TopFIND 4.0

P41252: Isoleucine--tRNA ligase, cytoplasmic

General Information

Protein names
- Isoleucine--tRNA ligase, cytoplasmic
- 6.1.1.5 {ECO:0000269|PubMed:8052601}
- Isoleucyl-tRNA synthetase
- IRS
- IleRS
Gene names IARS
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P41252

9

N-termini

4

C-termini

2

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLQQVPENIN FPAEEEKILE FWTEFNCFQE CLKQSKHKPK FTFYDGPPFA TGLPHYGHIL 
        70         80         90        100        110        120 
AGTIKDIVTR YAHQSGFHVD RRFGWDCHGL PVEYEIDKTL GIRGPEDVAK MGITEYNNQC 
       130        140        150        160        170        180 
RAIVMRYSAE WKSTVSRLGR WIDFDNDYKT LYPQFMESVW WVFKQLYDKG LVYRGVKVMP 
       190        200        210        220        230        240 
FSTACNTPLS NFESHQNYKD VQDPSVFVTF PLEEDETVSL VAWTTTPWTL PSNLAVCVNP 
       250        260        270        280        290        300 
EMQYVKIKDV ARGRLLILME ARLSALYKLE SDYEILERFP GAYLKGKKYR PLFDYFLKCK 
       310        320        330        340        350        360 
ENGAFTVLVD NYVKEEEGTG VVHQAPYFGA EDYRVCMDFN IIRKDSLPVC PVDASGCFTT 
       370        380        390        400        410        420 
EVTDFAGQYV KDADKSIIRT LKEQGRLLVA TTFTHSYPFC WRSDTPLIYK AVPSWFVRVE 
       430        440        450        460        470        480 
NMVDQLLRNN DLCYWVPELV REKRFGNWLK DARDWTISRN RYWGTPIPLW VSDDFEEVVC 
       490        500        510        520        530        540 
IGSVAELEEL SGAKISDLHR ESVDHLTIPS RCGKGSLHRI SEVFDCWFES GSMPYAQVHY 
       550        560        570        580        590        600 
PFENKREFED AFPADFIAEG IDQTRGWFYT LLVLATALFG QPPFKNVIVN GLVLASDGQK 
       610        620        630        640        650        660 
MSKRKKNYPD PVSIIQKYGA DALRLYLINS PVVRAENLRF KEEGVRDVLK DVLLPWYNAY 
       670        680        690        700        710        720 
RFLIQNVLRL QKEEEIEFLY NENTVRESPN ITDRWILSFM QSLIGFFETE MAAYRLYTVV 
       730        740        750        760        770        780 
PRLVKFVDIL TNWYVRMNRR RLKGENGMED CVMALETLFS VLLSLCRLMA PYTPFLTELM 
       790        800        810        820        830        840 
YQNLKVLIDP VSVQDKDTLS IHYLMLPRVR EELIDKKTES AVSQMQSVIE LGRVIRDRKT 
       850        860        870        880        890        900 
IPIKYPLKEI VVIHQDPEAL KDIKSLEKYI IEELNVRKVT LSTDKNKYGI RLRAEPDHMV 
       910        920        930        940        950        960 
LGKRLKGAFK AVMTSIKQLS SEELEQFQKT GTIVVEGHEL HDEDIRLMYT FDQATGGTAQ 
       970        980        990       1000       1010       1020 
FEAHSDAQAL VLLDVTPDQS MVDEGMAREV INRIQKLRKK CNLVPTDEIT VYYKAKSEGT 
      1030       1040       1050       1060       1070       1080 
YLNSVIESHT EFIFTTIKAP LKPYPVSPSD KVLIQEKTQL KGSELEITLT RGSSLPGPAC 
      1090       1100       1110       1120       1130       1140 
AYVNLNICAN GSEQGGVLLL ENPKGDNRLD LLKLKSVVTS IFGVKNTELA VFHDETEIQN 
      1150       1160       1170       1180       1190       1200 
QTDLLSLSGK TLCVTAGSAP SLINSSSTLL CQYINLQLLN AKPQECLMGT VGTLLLENPL 
      1210       1220       1230       1240       1250       1260 
GQNGLTHQGL LYEAAKVFGL RSRKLKLFLN ETQTQEITED IPVKTLNMKT VYVSVLPTTA 
   
DF

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)