P41214: Eukaryotic translation initiation factor 2D

General Information

Protein names	- Eukaryotic translation initiation factor 2D - eIF2d - Hepatocellular carcinoma-associated antigen 56 - Ligatin
Gene names	EIF2D
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P41214

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAHKGDA
        70         80         90        100        110        120
VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP
       130        140        150        160        170        180
PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG
       190        200        210        220        230        240
NKSSPPSIAP LALDSADLSE EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE
       250        260        270        280        290        300
APEDTSTRGL NQDSTDSKTL QEQMDELLQQ CFLHALKCRV KKADLPLLTS TFLGSHMFSC
       310        320        330        340        350        360
CPEGRQLDIK KSSYKKLSKF LQQMQQEQII QVKELSKGVE SIVAVDWKHP RITSFVIPEP
       370        380        390        400        410        420
SPTSQTIQEG SREQPYHPPD IKPLYCVPAS MTLLFQESGH KKGSFLEGSE VRTIVINYAK
       430        440        450        460        470        480
KNDLVDADNK NLVRLDPILC DCILEKNEQH TVMKLPWDSL LTRCLEKLQP AYQVTLPGQE
       490        500        510        520        530        540
PIVKKGRICP IDITLAQRAS NKKVTVVRNL EAYGLDPYSV AAILQQRCQA STTVNPAPGA
       550        560        570        580
KDSLQVQIQG NQVHHLGWLL LEEYQLPRKH IQGLEKALKP GKKK

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 2D

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P41214-1-unknown	MFAKAF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73765
P41214-1-Acetylation	MFAKAF...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P41214-1-Acetylation	MFAKAF...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P41214-1-Acetylation	MFAKAF...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P41214-1-Acetylation	MFAKAF...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105354
P41214-192-unknown	ALDSAD...	192		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14120
P41214-195-unknown	SADLSE...	195		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11503
P41214-209-	STLQGD...	209			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P41214-209-unknown	STLQGD...	209		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11504

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SIAPLA	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14120
...PLALDS	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11503
...SVQMDS	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11504
...PGKKK	584	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PGKKK	584	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69383

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	191	APLA.\|.ALDS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	194	ALDS.\|.SADL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	208	QMDS.\|.STLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)