Q03164: Histone-lysine N-methyltransferase 2A

General Information

Protein names	- Histone-lysine N-methyltransferase 2A - Lysine N-methyltransferase 2A - 2.1.1.43 {ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:26886794} - ALL-1 {ECO:0000303\|PubMed:12453419} - CXXC-type zinc finger protein 7 - Myeloid/lymphoid or mixed-lineage leukemia - Myeloid/lymphoid or mixed-lineage leukemia protein 1 - Trithorax-like protein - Zinc finger protein HRX - MLL cleavage product N320 - N-terminal cleavage product of 320 kDa - p320 - MLL cleavage product C180 - C-terminal cleavage product of 180 kDa - p180
Gene names	KMT2A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q03164

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG PGAPPSPPAV
        70         80         90        100        110        120
AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS SGPALLRVGP GFDAALQVSA
       130        140        150        160        170        180
AIGTNLRRFR AVFGESGGGG GSGEDEQFLG FGSDEEVRVR SPTRSPSVKT SPRKPRGRPR
       190        200        210        220        230        240
SGSDRNSAIL SDPSVFSPLN KSETKSGDKI KKKDSKSIEK KRGRPPTFPG VKIKITHGKD
       250        260        270        280        290        300
ISELPKGNKE DSLKKIKRTP SATFQQATKI KKLRAGKLSP LKSKFKTGKL QIGRKGVQIV
       310        320        330        340        350        360
RRRGRPPSTE RIKTPSGLLI NSELEKPQKV RKDKEGTPPL TKEDKTVVRQ SPRRIKPVRI
       370        380        390        400        410        420
IPSSKRTDAT IAKQLLQRAK KGAQKKIEKE AAQLQGRKVK TQVKNIRQFI MPVVSAISSR
       430        440        450        460        470        480
IIKTPRRFIE DEDYDPPIKI ARLESTPNSR FSAPSCGSSE KSSAASQHSS QMSSDSSRSS
       490        500        510        520        530        540
SPSVDTSTDS QASEEIQVLP EERSDTPEVH PPLPISQSPE NESNDRRSRR YSVSERSFGS
       550        560        570        580        590        600
RTTKKLSTLQ SAPQQQTSSS PPPPLLTPPP PLQPASSISD HTPWLMPPTI PLASPFLPAS
       610        620        630        640        650        660
TAPMQGKRKS ILREPTFRWT SLKHSRSEPQ YFSSAKYAKE GLIRKPIFDN FRPPPLTPED
       670        680        690        700        710        720
VGFASGFSAS GTAASARLFS PLHSGTRFDM HKRSPLLRAP RFTPSEAHSR IFESVTLPSN
       730        740        750        760        770        780
RTSAGTSSSG VSNRKRKRKV FSPIRSEPRS PSHSMRTRSG RLSSSELSPL TPPSSVSSSL
       790        800        810        820        830        840
SISVSPLATS ALNPTFTFPS HSLTQSGESA EKNQRPRKQT SAPAEPFSSS SPTPLFPWFT
       850        860        870        880        890        900
PGSQTERGRN KDKAPEELSK DRDADKSVEK DKSRERDRER EKENKRESRK EKRKKGSEIQ
       910        920        930        940        950        960
SSSALYPVGR VSKEKVVGED VATSSSAKKA TGRKKSSSHD SGTDITSVTL GDTTAVKTKI
       970        980        990       1000       1010       1020
LIKKGRGNLE KTNLDLGPTA PSLEKEKTLC LSTPSSSTVK HSTSSIGSML AQADKLPMTD
      1030       1040       1050       1060       1070       1080
KRVASLLKKA KAQLCKIEKS KSLKQTDQPK AQGQESDSSE TSVRGPRIKH VCRRAAVALG
      1090       1100       1110       1120       1130       1140
RKRAVFPDDM PTLSALPWEE REKILSSMGN DDKSSIAGSE DAEPLAPPIK PIKPVTRNKA
      1150       1160       1170       1180       1190       1200
PQEPPVKKGR RSRRCGQCPG CQVPEDCGVC TNCLDKPKFG GRNIKKQCCK MRKCQNLQWM
      1210       1220       1230       1240       1250       1260
PSKAYLQKQA KAVKKKEKKS KTSEKKDSKE SSVVKNVVDS SQKPTPSARE DPAPKKSSSE
      1270       1280       1290       1300       1310       1320
PPPRKPVEEK SEEGNVSAPG PESKQATTPA SRKSSKQVSQ PALVIPPQPP TTGPPRKEVP
      1330       1340       1350       1360       1370       1380
KTTPSEPKKK QPPPPESGPE QSKQKKVAPR PSIPVKQKPK EKEKPPPVNK QENAGTLNIL
      1390       1400       1410       1420       1430       1440
STLSNGNSSK QKIPADGVHR IRVDFKEDCE AENVWEMGGL GILTSVPITP RVVCFLCASS
      1450       1460       1470       1480       1490       1500
GHVEFVYCQV CCEPFHKFCL EENERPLEDQ LENWCCRRCK FCHVCGRQHQ ATKQLLECNK
      1510       1520       1530       1540       1550       1560
CRNSYHPECL GPNYPTKPTK KKKVWICTKC VRCKSCGSTT PGKGWDAQWS HDFSLCHDCA
      1570       1580       1590       1600       1610       1620
KLFAKGNFCP LCDKCYDDDD YESKMMQCGK CDRWVHSKCE NLSDEMYEIL SNLPESVAYT
      1630       1640       1650       1660       1670       1680
CVNCTERHPA EWRLALEKEL QISLKQVLTA LLNSRTTSHL LRYRQAAKPP DLNPETEESI
      1690       1700       1710       1720       1730       1740
PSRSSPEGPD PPVLTEVSKQ DDQQPLDLEG VKRKMDQGNY TSVLEFSDDI VKIIQAAINS
      1750       1760       1770       1780       1790       1800
DGGQPEIKKA NSMVKSFFIR QMERVFPWFS VKKSRFWEPN KVSSNSGMLP NAVLPPSLDH
      1810       1820       1830       1840       1850       1860
NYAQWQEREE NSHTEQPPLM KKIIPAPKPK GPGEPDSPTP LHPPTPPILS TDRSREDSPE
      1870       1880       1890       1900       1910       1920
LNPPPGIEDN RQCALCLTYG DDSANDAGRL LYIGQNEWTH VNCALWSAEV FEDDDGSLKN
      1930       1940       1950       1960       1970       1980
VHMAVIRGKQ LRCEFCQKPG ATVGCCLTSC TSNYHFMCSR AKNCVFLDDK KVYCQRHRDL
      1990       2000       2010       2020       2030       2040
IKGEVVPENG FEVFRRVFVD FEGISLRRKF LNGLEPENIH MMIGSMTIDC LGILNDLSDC
      2050       2060       2070       2080       2090       2100
EDKLFPIGYQ CSRVYWSTTD ARKRCVYTCK IVECRPPVVE PDINSTVEHD ENRTIAHSPT
      2110       2120       2130       2140       2150       2160
SFTESSSKES QNTAEIISPP SPDRPPHSQT SGSCYYHVIS KVPRIRTPSY SPTQRSPGCR
      2170       2180       2190       2200       2210       2220
PLPSAGSPTP TTHEIVTVGD PLLSSGLRSI GSRRHSTSSL SPQRSKLRIM SPMRTGNTYS
      2230       2240       2250       2260       2270       2280
RNNVSSVSTT GTATDLESSA KVVDHVLGPL NSSTSLGQNT STSSNLQRTV VTVGNKNSHL
      2290       2300       2310       2320       2330       2340
DGSSSSEMKQ SSASDLVSKS SSLKGEKTKV LSSKSSEGSA HNVAYPGIPK LAPQVHNTTS
      2350       2360       2370       2380       2390       2400
RELNVSKIGS FAEPSSVSFS SKEALSFPHL HLRGQRNDRD QHTDSTQSAN SSPDEDTEVK
      2410       2420       2430       2440       2450       2460
TLKLSGMSNR SSIINEHMGS SSRDRRQKGK KSCKETFKEK HSSKSFLEPG QVTTGEEGNL
      2470       2480       2490       2500       2510       2520
KPEFMDEVLT PEYMGQRPCN NVSSDKIGDK GLSMPGVPKA PPMQVEGSAK ELQAPRKRTV
      2530       2540       2550       2560       2570       2580
KVTLTPLKME NESQSKNALK ESSPASPLQI ESTSPTEPIS ASENPGDGPV AQPSPNNTSC
      2590       2600       2610       2620       2630       2640
QDSQSNNYQN LPVQDRNLML PDGPKPQEDG SFKRRYPRRS ARARSNMFFG LTPLYGVRSY
      2650       2660       2670       2680       2690       2700
GEEDIPFYSS STGKKRGKRS AEGQVDGADD LSTSDEDDLY YYNFTRTVIS SGGEERLASH
      2710       2720       2730       2740       2750       2760
NLFREEEQCD LPKISQLDGV DDGTESDTSV TATTRKSSQI PKRNGKENGT ENLKIDRPED
      2770       2780       2790       2800       2810       2820
AGEKEHVTKS SVGHKNEPKM DNCHSVSRVK TQGQDSLEAQ LSSLESSRRV HTSTPSDKNL
      2830       2840       2850       2860       2870       2880
LDTYNTELLK SDSDNNNSDD CGNILPSDIM DFVLKNTPSM QALGESPESS SSELLNLGEG
      2890       2900       2910       2920       2930       2940
LGLDSNREKD MGLFEVFSQQ LPTTEPVDSS VSSSISAEEQ FELPLELPSD LSVLTTRSPT
      2950       2960       2970       2980       2990       3000
VPSQNPSRLA VISDSGEKRV TITEKSVASS ESDPALLSPG VDPTPEGHMT PDHFIQGHMD
      3010       3020       3030       3040       3050       3060
ADHISSPPCG SVEQGHGNNQ DLTRNSSTPG LQVPVSPTVP IQNQKYVPNS TDSPGPSQIS
      3070       3080       3090       3100       3110       3120
NAAVQTTPPH LKPATEKLIV VNQNMQPLYV LQTLPNGVTQ KIQLTSSVSS TPSVMETNTS
      3130       3140       3150       3160       3170       3180
VLGPMGGGLT LTTGLNPSLP TSQSLFPSAS KGLLPMSHHQ HLHSFPAATQ SSFPPNISNP
      3190       3200       3210       3220       3230       3240
PSGLLIGVQP PPDPQLLVSE SSQRTDLSTT VATPSSGLKK RPISRLQTRK NKKLAPSSTP
      3250       3260       3270       3280       3290       3300
SNIAPSDVVS NMTLINFTPS QLPNHPSLLD LGSLNTSSHR TVPNIIKRSK SSIMYFEPAP
      3310       3320       3330       3340       3350       3360
LLPQSVGGTA ATAAGTSTIS QDTSHLTSGS VSGLASSSSV LNVVSMQTTT TPTSSASVPG
      3370       3380       3390       3400       3410       3420
HVTLTNPRLL GTPDIGSISN LLIKASQQSL GIQDQPVALP PSSGMFPQLG TSQTPSTAAI
      3430       3440       3450       3460       3470       3480
TAASSICVLP STQTTGITAA SPSGEADEHY QLQHVNQLLA SKTGIHSSQR DLDSASGPQV
      3490       3500       3510       3520       3530       3540
SNFTQTVDAP NSMGLEQNKA LSSAVQASPT SPGGSPSSPS SGQRSASPSV PGPTKPKPKT
      3550       3560       3570       3580       3590       3600
KRFQLPLDKG NGKKHKVSHL RTSSSEAHIP DQETTSLTSG TGTPGAEAEQ QDTASVEQSS
      3610       3620       3630       3640       3650       3660
QKECGQPAGQ VAVLPEVQVT QNPANEQESA EPKTVEEEES NFSSPLMLWL QQEQKRKESI
      3670       3680       3690       3700       3710       3720
TEKKPKKGLV FEISSDDGFQ ICAESIEDAW KSLTDKVQEA RSNARLKQLS FAGVNGLRML
      3730       3740       3750       3760       3770       3780
GILHDAVVFL IEQLSGAKHC RNYKFRFHKP EEANEPPLNP HGSARAEVHL RKSAFDMFNF
      3790       3800       3810       3820       3830       3840
LASKHRQPPE YNPNDEEEEE VQLKSARRAT SMDLPMPMRF RHLKKTSKEA VGVYRSPIHG
      3850       3860       3870       3880       3890       3900
RGLFCKRNID AGEMVIEYAG NVIRSIQTDK REKYYDSKGI GCYMFRIDDS EVVDATMHGN
      3910       3920       3930       3940       3950       3960
AARFINHSCE PNCYSRVINI DGQKHIVIFA MRKIYRGEEL TYDYKFPIED ASNKLPCNCG

AKKCRKFLN

Isoforms

- Isoform 2 of Histone-lysine N-methyltransferase 2A - Isoform 3 of Histone-lysine N-methyltransferase 2A

Sequence View

        10         20         30         40         50         60
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG PGAPPSPPAV
        70         80         90        100        110        120
AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS SGPALLRVGP GFDAALQVSA
       130        140        150        160        170        180
AIGTNLRRFR AVFGESGGGG GSGEDEQFLG FGSDEEVRVR SPTRSPSVKT SPRKPRGRPR
       190        200        210        220        230        240
SGSDRNSAIL SDPSVFSPLN KSETKSGDKI KKKDSKSIEK KRGRPPTFPG VKIKITHGKD
       250        260        270        280        290        300
ISELPKGNKE DSLKKIKRTP SATFQQATKI KKLRAGKLSP LKSKFKTGKL QIGRKGVQIV
       310        320        330        340        350        360
RRRGRPPSTE RIKTPSGLLI NSELEKPQKV RKDKEGTPPL TKEDKTVVRQ SPRRIKPVRI
       370        380        390        400        410        420
IPSSKRTDAT IAKQLLQRAK KGAQKKIEKE AAQLQGRKVK TQVKNIRQFI MPVVSAISSR
       430        440        450        460        470        480
IIKTPRRFIE DEDYDPPIKI ARLESTPNSR FSAPSCGSSE KSSAASQHSS QMSSDSSRSS
       490        500        510        520        530        540
SPSVDTSTDS QASEEIQVLP EERSDTPEVH PPLPISQSPE NESNDRRSRR YSVSERSFGS
       550        560        570        580        590        600
RTTKKLSTLQ SAPQQQTSSS PPPPLLTPPP PLQPASSISD HTPWLMPPTI PLASPFLPAS
       610        620        630        640        650        660
TAPMQGKRKS ILREPTFRWT SLKHSRSEPQ YFSSAKYAKE GLIRKPIFDN FRPPPLTPED
       670        680        690        700        710        720
VGFASGFSAS GTAASARLFS PLHSGTRFDM HKRSPLLRAP RFTPSEAHSR IFESVTLPSN
       730        740        750        760        770        780
RTSAGTSSSG VSNRKRKRKV FSPIRSEPRS PSHSMRTRSG RLSSSELSPL TPPSSVSSSL
       790        800        810        820        830        840
SISVSPLATS ALNPTFTFPS HSLTQSGESA EKNQRPRKQT SAPAEPFSSS SPTPLFPWFT
       850        860        870        880        890        900
PGSQTERGRN KDKAPEELSK DRDADKSVEK DKSRERDRER EKENKRESRK EKRKKGSEIQ
       910        920        930        940        950        960
SSSALYPVGR VSKEKVVGED VATSSSAKKA TGRKKSSSHD SGTDITSVTL GDTTAVKTKI
       970        980        990       1000       1010       1020
LIKKGRGNLE KTNLDLGPTA PSLEKEKTLC LSTPSSSTVK HSTSSIGSML AQADKLPMTD
      1030       1040       1050       1060       1070       1080
KRVASLLKKA KAQLCKIEKS KSLKQTDQPK AQGQESDSSE TSVRGPRIKH VCRRAAVALG
      1090       1100       1110       1120       1130       1140
RKRAVFPDDM PTLSALPWEE REKILSSMGN DDKSSIAGSE DAEPLAPPIK PIKPVTRNKA
      1150       1160       1170       1180       1190       1200
PQEPPVKKGR RSRRCGQCPG CQVPEDCGVC TNCLDKPKFG GRNIKKQCCK MRKCQNLQWM
      1210       1220       1230       1240       1250       1260
PSKAYLQKQA KAVKKKEKKS KTSEKKDSKE SSVVKNVVDS SQKPTPSARE DPAPKKSSSE
      1270       1280       1290       1300       1310       1320
PPPRKPVEEK SEEGNVSAPG PESKQATTPA SRKSSKQVSQ PALVIPPQPP TTGPPRKEVP
      1330       1340       1350       1360       1370       1380
KTTPSEPKKK QPPPPESGPE QSKQKKVAPR PSIPVKQKPK EKEKPPPVNK QENAGTLNIL
      1390       1400       1410       1420       1430       1440
STLSNGNSSK QKIPADGVHR IRVDFKEDCE AENVWEMGGL GILTSVPITP RVVCFLCASS
      1450       1460       1470       1480       1490       1500
GHVEFVYCQV CCEPFHKFCL EENERPLEDQ LENWCCRRCK FCHVCGRQHQ ATKQLLECNK
      1510       1520       1530       1540       1550       1560
CRNSYHPECL GPNYPTKPTK KKKVWICTKC VRCKSCGSTT PGKGWDAQWS HDFSLCHDCA
      1570       1580       1590       1600       1610       1620
KLFAKGNFCP LCDKCYDDDD YESKMMQCGK CDRWVHSKCE NLSDEMYEIL SNLPESVAYT
      1630       1640       1650       1660       1670       1680
CVNCTERHPA EWRLALEKEL QISLKQVLTA LLNSRTTSHL LRYRQAAKPP DLNPETEESI
      1690       1700       1710       1720       1730       1740
PSRSSPEGPD PPVLTEVSKQ DDQQPLDLEG VKRKMDQGNY TSVLEFSDDI VKIIQAAINS
      1750       1760       1770       1780       1790       1800
DGGQPEIKKA NSMVKSFFIR QMERVFPWFS VKKSRFWEPN KVSSNSGMLP NAVLPPSLDH
      1810       1820       1830       1840       1850       1860
NYAQWQEREE NSHTEQPPLM KKIIPAPKPK GPGEPDSPTP LHPPTPPILS TDRSREDSPE
      1870       1880       1890       1900       1910       1920
LNPPPGIEDN RQCALCLTYG DDSANDAGRL LYIGQNEWTH VNCALWSAEV FEDDDGSLKN
      1930       1940       1950       1960       1970       1980
VHMAVIRGKQ LRCEFCQKPG ATVGCCLTSC TSNYHFMCSR AKNCVFLDDK KVYCQRHRDL
      1990       2000       2010       2020       2030       2040
IKGEVVPENG FEVFRRVFVD FEGISLRRKF LNGLEPENIH MMIGSMTIDC LGILNDLSDC
      2050       2060       2070       2080       2090       2100
EDKLFPIGYQ CSRVYWSTTD ARKRCVYTCK IVECRPPVVE PDINSTVEHD ENRTIAHSPT
      2110       2120       2130       2140       2150       2160
SFTESSSKES QNTAEIISPP SPDRPPHSQT SGSCYYHVIS KVPRIRTPSY SPTQRSPGCR
      2170       2180       2190       2200       2210       2220
PLPSAGSPTP TTHEIVTVGD PLLSSGLRSI GSRRHSTSSL SPQRSKLRIM SPMRTGNTYS
      2230       2240       2250       2260       2270       2280
RNNVSSVSTT GTATDLESSA KVVDHVLGPL NSSTSLGQNT STSSNLQRTV VTVGNKNSHL
      2290       2300       2310       2320       2330       2340
DGSSSSEMKQ SSASDLVSKS SSLKGEKTKV LSSKSSEGSA HNVAYPGIPK LAPQVHNTTS
      2350       2360       2370       2380       2390       2400
RELNVSKIGS FAEPSSVSFS SKEALSFPHL HLRGQRNDRD QHTDSTQSAN SSPDEDTEVK
      2410       2420       2430       2440       2450       2460
TLKLSGMSNR SSIINEHMGS SSRDRRQKGK KSCKETFKEK HSSKSFLEPG QVTTGEEGNL
      2470       2480       2490       2500       2510       2520
KPEFMDEVLT PEYMGQRPCN NVSSDKIGDK GLSMPGVPKA PPMQVEGSAK ELQAPRKRTV
      2530       2540       2550       2560       2570       2580
KVTLTPLKME NESQSKNALK ESSPASPLQI ESTSPTEPIS ASENPGDGPV AQPSPNNTSC
      2590       2600       2610       2620       2630       2640
QDSQSNNYQN LPVQDRNLML PDGPKPQEDG SFKRRYPRRS ARARSNMFFG LTPLYGVRSY
      2650       2660       2670       2680       2690       2700
GEEDIPFYSS STGKKRGKRS AEGQVDGADD LSTSDEDDLY YYNFTRTVIS SGGEERLASH
      2710       2720       2730       2740       2750       2760
NLFREEEQCD LPKISQLDGV DDGTESDTSV TATTRKSSQI PKRNGKENGT ENLKIDRPED
      2770       2780       2790       2800       2810       2820
AGEKEHVTKS SVGHKNEPKM DNCHSVSRVK TQGQDSLEAQ LSSLESSRRV HTSTPSDKNL
      2830       2840       2850       2860       2870       2880
LDTYNTELLK SDSDNNNSDD CGNILPSDIM DFVLKNTPSM QALGESPESS SSELLNLGEG
      2890       2900       2910       2920       2930       2940
LGLDSNREKD MGLFEVFSQQ LPTTEPVDSS VSSSISAEEQ FELPLELPSD LSVLTTRSPT
      2950       2960       2970       2980       2990       3000
VPSQNPSRLA VISDSGEKRV TITEKSVASS ESDPALLSPG VDPTPEGHMT PDHFIQGHMD
      3010       3020       3030       3040       3050       3060
ADHISSPPCG SVEQGHGNNQ DLTRNSSTPG LQVPVSPTVP IQNQKYVPNS TDSPGPSQIS
      3070       3080       3090       3100       3110       3120
NAAVQTTPPH LKPATEKLIV VNQNMQPLYV LQTLPNGVTQ KIQLTSSVSS TPSVMETNTS
      3130       3140       3150       3160       3170       3180
VLGPMGGGLT LTTGLNPSLP TSQSLFPSAS KGLLPMSHHQ HLHSFPAATQ SSFPPNISNP
      3190       3200       3210       3220       3230       3240
PSGLLIGVQP PPDPQLLVSE SSQRTDLSTT VATPSSGLKK RPISRLQTRK NKKLAPSSTP
      3250       3260       3270       3280       3290       3300
SNIAPSDVVS NMTLINFTPS QLPNHPSLLD LGSLNTSSHR TVPNIIKRSK SSIMYFEPAP
      3310       3320       3330       3340       3350       3360
LLPQSVGGTA ATAAGTSTIS QDTSHLTSGS VSGLASSSSV LNVVSMQTTT TPTSSASVPG
      3370       3380       3390       3400       3410       3420
HVTLTNPRLL GTPDIGSISN LLIKASQQSL GIQDQPVALP PSSGMFPQLG TSQTPSTAAI
      3430       3440       3450       3460       3470       3480
TAASSICVLP STQTTGITAA SPSGEADEHY QLQHVNQLLA SKTGIHSSQR DLDSASGPQV
      3490       3500       3510       3520       3530       3540
SNFTQTVDAP NSMGLEQNKA LSSAVQASPT SPGGSPSSPS SGQRSASPSV PGPTKPKPKT
      3550       3560       3570       3580       3590       3600
KRFQLPLDKG NGKKHKVSHL RTSSSEAHIP DQETTSLTSG TGTPGAEAEQ QDTASVEQSS
      3610       3620       3630       3640       3650       3660
QKECGQPAGQ VAVLPEVQVT QNPANEQESA EPKTVEEEES NFSSPLMLWL QQEQKRKESI
      3670       3680       3690       3700       3710       3720
TEKKPKKGLV FEISSDDGFQ ICAESIEDAW KSLTDKVQEA RSNARLKQLS FAGVNGLRML
      3730       3740       3750       3760       3770       3780
GILHDAVVFL IEQLSGAKHC RNYKFRFHKP EEANEPPLNP HGSARAEVHL RKSAFDMFNF
      3790       3800       3810       3820       3830       3840
LASKHRQPPE YNPNDEEEEE VQLKSARRAT SMDLPMPMRF RHLKKTSKEA VGVYRSPIHG
      3850       3860       3870       3880       3890       3900
RGLFCKRNID AGEMVIEYAG NVIRSIQTDK REKYYDSKGI GCYMFRIDDS EVVDATMHGN
      3910       3920       3930       3940       3950       3960
AARFINHSCE PNCYSRVINI DGQKHIVIFA MRKIYRGEEL TYDYKFPIED ASNKLPCNCG

AKKCRKFLN         10         20         30         40         50         60
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG PGAPPSPPAV
        70         80         90        100        110        120
AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS SGPALLRVGP GFDAALQVSA
       130        140        150        160        170        180
AIGTNLRRFR AVFGESGGGG GSGEDEQFLG FGSDEEVRVR SPTRSPSVKT SPRKPRGRPR
       190        200        210        220        230        240
SGSDRNSAIL SDPSVFSPLN KSETKSGDKI KKKDSKSIEK KRGRPPTFPG VKIKITHGKD
       250        260        270        280        290        300
ISELPKGNKE DSLKKIKRTP SATFQQATKI KKLRAGKLSP LKSKFKTGKL QIGRKGVQIV
       310        320        330        340        350        360
RRRGRPPSTE RIKTPSGLLI NSELEKPQKV RKDKEGTPPL TKEDKTVVRQ SPRRIKPVRI
       370        380        390        400        410        420
IPSSKRTDAT IAKQLLQRAK KGAQKKIEKE AAQLQGRKVK TQVKNIRQFI MPVVSAISSR
       430        440        450        460        470        480
IIKTPRRFIE DEDYDPPIKI ARLESTPNSR FSAPSCGSSE KSSAASQHSS QMSSDSSRSS
       490        500        510        520        530        540
SPSVDTSTDS QASEEIQVLP EERSDTPEVH PPLPISQSPE NESNDRRSRR YSVSERSFGS
       550        560        570        580        590        600
RTTKKLSTLQ SAPQQQTSSS PPPPLLTPPP PLQPASSISD HTPWLMPPTI PLASPFLPAS
       610        620        630        640        650        660
TAPMQGKRKS ILREPTFRWT SLKHSRSEPQ YFSSAKYAKE GLIRKPIFDN FRPPPLTPED
       670        680        690        700        710        720
VGFASGFSAS GTAASARLFS PLHSGTRFDM HKRSPLLRAP RFTPSEAHSR IFESVTLPSN
       730        740        750        760        770        780
RTSAGTSSSG VSNRKRKRKV FSPIRSEPRS PSHSMRTRSG RLSSSELSPL TPPSSVSSSL
       790        800        810        820        830        840
SISVSPLATS ALNPTFTFPS HSLTQSGESA EKNQRPRKQT SAPAEPFSSS SPTPLFPWFT
       850        860        870        880        890        900
PGSQTERGRN KDKAPEELSK DRDADKSVEK DKSRERDRER EKENKRESRK EKRKKGSEIQ
       910        920        930        940        950        960
SSSALYPVGR VSKEKVVGED VATSSSAKKA TGRKKSSSHD SGTDITSVTL GDTTAVKTKI
       970        980        990       1000       1010       1020
LIKKGRGNLE KTNLDLGPTA PSLEKEKTLC LSTPSSSTVK HSTSSIGSML AQADKLPMTD
      1030       1040       1050       1060       1070       1080
KRVASLLKKA KAQLCKIEKS KSLKQTDQPK AQGQESDSSE TSVRGPRIKH VCRRAAVALG
      1090       1100       1110       1120       1130       1140
RKRAVFPDDM PTLSALPWEE REKILSSMGN DDKSSIAGSE DAEPLAPPIK PIKPVTRNKA
      1150       1160       1170       1180       1190       1200
PQEPPVKKGR RSRRCGQCPG CQVPEDCGVC TNCLDKPKFG GRNIKKQCCK MRKCQNLQWM
      1210       1220       1230       1240       1250       1260
PSKAYLQKQA KAVKKKEKKS KTSEKKDSKE SSVVKNVVDS SQKPTPSARE DPAPKKSSSE
      1270       1280       1290       1300       1310       1320
PPPRKPVEEK SEEGNVSAPG PESKQATTPA SRKSSKQVSQ PALVIPPQPP TTGPPRKEVP
      1330       1340       1350       1360       1370       1380
KTTPSEPKKK QPPPPESGPE QSKQKKVAPR PSIPVKQKPK EKEKPPPVNK QENAGTLNIL
      1390       1400       1410       1420       1430       1440
STLSNGNSSK QKIPADGVHR IRVDFKEDCE AENVWEMGGL GILTSVPITP RVVCFLCASS
      1450       1460       1470       1480       1490       1500
GHVEFVYCQV CCEPFHKFCL EENERPLEDQ LENWCCRRCK FCHVCGRQHQ ATKQLLECNK
      1510       1520       1530       1540       1550       1560
CRNSYHPECL GPNYPTKPTK KKKVWICTKC VRCKSCGSTT PGKGWDAQWS HDFSLCHDCA
      1570       1580       1590       1600       1610       1620
KLFAKGNFCP LCDKCYDDDD YESKMMQCGK CDRWVHSKCE NLSDEMYEIL SNLPESVAYT
      1630       1640       1650       1660       1670       1680
CVNCTERHPA EWRLALEKEL QISLKQVLTA LLNSRTTSHL LRYRQAAKPP DLNPETEESI
      1690       1700       1710       1720       1730       1740
PSRSSPEGPD PPVLTEVSKQ DDQQPLDLEG VKRKMDQGNY TSVLEFSDDI VKIIQAAINS
      1750       1760       1770       1780       1790       1800
DGGQPEIKKA NSMVKSFFIR QMERVFPWFS VKKSRFWEPN KVSSNSGMLP NAVLPPSLDH
      1810       1820       1830       1840       1850       1860
NYAQWQEREE NSHTEQPPLM KKIIPAPKPK GPGEPDSPTP LHPPTPPILS TDRSREDSPE
      1870       1880       1890       1900       1910       1920
LNPPPGIEDN RQCALCLTYG DDSANDAGRL LYIGQNEWTH VNCALWSAEV FEDDDGSLKN
      1930       1940       1950       1960       1970       1980
VHMAVIRGKQ LRCEFCQKPG ATVGCCLTSC TSNYHFMCSR AKNCVFLDDK KVYCQRHRDL
      1990       2000       2010       2020       2030       2040
IKGEVVPENG FEVFRRVFVD FEGISLRRKF LNGLEPENIH MMIGSMTIDC LGILNDLSDC
      2050       2060       2070       2080       2090       2100
EDKLFPIGYQ CSRVYWSTTD ARKRCVYTCK IVECRPPVVE PDINSTVEHD ENRTIAHSPT
      2110       2120       2130       2140       2150       2160
SFTESSSKES QNTAEIISPP SPDRPPHSQT SGSCYYHVIS KVPRIRTPSY SPTQRSPGCR
      2170       2180       2190       2200       2210       2220
PLPSAGSPTP TTHEIVTVGD PLLSSGLRSI GSRRHSTSSL SPQRSKLRIM SPMRTGNTYS
      2230       2240       2250       2260       2270       2280
RNNVSSVSTT GTATDLESSA KVVDHVLGPL NSSTSLGQNT STSSNLQRTV VTVGNKNSHL
      2290       2300       2310       2320       2330       2340
DGSSSSEMKQ SSASDLVSKS SSLKGEKTKV LSSKSSEGSA HNVAYPGIPK LAPQVHNTTS
      2350       2360       2370       2380       2390       2400
RELNVSKIGS FAEPSSVSFS SKEALSFPHL HLRGQRNDRD QHTDSTQSAN SSPDEDTEVK
      2410       2420       2430       2440       2450       2460
TLKLSGMSNR SSIINEHMGS SSRDRRQKGK KSCKETFKEK HSSKSFLEPG QVTTGEEGNL
      2470       2480       2490       2500       2510       2520
KPEFMDEVLT PEYMGQRPCN NVSSDKIGDK GLSMPGVPKA PPMQVEGSAK ELQAPRKRTV
      2530       2540       2550       2560       2570       2580
KVTLTPLKME NESQSKNALK ESSPASPLQI ESTSPTEPIS ASENPGDGPV AQPSPNNTSC
      2590       2600       2610       2620       2630       2640
QDSQSNNYQN LPVQDRNLML PDGPKPQEDG SFKRRYPRRS ARARSNMFFG LTPLYGVRSY
      2650       2660       2670       2680       2690       2700
GEEDIPFYSS STGKKRGKRS AEGQVDGADD LSTSDEDDLY YYNFTRTVIS SGGEERLASH
      2710       2720       2730       2740       2750       2760
NLFREEEQCD LPKISQLDGV DDGTESDTSV TATTRKSSQI PKRNGKENGT ENLKIDRPED
      2770       2780       2790       2800       2810       2820
AGEKEHVTKS SVGHKNEPKM DNCHSVSRVK TQGQDSLEAQ LSSLESSRRV HTSTPSDKNL
      2830       2840       2850       2860       2870       2880
LDTYNTELLK SDSDNNNSDD CGNILPSDIM DFVLKNTPSM QALGESPESS SSELLNLGEG
      2890       2900       2910       2920       2930       2940
LGLDSNREKD MGLFEVFSQQ LPTTEPVDSS VSSSISAEEQ FELPLELPSD LSVLTTRSPT
      2950       2960       2970       2980       2990       3000
VPSQNPSRLA VISDSGEKRV TITEKSVASS ESDPALLSPG VDPTPEGHMT PDHFIQGHMD
      3010       3020       3030       3040       3050       3060
ADHISSPPCG SVEQGHGNNQ DLTRNSSTPG LQVPVSPTVP IQNQKYVPNS TDSPGPSQIS
      3070       3080       3090       3100       3110       3120
NAAVQTTPPH LKPATEKLIV VNQNMQPLYV LQTLPNGVTQ KIQLTSSVSS TPSVMETNTS
      3130       3140       3150       3160       3170       3180
VLGPMGGGLT LTTGLNPSLP TSQSLFPSAS KGLLPMSHHQ HLHSFPAATQ SSFPPNISNP
      3190       3200       3210       3220       3230       3240
PSGLLIGVQP PPDPQLLVSE SSQRTDLSTT VATPSSGLKK RPISRLQTRK NKKLAPSSTP
      3250       3260       3270       3280       3290       3300
SNIAPSDVVS NMTLINFTPS QLPNHPSLLD LGSLNTSSHR TVPNIIKRSK SSIMYFEPAP
      3310       3320       3330       3340       3350       3360
LLPQSVGGTA ATAAGTSTIS QDTSHLTSGS VSGLASSSSV LNVVSMQTTT TPTSSASVPG
      3370       3380       3390       3400       3410       3420
HVTLTNPRLL GTPDIGSISN LLIKASQQSL GIQDQPVALP PSSGMFPQLG TSQTPSTAAI
      3430       3440       3450       3460       3470       3480
TAASSICVLP STQTTGITAA SPSGEADEHY QLQHVNQLLA SKTGIHSSQR DLDSASGPQV
      3490       3500       3510       3520       3530       3540
SNFTQTVDAP NSMGLEQNKA LSSAVQASPT SPGGSPSSPS SGQRSASPSV PGPTKPKPKT
      3550       3560       3570       3580       3590       3600
KRFQLPLDKG NGKKHKVSHL RTSSSEAHIP DQETTSLTSG TGTPGAEAEQ QDTASVEQSS
      3610       3620       3630       3640       3650       3660
QKECGQPAGQ VAVLPEVQVT QNPANEQESA EPKTVEEEES NFSSPLMLWL QQEQKRKESI
      3670       3680       3690       3700       3710       3720
TEKKPKKGLV FEISSDDGFQ ICAESIEDAW KSLTDKVQEA RSNARLKQLS FAGVNGLRML
      3730       3740       3750       3760       3770       3780
GILHDAVVFL IEQLSGAKHC RNYKFRFHKP EEANEPPLNP HGSARAEVHL RKSAFDMFNF
      3790       3800       3810       3820       3830       3840
LASKHRQPPE YNPNDEEEEE VQLKSARRAT SMDLPMPMRF RHLKKTSKEA VGVYRSPIHG
      3850       3860       3870       3880       3890       3900
RGLFCKRNID AGEMVIEYAG NVIRSIQTDK REKYYDSKGI GCYMFRIDDS EVVDATMHGN
      3910       3920       3930       3940       3950       3960
AARFINHSCE PNCYSRVINI DGQKHIVIFA MRKIYRGEEL TYDYKFPIED ASNKLPCNCG

AKKCRKFLN

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q03164-1-unknown	MAHSCR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q03164-1-unknown	MAHSCR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79177
Q03164-1-unknown	MAHSCR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79178
Q03164-2385-	STQSAN...	2385		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q03164-2385-	STQSAN...	2385		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q03164-2385-unknown	STQSAN...	2385	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165645
Q03164-2385-unknown	STQSAN...	2385	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165644
Q03164-2667-unknown	GADDLS...	2667	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31671
Q03164-2667-unknown	GADDLS...	2667	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159233
Q03164-2667-unknown	GADDLS...	2667	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159237
Q03164-2719-unknown	GVDDGT...	2719	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q03164-2719-unknown	GVDDGT...	2719	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31674
Q03164-2719-unknown	GVDDGT...	2719	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116524
Q03164-2719-unknown	GVDDGT...	2719	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116523
Q03164-2719-	GVDDGT...	2719		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q03164-3011-	SVEQGH...	3011		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q03164-3011-unknown	SVEQGH...	3011	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173481
Q03164-3011-unknown	SVEQGH...	3011	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173480

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EGQVDG	2666	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31671
...EGQVDG	2666	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt142737
...EGQVDG	2666	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt142741
...ISQLDG	2718	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ISQLDG	2718	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31674
...ISQLDG	2718	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93843
...ISQLDG	2718	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93842
...RKFLN	3969	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RKFLN	3969	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74795
...RKFLN	3969	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74796

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TASP1_HUMAN	2666	QVDG.\|.GADD	inferred from experiment	unknown	MEROPS	Stunnenberg HG	Zhou H et al.:Uncleaved TFIIA is a substrate ... (T02.004)	16537915,
TASP1_HUMAN	2718	QLDG.\|.GVDD	inferred from experiment	unknown	MEROPS	Korsmeyer SJ	Hsieh JJ et al.:Taspase1: a threonine aspartase... (T02.004)	14636557,

TopFIND

Q03164: Histone-lysine N-methyltransferase 2A

General Information

8

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates