P54252: Ataxin-3
Protein names | - Ataxin-3 - 3.4.19.12 - Machado-Joseph disease protein 1 - Spinocerebellar ataxia type 3 protein |
---|---|
Gene names | ATXN3 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | C86.001 |
Chromosome location | |
UniProt ID | P54252 |
15
N-termini
8
C-termini
7
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT
70 80 90 100 110 120
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW
130 140 150 160 170 180
FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM
190 200 210 220 230 240
IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI
250 260 270 280 290 300
DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ
310 320 330 340 350 360
QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK
K
Isoforms
- Isoform 2 of Ataxin-3 - Isoform 3 of Ataxin-3 - Isoform 4 of Ataxin-3 - Isoform 5 of Ataxin-3 - Isoform 1 of Ataxin-3Sequence View
10 20 30 40 50 60
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT
70 80 90 100 110 120
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW
130 140 150 160 170 180
FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM
190 200 210 220 230 240
IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI
250 260 270 280 290 300
DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ
310 320 330 340 350 360
QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK
K
10 20 30 40 50 60
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT
70 80 90 100 110 120
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW
130 140 150 160 170 180
FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM
190 200 210 220 230 240
IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI
250 260 270 280 290 300
DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ
310 320 330 340 350 360
QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK
K
10 20 30 40 50 60
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT
70 80 90 100 110 120
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW
130 140 150 160 170 180
FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM
190 200 210 220 230 240
IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI
250 260 270 280 290 300
DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ
310 320 330 340 350 360
QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK
K
10 20 30 40 50 60
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT
70 80 90 100 110 120
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW
130 140 150 160 170 180
FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM
190 200 210 220 230 240
IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI
250 260 270 280 290 300
DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ
310 320 330 340 350 360
QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK
K
10 20 30 40 50 60
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT
70 80 90 100 110 120
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW
130 140 150 160 170 180
FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM
190 200 210 220 230 240
IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI
250 260 270 280 290 300
DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ
310 320 330 340 350 360
QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK
K
Protein Neighborhood
Domains & Features
15 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P54252-1-unknown | MESIFH... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P54252-1-unknown | MESIFH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt68008 | |||
P54252-1-unknown | MESIFH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt68010 | |||
P54252-146-unknown | TYLALF... | 146 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1905 | |||
P54252-146-unknown | TYLALF... | 146 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141880 | |||
P54252-146-unknown | TYLALF... | 146 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143939 | |||
P54252-146-unknown | TYLALF... | 146 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144569 | |||
P54252-172-unknown | CEADQL... | 172 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1909 | |||
P54252-172-unknown | CEADQL... | 172 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143328 | |||
P54252-172-unknown | CEADQL... | 172 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145033 | |||
P54252-172-unknown | CEADQL... | 172 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145592 | |||
P54252-180-unknown | MIRVQQ... | 180 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt68011 | |||
P54252-180-unknown | MIRVQQ... | 180 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105421 | |||
P54252-180-unknown | MIRVQQ... | 180 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105420 | |||
P54252-180-unknown | MIRVQQ... | 180 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105422 | |||
P54252-218-unknown | GSGMLD... | 218 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170978 | |||
P54252-218-unknown | GSGMLD... | 218 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170980 | |||
P54252-218-unknown | GSGMLD... | 218 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170979 | |||
P54252-218-unknown | GSGMLD... | 218 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170981 | |||
P54252-218- | GSGMLD... | 218 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P54252-218- | GSGMLD... | 218 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P54252-218- | GSGMLD... | 218 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P54252-220-unknown | GMLDED... | 220 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176730 | |||
P54252-220-unknown | GMLDED... | 220 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176732 | |||
P54252-220-unknown | GMLDED... | 220 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176731 | |||
P54252-220-unknown | GMLDED... | 220 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176733 | |||
P54252-220-unknown | GMLDED... | 220 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P54252-220-unknown | GMLDED... | 220 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P54252-220- | GMLDED... | 220 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P54252-221-unknown | MLDEDE... | 221 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170973 | |||
P54252-221-unknown | MLDEDE... | 221 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170975 | |||
P54252-221-unknown | MLDEDE... | 221 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170974 | |||
P54252-221-unknown | MLDEDE... | 221 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170976 | |||
P54252-221- | MLDEDE... | 221 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P54252-221- | MLDEDE... | 221 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P54252-221- | MLDEDE... | 221 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P54252-229-unknown | LQRALA... | 229 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1913 | |||
P54252-229-unknown | LQRALA... | 229 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139174 | |||
P54252-229-unknown | LQRALA... | 229 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145674 | |||
P54252-229-unknown | LQRALA... | 229 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147139 | |||
P54252-229-unknown | LQRALA... | 229 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147696 | |||
P54252-242-unknown | MEDEEA... | 242 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1236 | |||
P54252-242-unknown | MEDEEA... | 242 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140201 | |||
P54252-242-unknown | MEDEEA... | 242 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146159 | |||
P54252-242-unknown | MEDEEA... | 242 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147642 | |||
P54252-242-unknown | MEDEEA... | 242 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148187 | |||
P54252-245-unknown | EEADLR... | 245 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1241 | |||
P54252-245-unknown | EEADLR... | 245 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140391 | |||
P54252-245-unknown | EEADLR... | 245 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146261 | |||
P54252-245-unknown | EEADLR... | 245 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147752 | |||
P54252-245-unknown | EEADLR... | 245 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148278 | |||
P54252-249-unknown | LRRAIQ... | 249 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1246 | |||
P54252-249-unknown | LRRAIQ... | 249 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140670 | |||
P54252-249-unknown | LRRAIQ... | 249 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146408 | |||
P54252-249-unknown | LRRAIQ... | 249 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147890 | |||
P54252-249-unknown | LRRAIQ... | 249 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148395 | |||
P54252-268-unknown | MTQTSG... | 268 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11674 | |||
P54252-268-unknown | MTQTSG... | 268 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141776 | |||
P54252-268-unknown | MTQTSG... | 268 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147109 | |||
P54252-268-unknown | MTQTSG... | 268 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148542 | |||
P54252-268-unknown | MTQTSG... | 268 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149077 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ELISDT | 145 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1905 | |||
...ELISDT | 145 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125058 | |||
...ELISDT | 145 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127182 | |||
...ELISDT | 145 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127836 | |||
...GDLPDC | 171 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1909 | |||
...GDLPDC | 171 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126559 | |||
...GDLPDC | 171 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128312 | |||
...GDLPDC | 171 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128890 | |||
...EDEEDL | 228 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1913 | |||
...EDEEDL | 228 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122249 | |||
...EDEEDL | 228 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128972 | |||
...EDEEDL | 228 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130474 | |||
...EDEEDL | 228 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131049 | |||
...RQEIDM | 241 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1236 | |||
...RQEIDM | 241 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123315 | |||
...RQEIDM | 241 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129462 | |||
...RQEIDM | 241 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130996 | |||
...RQEIDM | 241 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131554 | |||
...IDMEDE | 244 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1241 | |||
...IDMEDE | 244 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123514 | |||
...IDMEDE | 244 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129565 | |||
...IDMEDE | 244 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131107 | |||
...IDMEDE | 244 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131648 | |||
...DEEADL | 248 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1246 | |||
...DEEADL | 248 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123805 | |||
...DEEADL | 248 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129713 | |||
...DEEADL | 248 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131250 | |||
...DEEADL | 248 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131767 | |||
...NISQDM | 267 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11674 | |||
...NISQDM | 267 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124956 | |||
...NISQDM | 267 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130443 | |||
...NISQDM | 267 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131916 | |||
...NISQDM | 267 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132461 | |||
...KK | 364 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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