P30260: Cell division cycle protein 27 homolog

General Information

Protein names	- Cell division cycle protein 27 homolog - Anaphase-promoting complex subunit 3 - APC3 - CDC27 homolog - CDC27Hs - H-NUC
Gene names	CDC27
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30260

7 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTVLQEPVQA AIWQALNHYA YRDAVFLAER LYAEVHSEEA LFLLATCYYR SGKAYKAYRL
        70         80         90        100        110        120
LKGHSCTTPQ CKYLLAKCCV DLSKLAEGEQ ILSGGVFNKQ KSHDDIVTEF GDSACFTLSL
       130        140        150        160        170        180
LGHVYCKTDR LAKGSECYQK SLSLNPFLWS PFESLCEIGE KPDPDQTFKF TSLQNFSNCL
       190        200        210        220        230        240
PNSCTTQVPN HSLSHRQPET VLTETPQDTI ELNRLNLESS NSKYSLNTDS SVSYIDSAVI
       250        260        270        280        290        300
SPDTVPLGTG TSILSKQVQN KPKTGRSLLG GPAALSPLTP SFGILPLETP SPGDGSYLQN
       310        320        330        340        350        360
YTNTPPVIDV PSTGAPSKKS VARIGQTGTK SVFSQSGNSR EVTPILAQTQ SSGPQTSTTP
       370        380        390        400        410        420
QVLSPTITSP PNALPRRSSR LFTSDSSTTK ENSKKLKMKF PPKIPNRKTK SKTNKGGITQ
       430        440        450        460        470        480
PNINDSLEIT KLDSSIISEG KISTITPQIQ AFNLQKAAAE GLMSLLREMG KGYLALCSYN
       490        500        510        520        530        540
CKEAINILSH LPSHHYNTGW VLCQIGRAYF ELSEYMQAER IFSEVRRIEN YRVEGMEIYS
       550        560        570        580        590        600
TTLWHLQKDV ALSVLSKDLT DMDKNSPEAW CAAGNCFSLQ REHDIAIKFF QRAIQVDPNY
       610        620        630        640        650        660
AYAYTLLGHE FVLTEELDKA LACFRNAIRV NPRHYNAWYG LGMIYYKQEK FSLAEMHFQK
       670        680        690        700        710        720
ALDINPQSSV LLCHIGVVQH ALKKSEKALD TLNKAIVIDP KNPLCKFHRA SVLFANEKYK
       730        740        750        760        770        780
SALQELEELK QIVPKESLVY FLIGKVYKKL GQTHLALMNF SWAMDLDPKG ANNQIKEAID
       790        800        810        820
KRYLPDDEEP ITQEEQIMGT DESQESSMTD ADDTQLHAAE SDEF

Isoforms

- Isoform 2 of Cell division cycle protein 27 homolog

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30260-1-unknown	MTVLQE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30260-1-unknown	MTVLQE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70043
P30260-227-unknown	NTDSSV...	227	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14080
P30260-227-unknown	NTDSSV...	227	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147611
P30260-237-	SAVISP...	237		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P30260-237-	SAVISP...	237		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P30260-237-	SAVISP...	237		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P30260-237-	SAVISP...	237		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P30260-237-unknown	SAVISP...	237	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168104
P30260-244-unknown	TVPLGT...	244	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11434
P30260-244-unknown	TVPLGT...	244	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148252
P30260-244-	TVPLGT...	244		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P30260-802-unknown	ESQESS...	802	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11436
P30260-802-unknown	ESQESS...	802	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156520

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SKYSLN	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14080
...SKYSLN	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130963
...VISPDT	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11434
...VISPDT	243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131618
...IMGTDE	801	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11436
...IMGTDE	801	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140004
...ESDEF	824	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ESDEF	824	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65661

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	226	YSLN.\|.NTDS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	243	SPDT.\|.TVPL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	801	GTDE.\|.ESQE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)