P49257: Protein ERGIC-53

General Information

Protein names	- Protein ERGIC-53 - ER-Golgi intermediate compartment 53 kDa protein - Gp58 - Intracellular mannose-specific lectin MR60 - Lectin mannose-binding 1
Gene names	LMAN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49257

5 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGSRQRGLR ARVRPLFCAL LLSLGRFVRG DGVGGDPAVA LPHRRFEYKY SFKGPHLVQS
        70         80         90        100        110        120
DGTVPFWAHA GNAIPSSDQI RVAPSLKSQR GSVWTKTKAA FENWEVEVTF RVTGRGRIGA
       130        140        150        160        170        180
DGLAIWYAEN QGLEGPVFGS ADLWNGVGIF FDSFDNDGKK NNPAIVIIGN NGQIHYDHQN
       190        200        210        220        230        240
DGASQALASC QRDFRNKPYP VRAKITYYQN TLTVMINNGF TPDKNDYEFC AKVENMIIPA
       250        260        270        280        290        300
QGHFGISAAT GGLADDHDVL SFLTFQLTEP GKEPPTPDKE ISEKEKEKYQ EEFEHFQQEL
       310        320        330        340        350        360
DKKKEEFQKG HPDLQGQPAE EIFESVGDRE LRQVFEGQNR IHLEIKQLNR QLDMILDEQR
       370        380        390        400        410        420
RYVSSLTEEI SKRGAGMPGQ HGQITQQELD TVVKTQHEIL RQVNEMKNSM SETVRLVSGM
       430        440        450        460        470        480
QHPGSAGGVY ETTQHFIDIK EHLHIVKRDI DNLVQRNMPS NEKPKCPELP PFPSCLSTVH
       490        500        510
FIIFVVVQTV LFIGYIMYRS QQEAAAKKFF

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49257-31-unknown	DGVGGD...	31	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49257-31-	DGVGGD...	31		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P49257-62-	GTVPFW...	62		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49257-310-	GHPDLQ...	310		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49257-316-	GQPAEE...	316		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49257-316-	GQPAEE...	316		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49257-316-	GQPAEE...	316		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49257-316-	GQPAEE...	316		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49257-316-	GQPAEE...	316		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...AKKFF	510	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AKKFF	510		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AKKFF	510		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)