P30740: Leukocyte elastase inhibitor

General Information

Protein names	- Leukocyte elastase inhibitor - LEI - Monocyte/neutrophil elastase inhibitor - EI - M/NEI - Peptidase inhibitor 2 - PI-2 - Serpin B1
Gene names	SERPINB1
Organism	Homo sapiens
Protease Family
Protease ID	I04.006
Chromosome location
UniProt ID	P30740

6 N-termini

3 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEQLSSANTR FALDLFLALS ENNPAGNIFI SPFSISSAMA MVFLGTRGNT AAQLSKTFHF
        70         80         90        100        110        120
NTVEEVHSRF QSLNADINKR GASYILKLAN RLYGEKTYNF LPEFLVSTQK TYGADLASVD
       130        140        150        160        170        180
FQHASEDARK TINQWVKGQT EGKIPELLAS GMVDNMTKLV LVNAIYFKGN WKDKFMKEAT
       190        200        210        220        230        240
TNAPFRLNKK DRKTVKMMYQ KKKFAYGYIE DLKCRVLELP YQGEELSMVI LLPDDIEDES
       250        260        270        280        290        300
TGLKKIEEQL TLEKLHEWTK PENLDFIEVN VSLPRFKLEE SYTLNSDLAR LGVQDLFNSS
       310        320        330        340        350        360
KADLSGMSGA RDIFISKIVH KSFVEVNEEG TEAAAATAGI ATFCMLMPEE NFTADHPFLF
       370
FIRHNSSGSI LFLGRFSSP

Isoforms

- Isoform 2 of Leukocyte elastase inhibitor

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30740-1-Acetylation	MEQLSS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30740-1-Acetylation	MEQLSS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P30740-1-Acetylation	MEQLSS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P30740-1-Acetylation	MEQLSS...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30740-152-unknown	MVDNMT...	152		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444543
P30740-298-	NSSKAD...	298			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P30740-344-unknown	CMLMPE...	344		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8450
P30740-344-unknown	CMLMPE...	344		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8430
P30740-344-unknown	CMLMPE...	344		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4857
P30740-345-unknown	MLMPEE...	345		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16220
P30740-345-unknown	MLMPEE...	345		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27790
P30740-345-unknown	MLMPEE...	345		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8347
P30740-345-unknown	MLMPEE...	345		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9420
P30740-345-	MLMPEE...	345			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GIATFC	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8450
...GIATFC	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8430
...GIATFC	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4857
...IATFCM	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16220
...IATFCM	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27790
...IATFCM	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8347
...IATFCM	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9420
...RFSSP	379	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CTRB2_HUMAN	343	ATFC.\|.CMLM	inferred from experiment	unknown	MEROPS	Remold-O'Donnell E	Cooley J et al.:The serpin MNEI inhibits elasta... (S01.133)	11747453,
CMA1_HUMAN	343	ATFC.\|.CMLM	inferred from experiment	unknown	MEROPS	Remold-O'Donnell E	Cooley J et al.:The serpin MNEI inhibits elasta... (S01.133)	11747453,
CATG_HUMAN	343	ATFC.\|.CMLM	inferred from experiment	unknown	MEROPS	Remold-O'Donnell E	Cooley J et al.:The serpin MNEI inhibits elasta... (S01.133)	11747453,
KLK3_HUMAN	344	TFCM.\|.MLMP	inferred from experiment	unknown	MEROPS	Remold-O'Donnell E	Cooley J et al.:The serpin MNEI inhibits elasta... (S01.133)	11747453,
PRTN3_HUMAN	344	TFCM.\|.MLMP	inferred from experiment	unknown	MEROPS	Remold-O'Donnell E	Cooley J et al.:The serpin MNEI inhibits elasta... (S01.133)	11747453,
CELA1_HUMAN	344	TFCM.\|.MLMP	inferred from experiment	unknown	MEROPS	Remold-O'Donnell E	Cooley J et al.:The serpin MNEI inhibits elasta... (S01.133)	11747453,
ELNE_HUMAN	344	TFCM.\|.MLMP	inferred from experiment	unknown	MEROPS	Remold-O'Donnell E	Cooley J et al.:The serpin MNEI inhibits elasta... (S01.133)	11747453,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)