TopFIND 4.0

P62805: Histone H4

General Information

Protein names	- Histone H4
Gene names	HIST4H4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62805

9

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
70 80 90 100
VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62805-2-unknown	MSGRGK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62805-2-Acetylation	SGRGKG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62805-10-unknown	GLGKGG...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10137
P62805-26-	NIQGIT...	26			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62805-26-	NIQGIT...	26			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62805-61-	VFLENV...	61			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P62805-70-	AVTYTE...	70			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62805-79-	RKTVTA...	79			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62805-80-	KTVTAM...	80			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62805-82-	VTAMDV...	82			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62805-82-	VTAMDV...	82			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62805-82-	VTAMDV...	82			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P62805-82-	VTAMDV...	82			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...GKGGKG	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10137
	...YGFGG	103	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	9	GGKG.\|.GLGK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)