P25440: Bromodomain-containing protein 2

General Information

Protein names	- Bromodomain-containing protein 2 - O27.1.1 - Really interesting new gene 3 protein
Gene names	BRD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P25440

11 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Bromodomain-containing protein 2 - Isoform 3 of Bromodomain-containing protein 2 - Isoform 4 of Bromodomain-containing protein 2

Sequence View

        10         20         30         40         50         60
MLQNVTPHNK LPGEGNAGLL GLGPEAAAPG KRIRKPSLLY EGFESPTMAS VPALQLTPAN
        70         80         90        100        110        120
PPPPEVSNPK KPGRVTNQLQ YLHKVVMKAL WKHQFAWPFR QPVDAVKLGL PDYHKIIKQP
       130        140        150        160        170        180
MDMGTIKRRL ENNYYWAASE CMQDFNTMFT NCYIYNKPTD DIVLMAQTLE KIFLQKVASM
       190        200        210        220        230        240
PQEEQELVVT IPKNSHKKGA KLAALQGSVT SAHQVPAVSS VSHTALYTPP PEIPTTVLNI
       250        260        270        280        290        300
PHPSVISSPL LKSLHSAGPP LLAVTAAPPA QPLAKKKGVK RKADTTTPTP TAILAPGSPA
       310        320        330        340        350        360
SPPGSLEPKA ARLPPMRRES GRPIKPPRKD LPDSQQQHQS SKKGKLSEQL KHCNGILKEL
       370        380        390        400        410        420
LSKKHAAYAW PFYKPVDASA LGLHDYHDII KHPMDLSTVK RKMENRDYRD AQEFAADVRL
       430        440        450        460        470        480
MFSNCYKYNP PDHDVVAMAR KLQDVFEFRY AKMPDEPLEP GPLPVSTAMP PGLAKSSSES
       490        500        510        520        530        540
SSEESSSESS SEEEEEEDEE DEEEEESESS DSEEERAHRL AELQEQLRAV HEQLAALSQG
       550        560        570        580        590        600
PISKPKRKRE KKEKKKKRKA EKHRGRAGAD EDDKGPRAPR PPQPKKSKKA SGSGGGSAAL
       610        620        630        640        650        660
GPSGFGPSGG SGTKLPKKAT KTAPPALPTG YDSEEEEESR PMSYDEKRQL SLDINKLPGE
       670        680        690        700        710        720
KLGRVVHIIQ AREPSLRDSN PEEIEIDFET LKPSTLRELE RYVLSCLRKK PRKPYTIKKP
       730        740        750        760        770        780
VGKTKEELAL EKKRELEKRL QDVSGQLNST KKPPKKANEK TESSSAQQVA VSRLSASSSS
       790        800
SDSSSSSSSS SSSDTSDSDS G         10         20         30         40         50         60
MLQNVTPHNK LPGEGNAGLL GLGPEAAAPG KRIRKPSLLY EGFESPTMAS VPALQLTPAN
        70         80         90        100        110        120
PPPPEVSNPK KPGRVTNQLQ YLHKVVMKAL WKHQFAWPFR QPVDAVKLGL PDYHKIIKQP
       130        140        150        160        170        180
MDMGTIKRRL ENNYYWAASE CMQDFNTMFT NCYIYNKPTD DIVLMAQTLE KIFLQKVASM
       190        200        210        220        230        240
PQEEQELVVT IPKNSHKKGA KLAALQGSVT SAHQVPAVSS VSHTALYTPP PEIPTTVLNI
       250        260        270        280        290        300
PHPSVISSPL LKSLHSAGPP LLAVTAAPPA QPLAKKKGVK RKADTTTPTP TAILAPGSPA
       310        320        330        340        350        360
SPPGSLEPKA ARLPPMRRES GRPIKPPRKD LPDSQQQHQS SKKGKLSEQL KHCNGILKEL
       370        380        390        400        410        420
LSKKHAAYAW PFYKPVDASA LGLHDYHDII KHPMDLSTVK RKMENRDYRD AQEFAADVRL
       430        440        450        460        470        480
MFSNCYKYNP PDHDVVAMAR KLQDVFEFRY AKMPDEPLEP GPLPVSTAMP PGLAKSSSES
       490        500        510        520        530        540
SSEESSSESS SEEEEEEDEE DEEEEESESS DSEEERAHRL AELQEQLRAV HEQLAALSQG
       550        560        570        580        590        600
PISKPKRKRE KKEKKKKRKA EKHRGRAGAD EDDKGPRAPR PPQPKKSKKA SGSGGGSAAL
       610        620        630        640        650        660
GPSGFGPSGG SGTKLPKKAT KTAPPALPTG YDSEEEEESR PMSYDEKRQL SLDINKLPGE
       670        680        690        700        710        720
KLGRVVHIIQ AREPSLRDSN PEEIEIDFET LKPSTLRELE RYVLSCLRKK PRKPYTIKKP
       730        740        750        760        770        780
VGKTKEELAL EKKRELEKRL QDVSGQLNST KKPPKKANEK TESSSAQQVA VSRLSASSSS
       790        800
SDSSSSSSSS SSSDTSDSDS G         10         20         30         40         50         60
MLQNVTPHNK LPGEGNAGLL GLGPEAAAPG KRIRKPSLLY EGFESPTMAS VPALQLTPAN
        70         80         90        100        110        120
PPPPEVSNPK KPGRVTNQLQ YLHKVVMKAL WKHQFAWPFR QPVDAVKLGL PDYHKIIKQP
       130        140        150        160        170        180
MDMGTIKRRL ENNYYWAASE CMQDFNTMFT NCYIYNKPTD DIVLMAQTLE KIFLQKVASM
       190        200        210        220        230        240
PQEEQELVVT IPKNSHKKGA KLAALQGSVT SAHQVPAVSS VSHTALYTPP PEIPTTVLNI
       250        260        270        280        290        300
PHPSVISSPL LKSLHSAGPP LLAVTAAPPA QPLAKKKGVK RKADTTTPTP TAILAPGSPA
       310        320        330        340        350        360
SPPGSLEPKA ARLPPMRRES GRPIKPPRKD LPDSQQQHQS SKKGKLSEQL KHCNGILKEL
       370        380        390        400        410        420
LSKKHAAYAW PFYKPVDASA LGLHDYHDII KHPMDLSTVK RKMENRDYRD AQEFAADVRL
       430        440        450        460        470        480
MFSNCYKYNP PDHDVVAMAR KLQDVFEFRY AKMPDEPLEP GPLPVSTAMP PGLAKSSSES
       490        500        510        520        530        540
SSEESSSESS SEEEEEEDEE DEEEEESESS DSEEERAHRL AELQEQLRAV HEQLAALSQG
       550        560        570        580        590        600
PISKPKRKRE KKEKKKKRKA EKHRGRAGAD EDDKGPRAPR PPQPKKSKKA SGSGGGSAAL
       610        620        630        640        650        660
GPSGFGPSGG SGTKLPKKAT KTAPPALPTG YDSEEEEESR PMSYDEKRQL SLDINKLPGE
       670        680        690        700        710        720
KLGRVVHIIQ AREPSLRDSN PEEIEIDFET LKPSTLRELE RYVLSCLRKK PRKPYTIKKP
       730        740        750        760        770        780
VGKTKEELAL EKKRELEKRL QDVSGQLNST KKPPKKANEK TESSSAQQVA VSRLSASSSS
       790        800
SDSSSSSSSS SSSDTSDSDS G

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P25440-1-	MLQNVT...	1			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P25440-1-	MLQNVT...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25440-1-	MLQNVT...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P25440-1-Acetylation	MLQNVT...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25440-1-Acetylation	MLQNVT...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106087
P25440-1-unknown	MLQNVT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68603
P25440-48-unknown	MASVPA...	48		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000405634
P25440-48-unknown	MASVPA...	48		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447519
P25440-48-unknown	MASVPA...	48		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409145
P25440-48-unknown	MASVPA...	48		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448429
P25440-48-unknown	MASVPA...	48		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446894
P25440-48-unknown	MASVPA...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196069
P25440-121-unknown	MDMGTI...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450326
P25440-121-unknown	MDMGTI...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000447210
P25440-121-unknown	MDMGTI...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413495
P25440-121-unknown	MDMGTI...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449979
P25440-121-unknown	MDMGTI...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448867
P25440-121-unknown	MDMGTI...	121		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197244
P25440-220-unknown	SVSHTA...	220		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167800
P25440-220-	SVSHTA...	220			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P25440-253-unknown	SLHSAG...	253		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169855
P25440-253-	SLHSAG...	253			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P25440-537-unknown	LSQGPI...	537		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3727
P25440-537-unknown	LSQGPI...	537		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153841
P25440-688-unknown	FETLKP...	688		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11355
P25440-688-unknown	FETLKP...	688		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156089

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PTAILA	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405050
...PTAILA	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411074
...PTAILA	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411195
...PTAILA	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416399
...PTAILA	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391758
...EQLAAL	536	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3727
...EQLAAL	536	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137263
...KREKKE	552	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475691
...EIEIDF	687	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11355
...EIEIDF	687	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139552
...DSDSG	801	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DSDSG	801	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64221

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	536	LAAL.\|.LSQG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	687	EIDF.\|.FETL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)