P57772: Selenocysteine-specific elongation factor

General Information

Protein names	- Selenocysteine-specific elongation factor - Elongation factor sec - Eukaryotic elongation factor, selenocysteine-tRNA-specific
Gene names	EEFSEC
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P57772

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGRRVNVNV GVLGHIDSGK TALARALSTT ASTAAFDKQP QSRERGITLD LGFSCFSVPL
        70         80         90        100        110        120
PARLRSSLPE FQAAPEAEPE PGEPLLQVTL VDCPGHASLI RTIIGGAQII DLMMLVIDVT
       130        140        150        160        170        180
KGMQTQSAEC LVIGQIACQK LVVVLNKIDL LPEGKRQAAI DKMTKKMQKT LENTKFRGAP
       190        200        210        220        230        240
IIPVAAKPGG PEAPETEAPQ GIPELIELLT SQISIPTRDP SGPFLMSVDH CFSIKGQGTV
       250        260        270        280        290        300
MTGTILSGSI SLGDSVEIPA LKVVKKVKSM QMFHMPITSA MQGDRLGICV TQFDPKLLER
       310        320        330        340        350        360
GLVCAPESLH TVHAALISVE KIPYFRGPLQ TKAKFHITVG HETVMGRLMF FSPAPDNFDQ
       370        380        390        400        410        420
EPILDSFNFS QEYLFQEQYL SKDLTPAVTD NDEADKKAGQ ATEGHCPRQQ WALVEFEKPV
       430        440        450        460        470        480
TCPRLCLVIG SRLDADIHTN TCRLAFHGIL LHGLEDRNYA DSFLPRLKVY KLKHKHGLVE
       490        500        510        520        530        540
RAMDDYSVIG RSLFKKETNI QLFVGLKVHL STGELGIIDS AFGQSGKFKI HIPGGLSPES
       550        560        570        580        590
KKILTPALKK RARAGRGEAT RQEESAERSE PSQHVVLSLT FKRYVFDTHK RMVQSP

Isoforms

- Isoform 2 of Selenocysteine-specific elongation factor

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P57772-1-unknown	MAGRRV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P57772-26-	ALSTTA...	26		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P57772-26-	ALSTTA...	26		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P57772-26-	ALSTTA...	26		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P57772-26-	ALSTTA...	26		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P57772-26-	ALSTTA...	26		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P57772-448-unknown	GILLHG...	448	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3872

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...RLAFHG	447	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3872
	...MVQSP	596	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	447	AFHG.\|.GILL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)