Q01081: Splicing factor U2AF 35 kDa subunit

General Information

Protein names	- Splicing factor U2AF 35 kDa subunit - U2 auxiliary factor 35 kDa subunit - U2 small nuclear RNA auxiliary factor 1 - U2 snRNP auxiliary factor small subunit
Gene names	U2AF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01081

9 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Splicing factor U2AF 35 kDa subunit - Isoform 3 of Splicing factor U2AF 35 kDa subunit - Isoform 4 of Splicing factor U2AF 35 kDa subunit

Sequence View

        10         20         30         40         50         60
MAEYLASIFG TEKDKVNCSF YFKIGACRHG DRCSRLHNKP TFSQTIALLN IYRNPQNSSQ
        70         80         90        100        110        120
SADGLRCAVS DVEMQEHYDE FFEEVFTEME EKYGEVEEMN VCDNLGDHLV GNVYVKFRRE
       130        140        150        160        170        180
EDAEKAVIDL NNRWFNGQPI HAELSPVTDF REACCRQYEM GECTRGGFCN FMHLKPISRE
       190        200        210        220        230        240
LRRELYGRRR KKHRSRSRSR ERRSRSRDRG RGGGGGGGGG GGGRERDRRR SRDRERSGRF

        10         20         30         40         50         60
MAEYLASIFG TEKDKVNCSF YFKIGACRHG DRCSRLHNKP TFSQTIALLN IYRNPQNSSQ
        70         80         90        100        110        120
SADGLRCAVS DVEMQEHYDE FFEEVFTEME EKYGEVEEMN VCDNLGDHLV GNVYVKFRRE
       130        140        150        160        170        180
EDAEKAVIDL NNRWFNGQPI HAELSPVTDF REACCRQYEM GECTRGGFCN FMHLKPISRE
       190        200        210        220        230        240
LRRELYGRRR KKHRSRSRSR ERRSRSRDRG RGGGGGGGGG GGGRERDRRR SRDRERSGRF

        10         20         30         40         50         60
MAEYLASIFG TEKDKVNCSF YFKIGACRHG DRCSRLHNKP TFSQTIALLN IYRNPQNSSQ
        70         80         90        100        110        120
SADGLRCAVS DVEMQEHYDE FFEEVFTEME EKYGEVEEMN VCDNLGDHLV GNVYVKFRRE
       130        140        150        160        170        180
EDAEKAVIDL NNRWFNGQPI HAELSPVTDF REACCRQYEM GECTRGGFCN FMHLKPISRE
       190        200        210        220        230        240
LRRELYGRRR KKHRSRSRSR ERRSRSRDRG RGGGGGGGGG GGGRERDRRR SRDRERSGRF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01081-2-unknown	MAEYLA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01081-1-unknown	MAEYLA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93513
Q01081-1-unknown	MAEYLA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93514
Q01081-2-Acetylation	AEYLAS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01081-2-Acetylation	AEYLAS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q01081-2-Acetylation	AEYLAS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110270
Q01081-2-Acetylation	AEYLAS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110271
Q01081-51-	IYRNPQ...	51			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q01081-54-unknown	NPQNSS...	54		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10182
Q01081-58-	SSQSAD...	58			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01081-74-unknown	MQEHYD...	74		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93515
Q01081-74-unknown	MQEHYD...	74		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100177
Q01081-137-unknown	GQPIHA...	137		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167931
Q01081-137-unknown	GQPIHA...	137		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167932
Q01081-137-	GQPIHA...	137			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q01081-137-	GQPIHA...	137			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01081-137-	GQPIHA...	137			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q01081-137-	GQPIHA...	137			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q01081-137-	GQPIHA...	137			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q01081-137-	GQPIHA...	137			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LNIYRN	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10182
...RSGRF	240	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RSGRF	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89133
...RSGRF	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89131

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	53	IYRN.\|.NPQN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)