P62917: 60S ribosomal protein L8

General Information

Protein names	- 60S ribosomal protein L8 - Large ribosomal subunit protein uL2 {ECO:0000303\|PubMed:24524803}
Gene names	RPL8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62917

9 N-termini

6 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK
        70         80         90        100        110        120
VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP
       130        140        150        160        170        180
GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS ANRAVVGVVA GGGRIDKPIL
       190        200        210        220        230        240
KAGRAYHKYK AKRNCWPRVR GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA
       250
RRTGRLRGTK TVQEKEN

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62917-2-unknown	GRVIRG...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62917-10-unknown	KGAGSV...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10150
P62917-74-unknown	ELFIAA...	74	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P62917-129-	ASGNYA...	129		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62917-133-	YATVIS...	133		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62917-136-unknown	VISHNP...	136	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3898
P62917-164-	AVVGVV...	164		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62917-168-	VVAGGG...	168		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62917-175-	IDKPIL...	175		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IRGQRK	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10150
...GNYATV	135	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3898
...GVAMNP	205	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434535
...VQEKEN	256	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435313
...QEKEN	257	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QEKEN	257		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QEKEN	257		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...QEKEN	257		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QEKEN	257		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	9	GQRK.\|.KGAG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATB_HUMAN	135	YATV.\|.VISH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)