P29083: General transcription factor IIE subunit 1

General Information

Protein names	- General transcription factor IIE subunit 1 - General transcription factor IIE 56 kDa subunit - Transcription initiation factor IIE subunit alpha - TFIIE-alpha
Gene names	GTF2E1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P29083

7 N-termini

7 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN SCVKEEDMLE LLKFDRKQLR
        70         80         90        100        110        120
SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD
       130        140        150        160        170        180
STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCHTE VEEDESAMPK KDARTLLARF
       190        200        210        220        230        240
NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDH AATTAGAASL AGGHHREAWA
       250        260        270        280        290        300
TKGPSYEDLY TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY GSEDMKEGGI
       310        320        330        340        350        360
DMDAFQEREE GHAGPDDNEE VMRALLIHEK KTSSAMAGSV GAAAPVTAAN GSDSESETSE
       370        380        390        400        410        420
SDDDSPPRPA AVAVHKREED EEEDDEFEEV ADDPIVMVAG RPFSYSEVSQ RPELVAQMTP
       430
EEKEAYIAMG QRMFEDLFE

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P29083-2-unknown	MADPDV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P29083-2-Acetylation	ADPDVL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P29083-2-Acetylation	ADPDVL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P29083-2-Acetylation	ADPDVL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P29083-6-unknown	VLTEVP...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11411
P29083-168-unknown	MPKKDA...	168		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418808
P29083-298-	GGIDMD...	298			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P29083-298-	GGIDMD...	298			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P29083-298-	GGIDMD...	298			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P29083-298-	GGIDMD...	298			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P29083-304-unknown	AFQERE...	304		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11412
P29083-304-	AFQERE...	304			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P29083-304-	AFQERE...	304			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P29083-304-	AFQERE...	304			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MADPDV	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11411
...EEDMLE	49	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000417342
...ERDSTN	122	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000417077
...SEDMKE	296	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418808
...GIDMDA	303	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11412
...EDLFE	439	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EDLFE	439		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EDLFE	439		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	5	DPDV.\|.VLTE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	303	DMDA.\|.AFQE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)