P68032: Actin, alpha cardiac muscle 1

General Information

Protein names	- Actin, alpha cardiac muscle 1 - Alpha-cardiac actin - Actin, alpha cardiac muscle 1, intermediate form
Gene names	ACTC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P68032

8 N-termini

8 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MCDDEETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA
        70         80         90        100        110        120
QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP EEHPTLLTEA PLNPKANREK
       130        140        150        160        170        180
MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL
       190        200        210        220        230        240
DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK
       250        260        270        280        290        300
SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV
       310        320        330        340        350        360
LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS
       370
KQEYDEAGPS IVHRKCF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P68032-3-Acetylation	DDEETT...	3	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P68032-3-Acetylation	DDEETT...	3	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P68032-20-unknown	KAGFAG...	20		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15344
P68032-21-unknown	AGFAGD...	21		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10155
P68032-50-unknown	GQKDSY...	50		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14292
P68032-50-unknown	GQKDSY...	50		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P68032-50-unknown	GQKDSY...	50		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P68032-54-unknown	SYVGDE...	54		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11801
P68032-54-unknown	SYVGDE...	54		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1980
P68032-108-unknown	TEAPLN...	108		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15345
P68032-109-unknown	EAPLNP...	109		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15346
P68032-219-unknown	CYVALD...	219		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14293

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GSGLVK	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15344
...SGLVKA	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10155
...VMVGMG	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14292
...MGQKDS	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11801
...MGQKDS	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1980
...HPTLLT	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15345
...PTLLTE	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15346
...IKEKLC	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14293
...HRKCF	377	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HTRA2_HUMAN	19	GLVK.\|.KAGF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	20	LVKA.\|.AGFA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	49	VGMG.\|.GQKD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	53	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP3_HUMAN	53	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
HTRA2_HUMAN	107	TLLT.\|.TEAP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	108	LLTE.\|.EAPL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	218	EKLC.\|.CYVA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)