P49006: MARCKS-related protein

General Information

Protein names	- MARCKS-related protein - MARCKS-like protein 1 - Macrophage myristoylated alanine-rich C kinase substrate - Mac-MARCKS - MacMARCKS
Gene names	MARCKSL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49006

19 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGSQSSKAPR GDVTAEEAAG ASPAKANGQE NGHVKSNGDL SPKGEGESPP VNGTDEAAGA
        70         80         90        100        110        120
TGDAIEPAPP SQGAEAKGEV PPKETPKKKK KFSFKKPFKL SGLSFKRNRK EGGGDSSASS
       130        140        150        160        170        180
PTEEEQEQGE IGACSDEGTA QEGKAAATPE SQEPQAKGAE ASAASEEEAG PQATEPSTPS
       190
GPESGPTPAS AEQNE

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

19 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49006-2-unknown	GSQSSK...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49006-2-unknown	GSQSSK...	2		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P49006-2-unknown	GSQSSK...	2			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49006-2-unknown	GSQSSK...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49006-2-	GSQSSK...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49006-2-acetylation	GSQSSK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49006-26-	ANGQEN...	26			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P49006-53-	GTDEAA...	53			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49006-53-	GTDEAA...	53			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P49006-53-	GTDEAA...	53			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P49006-53-	GTDEAA...	53			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49006-53-	GTDEAA...	53			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49006-53-unknown	GTDEAA...	53			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49006-57-unknown	AAGATG...	57			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49006-57-	AAGATG...	57			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49006-57-	AAGATG...	57			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49006-57-	AAGATG...	57			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49006-57-	AAGATG...	57			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49006-57-	AAGATG...	57			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P49006-58-unknown	AGATGD...	58			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49006-58-	AGATGD...	58			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49006-58-	AGATGD...	58			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49006-59-unknown	GATGDA...	59			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49006-59-	GATGDA...	59			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49006-59-	GATGDA...	59			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49006-60-unknown	ATGDAI...	60			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49006-60-	ATGDAI...	60			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49006-60-	ATGDAI...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49006-64-unknown	AIEPAP...	64			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49006-64-	AIEPAP...	64			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P49006-64-	AIEPAP...	64			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49006-64-	AIEPAP...	64			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49006-64-	AIEPAP...	64			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P49006-64-	AIEPAP...	64			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49006-64-	AIEPAP...	64			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49006-64-	AIEPAP...	64			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P49006-64-	AIEPAP...	64			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49006-96-	KPFKLS...	96			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P49006-96-unknown	KPFKLS...	96			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49006-133-unknown	ACSDEG...	133		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7487

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...QGEIGA	132	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7487
	...AEQNE	195	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	132	EIGA.\|.ACSD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)