P49711: Transcriptional repressor CTCF

General Information

Protein names	- Transcriptional repressor CTCF - 11-zinc finger protein - CCCTC-binding factor - CTCFL paralog
Gene names	CTCF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49711

10 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEGDAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV VQDVNSSVQM
        70         80         90        100        110        120
VMMEQLDPTL LQMKTEVMEG TVAPEAEAAV DDTQIITLQV VNMEEQPINI GELQLVQVPV
       130        140        150        160        170        180
PVTVPVATTS VEELQGAYEN EVSKEGLAES EPMICHTLPL PEGFQVVKVG ANGEVETLEQ
       190        200        210        220        230        240
GELPPQEDPS WQKDPDYQPP AKKTKKTKKS KLRYTEEGKD VDVSVYDFEE EQQEGLLSEV
       250        260        270        280        290        300
NAEKVVGNMK PPKPTKIKKK GVKKTFQCEL CSYTCPRRSN LDRHMKSHTD ERPHKCHLCG
       310        320        330        340        350        360
RAFRTVTLLR NHLNTHTGTR PHKCPDCDMA FVTSGELVRH RRYKHTHEKP FKCSMCDYAS
       370        380        390        400        410        420
VEVSKLKRHI RSHTGERPFQ CSLCSYASRD TYKLKRHMRT HSGEKPYECY ICHARFTQSG
       430        440        450        460        470        480
TMKMHILQKH TENVAKFHCP HCDTVIARKS DLGVHLRKQH SYIEQGKKCR YCDAVFHERY
       490        500        510        520        530        540
ALIQHQKSHK NEKRFKCDQC DYACRQERHM IMHKRTHTGE KPYACSHCDK TFRQKQLLDM
       550        560        570        580        590        600
HFKRYHDPNF VPAAFVCSKC GKTFTRRNTM ARHADNCAGP DGVEGENGGE TKKSKRGRKR
       610        620        630        640        650        660
KMRSKKEDSS DSENAEPDLD DNEDEEEPAV EIEPEPEPQP VTPAPPPAKK RRGRPPGRTN
       670        680        690        700        710        720
QPKQNQPTAI IQVEDQNTGA IENIIVEVKK EPDAEPAEGE EEEAQPAATD APNGDLTPEM

ILSMMDR

Isoforms

- Isoform 2 of Transcriptional repressor CTCF

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49711-1-Acetylation	MEGDAV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49711-1-Acetylation	MEGDAV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49711-1-Acetylation	MEGDAV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49711-5-unknown	AVEAIV...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11592
P49711-5-	AVEAIV...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49711-13-unknown	SETFIK...	13		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11593
P49711-47-	GGEVVQ...	47			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49711-50-	VVQDVN...	50			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49711-60-	MVMMEQ...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49711-60-	MVMMEQ...	60			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49711-60-	MVMMEQ...	60			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49711-61-	VMMEQL...	61			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49711-61-	VMMEQL...	61			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49711-61-	VMMEQL...	61			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49711-223-unknown	VSVYDF...	223		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11594
P49711-329-unknown	MAFVTS...	329		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71995

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AIVEES	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11593
...GKDVDV	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11594
...SMMDR	727	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SMMDR	727	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67613

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	4	EGDA.\|.AVEA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	12	VEES.\|.SETF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	222	DVDV.\|.VSVY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)