P51116: Fragile X mental retardation syndrome-related protein 2

General Information

Protein names	- Fragile X mental retardation syndrome-related protein 2
Gene names	FXR2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51116

9 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER QIPFGDVRLP
        70         80         90        100        110        120
PPADYNKEIT EGDEVEVYSR ANEQEPCGWW LARVRMMKGD FYVIEYAACD ATYNEIVTLE
       130        140        150        160        170        180
RLRPVNPNPL ATKGSFFKVT MAVPEDLREA CSNENVHKEF KKALGANCIF LNITNSELFI
       190        200        210        220        230        240
LSTTEAPVKR ASLLGDMHFR SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM
       250        260        270        280        290        300
GLAIGTHGAN IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR
       310        320        330        340        350        360
NLVGKVIGKN GKVIQEIVDK SGVVRVRVEG DNDKKNPREE GMVPFIFVGT RENISNAQAL
       370        380        390        400        410        420
LEYHLSYLQE VEQLRLERLQ IDEQLRQIGL GFRPPGSGRG SGGSDKAGYS TDESSSSSLH
       430        440        450        460        470        480
ATRTYGGSYG GRGRGRRTGG PAYGPSSDVS TASETESEKR EEPNRAGPGD RDPPTRGEES
       490        500        510        520        530        540
RRRPTGGRGR GPPPAPRPTS RYNSSSISSV LKDPDSNPYS LLDTSEPEPP VDSEPGEPPP
       550        560        570        580        590        600
ASARRRRSRR RRTDEDRTVM DGGLESDGPN MTENGLEDES RPQRRNRSRR RRNRGNRTDG
       610        620        630        640        650        660
SISGDRQPVT VADYISRAES QSRQRPPLER TKPSEDSLSG QKGDSVSKLP KGPSENGELS
       670
APLELGSMVN GVS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P51116-1-unknown	MGGLAS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51116-2-unknown	GGLASG...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P51116-2-	GGLASG...	2		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P51116-2-	GGLASG...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P51116-2-	GGLASG...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P51116-2-	GGLASG...	2		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P51116-2-	GGLASG...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P51116-449-unknown	VSTASE...	449	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11628
P51116-520-	SLLDTS...	520		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P51116-562-	GGLESD...	562		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P51116-568-unknown	GPNMTE...	568	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3085
P51116-606-	RQPVTV...	606		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P51116-606-unknown	RQPVTV...	606		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HKEFKK	161	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459230
...GPSSDV	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11628
...GLESDG	567	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3085
...VNGVS	673	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	448	SSDV.\|.VSTA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP8_HUMAN	567	ESDG.\|.GPNM	inferred from experiment	unknown	MEROPS	Liu R	Ju W et al.:Proteome-wide identification of... (C14.009)	17728405,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)