Q01433: AMP deaminase 2

General Information

Protein names	- AMP deaminase 2 - 3.5.4.6 - AMP deaminase isoform L
Gene names	AMPD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01433

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Ex1A-2-3 of AMP deaminase 2 - Isoform Ex1A-3 of AMP deaminase 2 - Isoform Ex1B-3 of AMP deaminase 2 - Isoform 5 of AMP deaminase 2

Sequence View

        10         20         30         40         50         60
MRNRGQGLFR LRSRCFLHQS LPLGAGRRKG LDVAEPGPSR CRSDSPAVAA VVPAMASYPS
        70         80         90        100        110        120
GSGKPKAKYP FKKRASLQAS TAAPEARGGL GAPPLQSARS LPGPAPCLKH FPLDLRTSMD
       130        140        150        160        170        180
GKCKEIAEEL FTRSLAESEL RSAPYEFPEE SPIEQLEERR QRLERQISQD VKLEPDILLR
       190        200        210        220        230        240
AKQDFLKTDS DSDLQLYKEQ GEGQGDRSLR ERDVLEREFQ RVTISGEEKC GVPFTDLLDA
       250        260        270        280        290        300
AKSVVRALFI REKYMALSLQ SFCPTTRRYL QQLAEKPLET RTYEQGPDTP VSADAPVHPP
       310        320        330        340        350        360
ALEQHPYEHC EPSTMPGDLG LGLRMVRGVV HVYTRREPDE HCSEVELPYP DLQEFVADVN
       370        380        390        400        410        420
VLMALIINGP IKSFCYRRLQ YLSSKFQMHV LLNEMKELAA QKKVPHRDFY NIRKVDTHIH
       430        440        450        460        470        480
ASSCMNQKHL LRFIKRAMKR HLEEIVHVEQ GREQTLREVF ESMNLTAYDL SVDTLDVHAD
       490        500        510        520        530        540
RNTFHRFDKF NAKYNPIGES VLREIFIKTD NRVSGKYFAH IIKEVMSDLE ESKYQNAELR
       550        560        570        580        590        600
LSIYGRSRDE WDKLARWAVM HRVHSPNVRW LVQVPRLFDV YRTKGQLANF QEMLENIFLP
       610        620        630        640        650        660
LFEATVHPAS HPELHLFLEH VDGFDSVDDE SKPENHVFNL ESPLPEAWVE EDNPPYAYYL
       670        680        690        700        710        720
YYTFANMAML NHLRRQRGFH TFVLRPHCGE AGPIHHLVSA FMLAENISHG LLLRKAPVLQ
       730        740        750        760        770        780
YLYYLAQIGI AMSPLSNNSL FLSYHRNPLP EYLSRGLMVS LSTDDPLQFH FTKEPLMEEY
       790        800        810        820        830        840
SIATQVWKLS SCDMCELARN SVLMSGFSHK VKSHWLGPNY TKEGPEGNDI RRTNVPDIRV
       850        860        870
GYRYETLCQE LALITQAVQS EMLETIPEEA GITMSPGPQ         10         20         30         40         50         60
MRNRGQGLFR LRSRCFLHQS LPLGAGRRKG LDVAEPGPSR CRSDSPAVAA VVPAMASYPS
        70         80         90        100        110        120
GSGKPKAKYP FKKRASLQAS TAAPEARGGL GAPPLQSARS LPGPAPCLKH FPLDLRTSMD
       130        140        150        160        170        180
GKCKEIAEEL FTRSLAESEL RSAPYEFPEE SPIEQLEERR QRLERQISQD VKLEPDILLR
       190        200        210        220        230        240
AKQDFLKTDS DSDLQLYKEQ GEGQGDRSLR ERDVLEREFQ RVTISGEEKC GVPFTDLLDA
       250        260        270        280        290        300
AKSVVRALFI REKYMALSLQ SFCPTTRRYL QQLAEKPLET RTYEQGPDTP VSADAPVHPP
       310        320        330        340        350        360
ALEQHPYEHC EPSTMPGDLG LGLRMVRGVV HVYTRREPDE HCSEVELPYP DLQEFVADVN
       370        380        390        400        410        420
VLMALIINGP IKSFCYRRLQ YLSSKFQMHV LLNEMKELAA QKKVPHRDFY NIRKVDTHIH
       430        440        450        460        470        480
ASSCMNQKHL LRFIKRAMKR HLEEIVHVEQ GREQTLREVF ESMNLTAYDL SVDTLDVHAD
       490        500        510        520        530        540
RNTFHRFDKF NAKYNPIGES VLREIFIKTD NRVSGKYFAH IIKEVMSDLE ESKYQNAELR
       550        560        570        580        590        600
LSIYGRSRDE WDKLARWAVM HRVHSPNVRW LVQVPRLFDV YRTKGQLANF QEMLENIFLP
       610        620        630        640        650        660
LFEATVHPAS HPELHLFLEH VDGFDSVDDE SKPENHVFNL ESPLPEAWVE EDNPPYAYYL
       670        680        690        700        710        720
YYTFANMAML NHLRRQRGFH TFVLRPHCGE AGPIHHLVSA FMLAENISHG LLLRKAPVLQ
       730        740        750        760        770        780
YLYYLAQIGI AMSPLSNNSL FLSYHRNPLP EYLSRGLMVS LSTDDPLQFH FTKEPLMEEY
       790        800        810        820        830        840
SIATQVWKLS SCDMCELARN SVLMSGFSHK VKSHWLGPNY TKEGPEGNDI RRTNVPDIRV
       850        860        870
GYRYETLCQE LALITQAVQS EMLETIPEEA GITMSPGPQ         10         20         30         40         50         60
MRNRGQGLFR LRSRCFLHQS LPLGAGRRKG LDVAEPGPSR CRSDSPAVAA VVPAMASYPS
        70         80         90        100        110        120
GSGKPKAKYP FKKRASLQAS TAAPEARGGL GAPPLQSARS LPGPAPCLKH FPLDLRTSMD
       130        140        150        160        170        180
GKCKEIAEEL FTRSLAESEL RSAPYEFPEE SPIEQLEERR QRLERQISQD VKLEPDILLR
       190        200        210        220        230        240
AKQDFLKTDS DSDLQLYKEQ GEGQGDRSLR ERDVLEREFQ RVTISGEEKC GVPFTDLLDA
       250        260        270        280        290        300
AKSVVRALFI REKYMALSLQ SFCPTTRRYL QQLAEKPLET RTYEQGPDTP VSADAPVHPP
       310        320        330        340        350        360
ALEQHPYEHC EPSTMPGDLG LGLRMVRGVV HVYTRREPDE HCSEVELPYP DLQEFVADVN
       370        380        390        400        410        420
VLMALIINGP IKSFCYRRLQ YLSSKFQMHV LLNEMKELAA QKKVPHRDFY NIRKVDTHIH
       430        440        450        460        470        480
ASSCMNQKHL LRFIKRAMKR HLEEIVHVEQ GREQTLREVF ESMNLTAYDL SVDTLDVHAD
       490        500        510        520        530        540
RNTFHRFDKF NAKYNPIGES VLREIFIKTD NRVSGKYFAH IIKEVMSDLE ESKYQNAELR
       550        560        570        580        590        600
LSIYGRSRDE WDKLARWAVM HRVHSPNVRW LVQVPRLFDV YRTKGQLANF QEMLENIFLP
       610        620        630        640        650        660
LFEATVHPAS HPELHLFLEH VDGFDSVDDE SKPENHVFNL ESPLPEAWVE EDNPPYAYYL
       670        680        690        700        710        720
YYTFANMAML NHLRRQRGFH TFVLRPHCGE AGPIHHLVSA FMLAENISHG LLLRKAPVLQ
       730        740        750        760        770        780
YLYYLAQIGI AMSPLSNNSL FLSYHRNPLP EYLSRGLMVS LSTDDPLQFH FTKEPLMEEY
       790        800        810        820        830        840
SIATQVWKLS SCDMCELARN SVLMSGFSHK VKSHWLGPNY TKEGPEGNDI RRTNVPDIRV
       850        860        870
GYRYETLCQE LALITQAVQS EMLETIPEEA GITMSPGPQ         10         20         30         40         50         60
MRNRGQGLFR LRSRCFLHQS LPLGAGRRKG LDVAEPGPSR CRSDSPAVAA VVPAMASYPS
        70         80         90        100        110        120
GSGKPKAKYP FKKRASLQAS TAAPEARGGL GAPPLQSARS LPGPAPCLKH FPLDLRTSMD
       130        140        150        160        170        180
GKCKEIAEEL FTRSLAESEL RSAPYEFPEE SPIEQLEERR QRLERQISQD VKLEPDILLR
       190        200        210        220        230        240
AKQDFLKTDS DSDLQLYKEQ GEGQGDRSLR ERDVLEREFQ RVTISGEEKC GVPFTDLLDA
       250        260        270        280        290        300
AKSVVRALFI REKYMALSLQ SFCPTTRRYL QQLAEKPLET RTYEQGPDTP VSADAPVHPP
       310        320        330        340        350        360
ALEQHPYEHC EPSTMPGDLG LGLRMVRGVV HVYTRREPDE HCSEVELPYP DLQEFVADVN
       370        380        390        400        410        420
VLMALIINGP IKSFCYRRLQ YLSSKFQMHV LLNEMKELAA QKKVPHRDFY NIRKVDTHIH
       430        440        450        460        470        480
ASSCMNQKHL LRFIKRAMKR HLEEIVHVEQ GREQTLREVF ESMNLTAYDL SVDTLDVHAD
       490        500        510        520        530        540
RNTFHRFDKF NAKYNPIGES VLREIFIKTD NRVSGKYFAH IIKEVMSDLE ESKYQNAELR
       550        560        570        580        590        600
LSIYGRSRDE WDKLARWAVM HRVHSPNVRW LVQVPRLFDV YRTKGQLANF QEMLENIFLP
       610        620        630        640        650        660
LFEATVHPAS HPELHLFLEH VDGFDSVDDE SKPENHVFNL ESPLPEAWVE EDNPPYAYYL
       670        680        690        700        710        720
YYTFANMAML NHLRRQRGFH TFVLRPHCGE AGPIHHLVSA FMLAENISHG LLLRKAPVLQ
       730        740        750        760        770        780
YLYYLAQIGI AMSPLSNNSL FLSYHRNPLP EYLSRGLMVS LSTDDPLQFH FTKEPLMEEY
       790        800        810        820        830        840
SIATQVWKLS SCDMCELARN SVLMSGFSHK VKSHWLGPNY TKEGPEGNDI RRTNVPDIRV
       850        860        870
GYRYETLCQE LALITQAVQS EMLETIPEEA GITMSPGPQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01433-1-unknown	MRNRGQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01433-119-unknown	MDGKCK...	119	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66816
Q01433-119-unknown	MDGKCK...	119	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95740
Q01433-142-	SAPYEF...	142		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q01433-142-	SAPYEF...	142		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01433-142-	SAPYEF...	142		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q01433-142-	SAPYEF...	142		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q01433-142-	SAPYEF...	142		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q01433-142-	SAPYEF...	142		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q01433-142-unknown	SAPYEF...	142	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167025
Q01433-142-unknown	SAPYEF...	142	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167023
Q01433-142-unknown	SAPYEF...	142	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167026
Q01433-142-unknown	SAPYEF...	142	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167024
Q01433-171-unknown	VKLEPD...	171	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11869
Q01433-171-unknown	VKLEPD...	171	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139336
Q01433-171-unknown	VKLEPD...	171	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139379
Q01433-171-unknown	VKLEPD...	171	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141815
Q01433-171-unknown	VKLEPD...	171	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142171

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QISQDV	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11869
...QISQDV	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122411
...QISQDV	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122460
...QISQDV	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124996
...QISQDV	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125358
...SPGPQ	879	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SPGPQ	879	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62432
...SPGPQ	879	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62434
...SPGPQ	879	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62431
...SPGPQ	879	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62433

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	170	SQDV.\|.VKLE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)