P36543: V-type proton ATPase subunit E 1

General Information

Protein names	- V-type proton ATPase subunit E 1 - V-ATPase subunit E 1 - V-ATPase 31 kDa subunit - p31 - Vacuolar proton pump subunit E 1
Gene names	ATP6V1E1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P36543

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of V-type proton ATPase subunit E 1 - Isoform 3 of V-type proton ATPase subunit E 1

Sequence View

        10         20         30         40         50         60
MALSDADVQK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR LKIMEYYEKK
        70         80         90        100        110        120
EKQIEQQKKI QMSNLMNQAR LKVLRARDDL ITDLLNEAKQ RLSKVVKDTT RYQVLLDGLV
       130        140        150        160        170        180
LQGLYQLLEP RMIVRCRKQD FPLVKAAVQK AIPMYKIATK NDVDVQIDQE SYLPEDIAGG
       190        200        210        220
VEIYNGDRKI KVSNTLESRL DLIAQQMMPE VRGALFGANA NRKFLD         10         20         30         40         50         60
MALSDADVQK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR LKIMEYYEKK
        70         80         90        100        110        120
EKQIEQQKKI QMSNLMNQAR LKVLRARDDL ITDLLNEAKQ RLSKVVKDTT RYQVLLDGLV
       130        140        150        160        170        180
LQGLYQLLEP RMIVRCRKQD FPLVKAAVQK AIPMYKIATK NDVDVQIDQE SYLPEDIAGG
       190        200        210        220
VEIYNGDRKI KVSNTLESRL DLIAQQMMPE VRGALFGANA NRKFLD

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P36543-2-unknown	MALSDA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P36543-1-unknown	MALSDA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94060
P36543-2-Acetylation	ALSDAD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P36543-2-Acetylation	ALSDAD...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P36543-2-Acetylation	ALSDAD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110049
P36543-17-unknown	AFIEQE...	17		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176259
P36543-17-	AFIEQE...	17			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P36543-17-	AFIEQE...	17			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P36543-198-unknown	SRLDLI...	198		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11470
P36543-198-unknown	SRLDLI...	198		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145469
P36543-198-unknown	SRLDLI...	198		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145767

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SNTLES	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11470
...SNTLES	197	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128764
...SNTLES	197	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129064
...RKFLD	226	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RKFLD	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89678
...RKFLD	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89677

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	197	TLES.\|.SRLD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)