P52294: Importin subunit alpha-5

General Information

Protein names	- Importin subunit alpha-5 - Karyopherin subunit alpha-1 - Nucleoprotein interactor 1 - NPI-1 - RAG cohort protein 2 - SRP1-beta - Importin subunit alpha-5, N-terminally processed
Gene names	KPNA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52294

4 N-termini

7 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTTPGKENFR LKSYKNKSLN PDEMRRRREE EGLQLRKQKR EEQLFKRRNV ATAEEETEEE
        70         80         90        100        110        120
VMSDGGFHEA QISNMEMAPG GVITSDMIEM IFSKSPEQQL SATQKFRKLL SKEPNPPIDE
       130        140        150        160        170        180
VISTPGVVAR FVEFLKRKEN CTLQFESAWV LTNIASGNSL QTRIVIQAGA VPIFIELLSS
       190        200        210        220        230        240
EFEDVQEQAV WALGNIAGDS TMCRDYVLDC NILPPLLQLF SKQNRLTMTR NAVWALSNLC
       250        260        270        280        290        300
RGKSPPPEFA KVSPCLNVLS WLLFVSDTDV LADACWALSY LSDGPNDKIQ AVIDAGVCRR
       310        320        330        340        350        360
LVELLMHNDY KVVSPALRAV GNIVTGDDIQ TQVILNCSAL QSLLHLLSSP KESIKKEACW
       370        380        390        400        410        420
TISNITAGNR AQIQTVIDAN IFPALISILQ TAEFRTRKEA AWAITNATSG GSAEQIKYLV
       430        440        450        460        470        480
ELGCIKPLCD LLTVMDSKIV QVALNGLENI LRLGEQEAKR NGTGINPYCA LIEEAYGLDK
       490        500        510        520        530
IEFLQSHENQ EIYQKAFDLI EHYFGTEDED SSIAPQVDLN QQQYIFQQCE APMEGFQL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 7 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52294-1-Acetylation	MTTPGK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52294-1-Acetylation	MTTPGK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P52294-1-Acetylation	MTTPGK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P52294-2-Acetylation	TTPGKE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52294-2-Acetylation	TTPGKE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P52294-2-Acetylation	TTPGKE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P52294-2-Acetylation	TTPGKE...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P52294-65-unknown	GGFHEA...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11654
P52294-65-unknown	GGFHEA...	65			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52294-407-unknown	ATSGGS...	407		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7543
P52294-407-unknown	ATSGGS...	407		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52294-407-unknown	ATSGGS...	407		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVMSDG	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11654
...AVPIFI	174	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419257
...DCNILP	213	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417319
...CNILPP	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417166
...VTGDDI	328	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419890
...WAITNA	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7543
...EGFQL	538	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	64	MSDG.\|.GGFH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	406	ITNA.\|.ATSG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)