P49005: DNA polymerase delta subunit 2

General Information

Protein names	- DNA polymerase delta subunit 2 - DNA polymerase delta subunit p50
Gene names	POLD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49005

4 N-termini

8 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFSEQAAQRA HTLLSPPSAN NATFARVPVA TYTNSSQPFR LGERSFSRQY AHIYATRLIQ
        70         80         90        100        110        120
MRPFLENRAQ QHWGSGVGVK KLCELQPEEK CCVVGTLFKA MPLQPSILRE VSEEHNLLPQ
       130        140        150        160        170        180
PPRSKYIHPD DELVLEDELQ RIKLKGTIDV SKLVTGTVLA VFGSVRDDGK FLVEDYCFAD
       190        200        210        220        230        240
LAPQKPAPPL DTDRFVLLVS GLGLGGGGGE SLLGTQLLVD VVTGQLGDEG EQCSAAHVSR
       250        260        270        280        290        300
VILAGNLLSH STQSRDSINK AKYLTKKTQA ASVEAVKMLD EILLQLSASV PVDVMPGEFD
       310        320        330        340        350        360
PTNYTLPQQP LHPCMFPLAT AYSTLQLVTN PYQATIDGVR FLGTSGQNVS DIFRYSSMED
       370        380        390        400        410        420
HLEILEWTLR VRHISPTAPD TLGCYPFYKT DPFIFPECPH VYFCGNTPSF GSKIIRGPED
       430        440        450        460
QTVLLVTVPD FSATQTACLV NLRSLACQPI SFSGFGAEDD DLGGLGLGP

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 8 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49005-1-Acetylation	MFSEQA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49005-1-Acetylation	MFSEQA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49005-1-Acetylation	MFSEQA...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P49005-1-Acetylation	MFSEQA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49005-126-	YIHPDD...	126			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49005-126-	YIHPDD...	126			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49005-131-unknown	DELVLE...	131		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11567
P49005-261-unknown	AKYLTK...	261		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399447

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...YIHPDD	130	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11567
...LKGTID	148	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406702
...SKLVTG	155	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000397461
...QLLVDV	220	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000389816
...TIDGVR	339	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000416203
...DHLEIL	364	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399447
...LGLGP	469	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LGLGP	469		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LGLGP	469		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	130	HPDD.\|.DELV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)