P78316: Nucleolar protein 14

General Information

Protein names	- Nucleolar protein 14 - Nucleolar complex protein 14
Gene names	NOP14
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P78316

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAKAKKVGAR RKASGAPAGA RGGPAKANSN PFEVKVNRQK FQILGRKTRH DVGLPGVSRA
        70         80         90        100        110        120
RALRKRTQTL LKEYKERDKS NVFRDKRFGE YNSNMSPEEK MMKRFALEQQ RHHEKKSIYN
       130        140        150        160        170        180
LNEDEELTHY GQSLADIEKH NDIVDSDSDA EDRGTLSAEL TAAHFGGGGG LLHKKTQQEG
       190        200        210        220        230        240
EEREKPKSRK ELIEELIAKS KQEKRERQAQ REDALELTEK LDQDWKEIQT LLSHKTPKSE
       250        260        270        280        290        300
NRDKKEKPKP DAYDMMVREL GFEMKAQPSN RMKTEAELAK EEQEHLRKLE AERLRRMLGK
       310        320        330        340        350        360
DEDENVKKPK HMSADDLNDG FVLDKDDRRL LSYKDGKMNV EEDVQEEQSK EASDPESNEE
       370        380        390        400        410        420
EGDSSGGEDT EESDSPDSHL DLESNVESEE ENEKPAKEQR QTPGKGLISG KERAGKATRD
       430        440        450        460        470        480
ELPYTFAAPE SYEELRSLLL GRSMEEQLLV VERIQKCNHP SLAEGNKAKL EKLFGFLLEY
       490        500        510        520        530        540
VGDLATDDPP DLTVIDKLVV HLYHLCQMFP ESASDAIKFV LRDAMHEMEE MIETKGRAAL
       550        560        570        580        590        600
PGLDVLIYLK ITGLLFPTSD FWHPVVTPAL VCLSQLLTKC PILSLQDVVK GLFVCCLFLE
       610        620        630        640        650        660
YVALSQRFIP ELINFLLGIL YIATPNKASQ GSTLVHPFRA LGKNSELLVV SAREDVATWQ
       670        680        690        700        710        720
QSSLSLRWAS RLRAPTSTEA NHIRLSCLAV GLALLKRCVL MYGSLPSFHA IMGPLQALLT
       730        740        750        760        770        780
DHLADCSHPQ ELQELCQSTL TEMESQKQLC RPLTCEKSKP VPLKLFTPRL VKVLEFGRKQ
       790        800        810        820        830        840
GSSKEEQERK RLIHKHKREF KGAVREIRKD NQFLARMQLS EIMERDAERK RKVKQLFNSL
       850
ATQEGEWKAL KRKKFKK

Isoforms

- Isoform 2 of Nucleolar protein 14

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P78316-1-unknown	MAKAKK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78316-1-unknown	MAKAKK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83038
P78316-2-unknown	AKAKKV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P78316-2-unknown	AKAKKV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P78316-2-unknown	AKAKKV...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162782
P78316-252-unknown	AYDMMV...	252	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11826
P78316-252-unknown	AYDMMV...	252	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148477
P78316-320-unknown	GFVLDK...	320		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P78316-320-unknown	GFVLDK...	320	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161880
P78316-320-	GFVLDK...	320		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P78316-320-	GFVLDK...	320		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P78316-344-unknown	VQEEQS...	344	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11828
P78316-344-unknown	VQEEQS...	344	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150818
P78316-378-unknown	SHLDLE...	378	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176223
P78316-378-	SHLDLE...	378		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P78316-378-	SHLDLE...	378		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KPKPDA	251	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11826
...KPKPDA	251	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt131850
...NVEEDV	343	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11828
...NVEEDV	343	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134220
...KKFKK	857		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KKFKK	857	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KKFKK	857		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	251	KPDA.\|.AYDM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	343	EEDV.\|.VQEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)