Q01780: Exosome component 10 {ECO:0000305}

General Information

Protein names	- Exosome component 10 {ECO:0000305} - 3.1.13.- - Autoantigen PM/Scl 2 - P100 polymyositis-scleroderma overlap syndrome-associated autoantigen - Polymyositis/scleroderma autoantigen 100 kDa - PM/Scl-100 - Polymyositis/scleroderma autoantigen 2
Gene names	EXOSC10
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01780

5 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY
        70         80         90        100        110        120
DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR SKVTELEDKF DLLVDANDVI
       130        140        150        160        170        180
LERVGILLDE ASGVNKNQQP VLPAGLQVPK TVVSSWNRKA AEYGKKAKSE TFRLLHAKNI
       190        200        210        220        230        240
IRPQLKFREK IDNSNTPFLP KIFIKPNAQK PLPQALSKER RERPQDRPED LDVPPALADF
       250        260        270        280        290        300
IHQQRTQQVE QDMFAHPYQY ELNHFTPADA VLQKPQPQLY RPIEETPCHF ISSLDELVEL
       310        320        330        340        350        360
NEKLLNCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFII DTLELRSDMY ILNESLTDPA
       370        380        390        400        410        420
IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLGR HSLDHLLKLY CNVDSNKQYQ
       430        440        450        460        470        480
LADWRIRPLP EEMLSYARDD THYLLYIYDK MRLEMWERGN GQPVQLQVVW QRSRDICLKK
       490        500        510        520        530        540
FIKPIFTDES YLELYRKQKK HLNTQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI
       550        560        570        580        590        600
AEELPKEPQG IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSEVAAGV KKSGPLPSAE
       610        620        630        640        650        660
RLENVLFGPH DCSHAPPDGY PIIPTSGSVP VQKQASLFPD EKEDNLLGTT CLIATAVITL
       670        680        690        700        710        720
FNEPSAEDSK KGPLTVAQKK AQNIMESFEN PFRMFLPSLG HRAPVSQAAK FDPSTKIYEI
       730        740        750        760        770        780
SNRWKLAQVQ VQKDSKEAVK KKAAEQTAAR EQAKEACKAA AEQAISVRQQ VVLENAAKKR
       790        800        810        820        830        840
ERATSDPRTT EQKQEKKRLK ISKKPKDPEP PEKEFTPYDY SQSDFKAFAG NSKSKVSSQF
       850        860        870        880
DPNKQTPSGK KCIAAKKIKQ SVGNKSMSFP TGKSDRGFRY NWPQR

Isoforms

- Isoform 2 of Exosome component 10

Sequence View

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Directness:

Physiological Relevance:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q01780-1-unknown	MAPPST...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q01780-1-unknown	MAPPST...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74332
Q01780-253-unknown	MFAHPY...	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11875
Q01780-253-unknown	MFAHPY...	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148530
Q01780-735-unknown	SKEAVK...	735	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11877
Q01780-735-unknown	SKEAVK...	735	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155946
Q01780-758-unknown	KAAAEQ...	758	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14352
Q01780-758-unknown	KAAAEQ...	758	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156147
Q01780-789-unknown	TTEQKQ...	789	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10187
Q01780-789-unknown	TTEQKQ...	789	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156334

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVEQDM	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11875
...QVEQDM	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131904
...QVQKDS	734	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11877
...AKEACK	757	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14352
...AKEACK	757	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139613
...TSDPRT	788	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10187
...TSDPRT	788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139807
...NWPQR	885	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NWPQR	885	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69950

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	252	EQDM.\|.MFAH	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,
GRAB_HUMAN	734	QKDS.\|.SKEA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	757	EACK.\|.KAAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	788	DPRT.\|.TTEQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)