P28074: Proteasome subunit beta type-5

General Information

Protein names	- Proteasome subunit beta type-5 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - Macropain epsilon chain - Multicatalytic endopeptidase complex epsilon chain - Proteasome chain 6 - Proteasome epsilon chain - Proteasome subunit MB1 - Proteasome subunit X
Gene names	PSMB5
Organism	Homo sapiens
Protease Family
Protease ID	T01.P01
Chromosome location
UniProt ID	P28074

6 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Proteasome subunit beta type-5 - Isoform 3 of Proteasome subunit beta type-5

Sequence View

        10         20         30         40         50         60
MALASVLERP LPVNQRGFFG LGGRADLLDL GPGSLSDGLS LAAPGWGVPE EPGIEMLHGT
        70         80         90        100        110        120
TTLAFKFRHG VIVAADSRAT AGAYIASQTV KKVIEINPYL LGTMAGGAAD CSFWERLLAR
       130        140        150        160        170        180
QCRIYELRNK ERISVAAASK LLANMVYQYK GMGLSMGTMI CGWDKRGPGL YYVDSEGNRI
       190        200        210        220        230        240
SGATFSVGSG SVYAYGVMDR GYSYDLEVEQ AYDLARRAIY QATYRDAYSG GAVNLYHVRE
       250        260
DGWIRVSSDN VADLHEKYSG STP         10         20         30         40         50         60
MALASVLERP LPVNQRGFFG LGGRADLLDL GPGSLSDGLS LAAPGWGVPE EPGIEMLHGT
        70         80         90        100        110        120
TTLAFKFRHG VIVAADSRAT AGAYIASQTV KKVIEINPYL LGTMAGGAAD CSFWERLLAR
       130        140        150        160        170        180
QCRIYELRNK ERISVAAASK LLANMVYQYK GMGLSMGTMI CGWDKRGPGL YYVDSEGNRI
       190        200        210        220        230        240
SGATFSVGSG SVYAYGVMDR GYSYDLEVEQ AYDLARRAIY QATYRDAYSG GAVNLYHVRE
       250        260
DGWIRVSSDN VADLHEKYSG STP

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P28074-1-unknown	MALASV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86356
P28074-2-acetylation	ALASVL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P28074-2-acetylation	ALASVL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P28074-2-acetylation	ALASVL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162855
P28074-60-	TTTLAF...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P28074-60-	TTTLAF...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P28074-60-	TTTLAF...	60			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P28074-60-unknown	TTTLAF...	60		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P28074-60-unknown	TTTLAF...	60		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115722
P28074-104-unknown	MAGGAA...	104		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86357
P28074-104-unknown	MAGGAA...	104		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100756
P28074-106-unknown	GGAADC...	106		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7398
P28074-106-unknown	GGAADC...	106		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142715
P28074-106-unknown	GGAADC...	106		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197074

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LGTMAG	105	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7398
...LGTMAG	105	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125916
...SGSTP	263	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SGSTP	263	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81975
...SGSTP	263		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SGSTP	263		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	105	TMAG.\|.GGAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)