P53990: IST1 homolog
Protein names | - IST1 homolog - hIST1 - Putative MAPK-activating protein PM28 |
---|---|
Gene names | IST1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P53990 |
7
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII
70 80 90 100 110 120
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV
130 140 150 160 170 180
ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD
190 200 210 220 230 240
SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN
250 260 270 280 290 300
TPFSYPLPKG PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
310 320 330 340 350 360
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL
KKKT
Isoforms
- Isoform 2 of IST1 homolog - Isoform 5 of IST1 homolog - Isoform 4 of IST1 homolog - Isoform 3 of IST1 homolog - Isoform 6 of IST1 homologSequence View
10 20 30 40 50 60
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII
70 80 90 100 110 120
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV
130 140 150 160 170 180
ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD
190 200 210 220 230 240
SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN
250 260 270 280 290 300
TPFSYPLPKG PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
310 320 330 340 350 360
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL
KKKT
10 20 30 40 50 60
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII
70 80 90 100 110 120
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV
130 140 150 160 170 180
ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD
190 200 210 220 230 240
SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN
250 260 270 280 290 300
TPFSYPLPKG PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
310 320 330 340 350 360
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL
KKKT
10 20 30 40 50 60
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII
70 80 90 100 110 120
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV
130 140 150 160 170 180
ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD
190 200 210 220 230 240
SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN
250 260 270 280 290 300
TPFSYPLPKG PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
310 320 330 340 350 360
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL
KKKT
10 20 30 40 50 60
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII
70 80 90 100 110 120
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV
130 140 150 160 170 180
ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD
190 200 210 220 230 240
SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN
250 260 270 280 290 300
TPFSYPLPKG PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
310 320 330 340 350 360
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL
KKKT
10 20 30 40 50 60
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII
70 80 90 100 110 120
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV
130 140 150 160 170 180
ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD
190 200 210 220 230 240
SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN
250 260 270 280 290 300
TPFSYPLPKG PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
310 320 330 340 350 360
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL
KKKT
Protein Neighborhood
Domains & Features
7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P53990-1-acetylation | MLGSGF... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P53990-1-acetylation | MLGSGF... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P53990-1-acetylation | MLGSGF... | 1 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P53990-1-acetylation | MLGSGF... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt163104 | ||
P53990-1-acetylation | MLGSGF... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt163105 | ||
P53990-1-acetylation | MLGSGF... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt163107 | ||
P53990-1-acetylation | MLGSGF... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt163106 | ||
P53990-1-unknown | MLGSGF... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P53990-1-unknown | MLGSGF... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78114 | |||
P53990-1-unknown | MLGSGF... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78116 | |||
P53990-1-unknown | MLGSGF... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78117 | |||
P53990-1-unknown | MLGSGF... | 1 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P53990-1-unknown | MLGSGF... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt97820 | |||
P53990-1- | MLGSGF... | 1 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P53990-1- | MLGSGF... | 1 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P53990-195-unknown | LIDVGF... | 195 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11668 | |||
P53990-195-unknown | LIDVGF... | 195 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146433 | |||
P53990-195-unknown | LIDVGF... | 195 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146434 | |||
P53990-195-unknown | LIDVGF... | 195 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146436 | |||
P53990-195-unknown | LIDVGF... | 195 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146853 | |||
P53990-224- | PDGTVP... | 224 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P53990-296- | QIVGPG... | 296 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P53990-296-unknown | QIVGPG... | 296 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174231 | |||
P53990-296-unknown | QIVGPG... | 296 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174229 | |||
P53990-296-unknown | QIVGPG... | 296 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174230 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GVETDL | 194 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11668 | |||
...GVETDL | 194 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129738 | |||
...GVETDL | 194 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129739 | |||
...GVETDL | 194 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129741 | |||
...GVETDL | 194 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130179 | |||
...LKKKT | 364 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...LKKKT | 364 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73732 | |||
...LKKKT | 364 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73734 | |||
...LKKKT | 364 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73733 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 194 | ETDL.|.LIDV | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|