P33992: DNA replication licensing factor MCM5 {ECO:0000303|Ref.3}

General Information

Protein names	- DNA replication licensing factor MCM5 {ECO:0000303\|Ref.3} - 3.6.4.12 - CDC46 homolog {ECO:0000250\|UniProtKB:P49718} - P1-CDC46 {ECO:0000303\|PubMed:8265339}
Gene names	MCM5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P33992

8 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGFDDPGIF YSDSFGGDAQ ADEGQARKSQ LQRRFKEFLR QYRVGTDRTG FTFKYRDELK
        70         80         90        100        110        120
RHYNLGEYWI EVEMEDLASF DEDLADYLYK QPAEHLQLLE EAAKEVADEV TRPRPSGEEV
       130        140        150        160        170        180
LQDIQVMLKS DASPSSIRSL KSDMMSHLVK IPGIIIAASA VRAKATRISI QCRSCRNTLT
       190        200        210        220        230        240
NIAMRPGLEG YALPRKCNTD QAGRPKCPLD PYFIMPDKCK CVDFQTLKLQ ELPDAVPHGE
       250        260        270        280        290        300
MPRHMQLYCD RYLCDKVVPG NRVTIMGIYS IKKFGLTTSR GRDRVGVGIR SSYIRVLGIQ
       310        320        330        340        350        360
VDTDGSGRSF AGAVSPQEEE EFRRLAALPN VYEVISKSIA PSIFGGTDMK KAIACLLFGG
       370        380        390        400        410        420
SRKRLPDGLT RRGDINLLML GDPGTAKSQL LKFVEKCSPI GVYTSGKGSS AAGLTASVMR
       430        440        450        460        470        480
DPSSRNFIME GGAMVLADGG VVCIDEFDKM REDDRVAIHE AMEQQTISIA KAGITTTLNS
       490        500        510        520        530        540
RCSVLAAANS VFGRWDETKG EDNIDFMPTI LSRFDMIFIV KDEHNEERDV MLAKHVITLH
       550        560        570        580        590        600
VSALTQTQAV EGEIDLAKLK KFIAYCRVKC GPRLSAEAAE KLKNRYIIMR SGARQHERDS
       610        620        630        640        650        660
DRRSSIPITV RQLEAIVRIA EALSKMKLQP FATEADVEEA LRLFQVSTLD AALSGTLSGV
       670        680        690        700        710        720
EGFTSQEDQE MLSRIEKQLK RRFAIGSQVS EHSIIKDFTK QKYPEHAIHK VLQLMLRRGE
       730
IQHRMQRKVL YRLK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P33992-2-unknown	MSGFDD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P33992-2-Acetylation	SGFDDP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P33992-2-Acetylation	SGFDDP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P33992-2-Acetylation	SGFDDP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P33992-14-	SFGGDA...	14			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P33992-14-unknown	SFGGDA...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11449
P33992-14-unknown	SFGGDA...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1218
P33992-14-unknown	SFGGDA...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1784
P33992-14-unknown	SFGGDA...	14			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P33992-14-unknown	SFGGDA...	14			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P33992-144-unknown	MMSHLV...	144		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408705
P33992-235-	AVPHGE...	235			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P33992-309-	SFAGAV...	309			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P33992-309-	SFAGAV...	309			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P33992-309-	SFAGAV...	309			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P33992-439-unknown	GGVVCI...	439		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11450

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IFYSDS	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11449
...IFYSDS	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1218
...IFYSDS	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1784
...PRKCNT	198	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393977
...IRSSYI	293	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408705
...MVLADG	438	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11450
...LYRLK	734	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	13	YSDS.\|.SFGG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP1_HUMAN	13	YSDS.\|.SFGG	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CASP3_HUMAN	13	YSDS.\|.SFGG	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> MCM5_HUMAN @13
GRAB_HUMAN	438	LADG.\|.GGVV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)