P62158: Calmodulin

General Information

Protein names	- Calmodulin - CaM
Gene names	CALM3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location	q13.32
UniProt ID	P62158

10 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG
        70         80         90        100        110        120
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE
       130        140
EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62158-2-unknown	MADQLT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62158-2-Acetylation	ADQLTE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62158-2-Acetylation	ADQLTE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P62158-2-Acetylation	ADQLTE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P62158-7-unknown	EEQIAE...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7633
P62158-19-unknown	LFDKDG...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7634
P62158-37-unknown	MRSLGQ...	37		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000375785
P62158-37-unknown	MRSLGQ...	37		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470502
P62158-37-unknown	MRSLGQ...	37		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468877
P62158-37-unknown	MRSLGQ...	37		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000471225
P62158-37-unknown	MRSLGQ...	37		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451062
P62158-37-unknown	MRSLGQ...	37		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450829
P62158-37-unknown	MRSLGQ...	37		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442853
P62158-62-	GTIDFP...	62			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P62158-62-	GTIDFP...	62			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62158-76-unknown	KMKDTD...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11762
P62158-92-	VFDKDG...	92			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P62158-94-	DKDGNG...	94			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62158-99-	GYISAA...	99			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62158-99-	GYISAA...	99			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62158-99-	GYISAA...	99			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P62158-99-	GYISAA...	99			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62158-99-	GYISAA...	99			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ADQLTE	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7633
...KEAFSL	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7634
...TMMARK	75	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11762
...DIDGDG	134	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451062
...MMTAK	149		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...MMTAK	149		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...MMTAK	149	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...MMTAK	149		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...MMTAK	149		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	6	QLTE.\|.EEQI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	18	AFSL.\|.LFDK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	75	MARK.\|.KMKD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)