       670        680        690        700        710        720
EKKRKKRSED ESETEDEEEK SQEDQEQKRK RRKTRQPDAK DGDSYDPYDF SDTEEEMPQV
       730        740        750        760        770        780
HTPKTADSQE TKESQKVELS ESRLKAFKVA LLDVFREAHA QSIGMNRLTE SINRDSEEPF
       790        800
SSVEIQAALS KMQDDNQVMV SEGIIFLI

Isoforms

- Isoform 2 of DNA replication licensing factor MCM3

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P25205-2-unknown	MAGTVV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25205-2-	AGTVVL...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25205-2-Acetylation	AGTVVL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25205-2-Acetylation	AGTVVL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P25205-2-Acetylation	AGTVVL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P25205-2-Acetylation	AGTVVL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P25205-22-unknown	FLDDEE...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11354
P25205-22-	FLDDEE...	22			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P25205-172-	SVYPTK...	172			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P25205-302-	SLAPSI...	302			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P25205-506-unknown	RYRAPG...	506		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407651
P25205-702-	GDSYDP...	702			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25205-702-	GDSYDP...	702			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P25205-702-	GDSYDP...	702			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P25205-704-	SYDPYD...	704			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25205-704-	SYDPYD...	704			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P25205-704-	SYDPYD...	704			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P25205-704-	SYDPYD...	704			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...RDYLDF	21	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11354
	...IIFLI	808	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	21	YLDF.\|.FLDD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)